INT102261

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.05
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (ANK1) cytoplasm (ANK1) cytosol (ANK1)
signal transduction (ANK1) structural molecule activity (ANK1) cytoskeleton (ANK1)
Anatomy Link Frequency
peripheral nerve 1
ANK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 12 100.00 Very High Very High Very High
Nav1.6 8 96.24 Very High Very High Very High
Pain 8 89.96 High High
Neuronal excitability 2 88.08 High High
TRP channel 4 82.48 Quite High
unmyelinated 1 63.60 Quite High
Inflammation 1 60.00 Quite High
Neuropeptide 2 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroma 7 90.08 High High
Disease 10 79.76 Quite High
Channelopathies 1 77.36 Quite High
Injury 1 75.00 Quite High
INFLAMMATION 1 60.00 Quite High
Targeted Disruption 2 35.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A double labeling technique with highly specific antibodies against peripheral nerve type 1 (Na(v)1.7), and peripheral nerve type 3 (Na(v)1.8) sodium channels and anti-ankyrin G antibodies detected sodium channels and ankyrin G on the same section, using confocal laser scanning microscopy.
Gene_expression (detected) of ankyrin in peripheral nerve associated with sodium channel
1) Confidence 0.63 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11950515 Disease Relevance 0.57 Pain Relevance 0.79
Expression of chimeras between the two isoforms of ankyrin suggests that the membrane-binding domain of ankyrin-G is critical for reducing the Ina-p of Nav1.6.
Gene_expression (Expression) of ankyrin associated with nav1.6
2) Confidence 0.15 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775201 Disease Relevance 0 Pain Relevance 0.47
On the other hand, Ina-p was barely detected on co-expression with ankyrin-G.
Gene_expression (expression) of ankyrin
3) Confidence 0.15 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775201 Disease Relevance 0 Pain Relevance 0.46
The mammalian TRP (transient receptor potential) family consists of six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) groups.
Gene_expression (groups) of ankyrin
4) Confidence 0.03 Published 2005 Journal Sci. STKE Section Abstract Doc Link 16077087 Disease Relevance 0.48 Pain Relevance 0.15

General Comments

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