INT102268

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 10.77
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 2
urinary bladder 1
blood 1
bladders 1
lung 1
H2-S (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 317 99.40 Very High Very High Very High
backache 1 90.64 High High
cytokine 95 90.40 High High
tetrodotoxin 3 88.68 High High
alcohol 3 86.04 High High
anesthesia 23 83.00 Quite High
potassium channel 3 76.24 Quite High
chemokine 10 74.96 Quite High
cva 5 53.36 Quite High
adenocard 3 48.80 Quite Low
Disease Link Frequency Relevance Heat
Lung Injury 290 99.96 Very High Very High Very High
Hypoxia 23 99.92 Very High Very High Very High
Toxicity 16 99.72 Very High Very High Very High
INFLAMMATION 299 99.40 Very High Very High Very High
Hypothermia 105 99.08 Very High Very High Very High
Endotoxemia 8 98.08 Very High Very High Very High
Chronic Fatigue Syndrome 450 97.84 Very High Very High Very High
Infection 97 91.04 High High
Low Back Pain 4 90.64 High High
Peripheral Arterial Disease 5 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cells do not produce H2S, deoxyribonuclease and lipase [73].
Neg (not) Gene_expression (produce) of H2S
1) Confidence 0.75 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2996186 Disease Relevance 0.24 Pain Relevance 0
Interestingly, it has recently been shown that H2S is also present in gut nerves in humans and guinea pigs.
Gene_expression (present) of H2S in gut
2) Confidence 0.75 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 0.64 Pain Relevance 0.06
People with CFS were shown to have higher concentrations of intestinal bacteria than normal, which probably leads to higher levels of H2S.
Gene_expression (levels) of H2S associated with chronic fatigue syndrome
3) Confidence 0.65 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 0.71 Pain Relevance 0.08
H2S is normally found in the body, which suggests that this molecule could have physiologic relevance.
Gene_expression (found) of H2S in body
4) Confidence 0.58 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2964729 Disease Relevance 0.57 Pain Relevance 0.15
Cells do not use citrate, do not produce H2S or lipase, and do not hydrolyze urea [73].
Neg (not) Gene_expression (produce) of H2S
5) Confidence 0.58 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2996186 Disease Relevance 0.33 Pain Relevance 0
Mean arterial pressure increased significantly (p = .007), whereas heart rate (p = .14), cardiac output (p = .89), and lactate (p = .67) did not change significantly during H2S exposures in H2S group; all the variables decreased significantly in the control group (p < .01 for all), and p < .01 by comparison with H2S group except for lactate (p = .05).
Gene_expression (exposures) of H2S in heart
6) Confidence 0.58 Published 2008 Journal Pediatr Crit Care Med Section Body Doc Link 18477923 Disease Relevance 0 Pain Relevance 0
Mean arterial pressure increased significantly (p = .007), whereas heart rate (p = .14), cardiac output (p = .89), and lactate (p = .67) did not change significantly during H2S exposures in H2S group; all the variables decreased significantly in the control group (p < .01 for all), and p < .01 by comparison with H2S group except for lactate (p = .05).
Gene_expression (exposures) of H2S in heart
7) Confidence 0.58 Published 2008 Journal Pediatr Crit Care Med Section Body Doc Link 18477923 Disease Relevance 0 Pain Relevance 0
Inhibitors of H2S synthesis also inhibited hypoxic relaxation.
Gene_expression (synthesis) of H2S associated with hypoxia
8) Confidence 0.27 Published 2006 Journal J. Exp. Biol. Section Abstract Doc Link 16888071 Disease Relevance 0.32 Pain Relevance 0.13
The predicted odor at 24 ppb in the present study, based on the linear regression function from Table 4 [odor = 1.25 + 0.17 × H2S (ppb)] produces a similar value of 5.33.
Gene_expression (produces) of H2S
9) Confidence 0.24 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2569096 Disease Relevance 0.09 Pain Relevance 0
Unlike the weather variables, H2S levels varied markedly within neighborhoods.
Gene_expression (levels) of H2S
10) Confidence 0.24 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2569096 Disease Relevance 0.06 Pain Relevance 0
In the present study we examined H2S production and its physiological effects in urinary bladder from steelhead and rainbow trout (Oncorhynchus mykiss) and evaluated the relationship between H2S and hypoxia.
Spec (examined) Gene_expression (production) of H2S in urinary bladder associated with hypoxia
11) Confidence 0.23 Published 2006 Journal J. Exp. Biol. Section Abstract Doc Link 16888071 Disease Relevance 0.26 Pain Relevance 0
H2S was produced by trout bladders, and its production was sensitive to inhibitors of cystathionine beta-synthase and cystathionine gamma-lyase.
Gene_expression (produced) of H2S in bladders
12) Confidence 0.23 Published 2006 Journal J. Exp. Biol. Section Abstract Doc Link 16888071 Disease Relevance 0.26 Pain Relevance 0.03
A mixed model with fixed effects for wind speed and random effects for H2S showed that H2S and odor were not associated at medium wind speed (?
Gene_expression (effects) of H2S
13) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2569096 Disease Relevance 0 Pain Relevance 0
We considered H2S levels for hours when all measurements were below the detection limit of 2 ppb to be zero.
Gene_expression (levels) of H2S
14) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2569096 Disease Relevance 0 Pain Relevance 0
Although odor was highest at high wind speeds, mean H2S levels were lowest at high wind speeds (0.05 ppb) compared with medium (0.09 ppb) and low (0.45 ppb) wind speeds.
Gene_expression (levels) of H2S
15) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2569096 Disease Relevance 0 Pain Relevance 0
However, endogenously produced H2S also mediated inflammation during experimental endotoxemia [23], suggesting a dual role of H2S in inflammation.
Gene_expression (produced) of H2S associated with endotoxemia and inflammation
16) Confidence 0.06 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2952106 Disease Relevance 1.65 Pain Relevance 0.42
The anti-inflammatory properties of H2S have also been shown after inhibition of endogenously produced H2S [22].
Gene_expression (produced) of H2S associated with inflammation
17) Confidence 0.05 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2952106 Disease Relevance 1.64 Pain Relevance 0.42
Reversibility of suspended animation induced by an H2S donor
Gene_expression (donor) of H2S
18) Confidence 0.05 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2952106 Disease Relevance 0.91 Pain Relevance 0.16
This accords with findings in a mice VILI model, in which H2S reduced lung injury, but mild hypothermia did not [21].
Gene_expression (reduced) of H2S in lung associated with lung injury and hypothermia
19) Confidence 0.05 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2952106 Disease Relevance 1.71 Pain Relevance 0.34
As suspended animation is accompanied by hypothermia, additional control groups were used, in which animals were actively cooled to reproduce the H2S-induced fall in temperature, by placing ice bags on the belly.


Gene_expression (reproduce) of H2S associated with hypothermia
20) Confidence 0.05 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2952106 Disease Relevance 0.48 Pain Relevance 0.03

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