INT102272

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 41
Total Number 45
Disease Relevance 30.89
Pain Relevance 11.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
T cells 4
Treg 3
macrophages 1
Th1 cells 1
eosinophils 1
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 928 100.00 Very High Very High Very High
Inflammation 760 100.00 Very High Very High Very High
adenocard 20 100.00 Very High Very High Very High
Endocannabinoid 96 99.98 Very High Very High Very High
rheumatoid arthritis 295 99.32 Very High Very High Very High
Cannabinoid 354 99.04 Very High Very High Very High
Fibrositis 102 98.70 Very High Very High Very High
complementary and alternative medicine 66 98.48 Very High Very High Very High
Inflammatory response 45 98.44 Very High Very High Very High
Crohn's disease 11 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 797 100.00 Very High Very High Very High
Hypersensitivity 128 100.00 Very High Very High Very High
Autoimmune Disease 124 100.00 Very High Very High Very High
Schistosomiasis 85 99.92 Very High Very High Very High
Papillomavirus Infection 91 99.80 Very High Very High Very High
Disease 495 99.76 Very High Very High Very High
Asthma 1158 99.68 Very High Very High Very High
Genetic Predisposition To Disease 13 99.68 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 222 99.48 Very High Very High Very High
Rheumatoid Arthritis 299 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects indicate that ABR-215062 may mediate its effects by regulation of Th1/Th2 cytokine balance and suggest that ABR-215062 is potentially a new chemical entity for effective treatment of autoimmune diseases.
Regulation (regulation) of Th1 associated with autoimmune disease and cytokine
1) Confidence 0.44 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11985832 Disease Relevance 1.08 Pain Relevance 0.85
Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells.
Regulation (regulate) of Th1 in endothelial cells associated with adenocard and cytokine
2) Confidence 0.44 Published 2003 Journal J. Immunol. Section Title Doc Link 14530318 Disease Relevance 0.09 Pain Relevance 0.57
FMS patients and family members without rare variants differed from control subjects with regard to both TH1 (IFN?)
Regulation (control) of TH1 associated with fibrositis
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.85 Pain Relevance 0.56
Crohn's disease and ulcerative colitis, the major forms of IBD in humans are associated with exaggerated and poorly controlled Th1 or Th2 responses, respectively, and with a more complex networks of cytokine interactions, involving Th17 [3].
Regulation (controlled) of Th1 associated with inflammatory bowel disease, crohn's disease, disease and cytokine
4) Confidence 0.29 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.76 Pain Relevance 0.42
It is therefore of interest that several recent studies have indicated that DMARDs appear to be able to modulate the Th1/Th2 balance.
Regulation (modulate) of Th1
5) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.67 Pain Relevance 0.32
Although IL-4 production by T cells from the peripheral blood of RA patients is increased compared with that of healthy controls, this Th2 activity seems to be insufficient to control Th1-associated inflammation in RA [11-13].
Regulation (control) of Th1-associated in blood associated with inflammation and rheumatoid arthritis
6) Confidence 0.26 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 1.19 Pain Relevance 0.59
PGs also suppress a TH1 response.
Regulation (response) of TH1
7) Confidence 0.26 Published 2002 Journal Viral Immunol. Section Abstract Doc Link 11952135 Disease Relevance 0.54 Pain Relevance 0.18
We now show that Pin1, a third member of the PPIase family mediates the post-transcriptional regulation of Th1 cytokines by activated T cells.
Regulation (regulation) of Th1 in T cells associated with cytokine
8) Confidence 0.26 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1790862 Disease Relevance 0 Pain Relevance 0.14
This finding likely has relevance for others using IFA adjuvants, as it reflects an unbalanced early Th2 dominance with the potential to compromise induction of Th1 and Tc1 responses.
Regulation (responses) of Th1
9) Confidence 0.23 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.23 Pain Relevance 0.03
The concept of modulating the Th1/Th2 balance as a treatment for chronic autoimmunity has been successfully applied in a number of animal models of autoimmune diseases [83,84].
Regulation (modulating) of Th1 associated with autoimmune disease
10) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.91 Pain Relevance 0.40
2 chain gene is located close to the 1p22.2 region [38], and plays an important role in the regulation of the Th1-type immune response.
Regulation (regulation) of Th1
11) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.55 Pain Relevance 0.12
As previous studies have shown that sterile immunity in schistosomiasis is dependent on IgE levels, eosinophils and on the Th1/Th2 balance, our laboratory decided to test whether any allelic variants in the IL4, IL5 and IL13 genes would predispose individuals to high infection levels by Schistosoma [61].
Regulation (dependent) of Th1 in eosinophils associated with infection and schistosomiasis
12) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.73 Pain Relevance 0
This genetic region encodes several cytokines that regulate the differentiation of Th1 and Th2 lymphocytes.
Regulation (regulate) of Th1 in lymphocytes associated with cytokine
13) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.36 Pain Relevance 0.05
TH1 responses are classically defined by the production of interferon (IFN)-?
Regulation (responses) of TH1
14) Confidence 0.15 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 0.66 Pain Relevance 0.04
Further studies are needed to unravel how the Th1 and Th2 balance may affect the pathology of the RSV-infected eye.
Spec (may) Regulation (affect) of Th1 in eye associated with respiratory syncytial virus
15) Confidence 0.13 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 1.10 Pain Relevance 0.42
Therefore, we aimed to determine whether a specific cytokine pattern in the aqueous humor would allow a conclusion on the immune cells (Th1 or Th2 cell) responsible for this respective cytokine expression, as discussed above for each cytokine.
Spec (whether) Regulation (responsible) of Th1 in Th2 cell associated with cytokine
16) Confidence 0.12 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2807615 Disease Relevance 0.06 Pain Relevance 0.33
The BD™ Cytometric Bead Array Human Th1/Th2 Cytokine kit (BD Biosciences, San Jose, CA, USA) was used to quantitatively measure the levels of IL-2, IL-4, IL-6, IL-10, TNF-?
Regulation (used) of Th1 associated with cytokine
17) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.24 Pain Relevance 0.13
a shift from a Th1-type to a Th2-type cytokine response was observed when healthy
Regulation (response) of Th1 associated with cytokine
18) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.73 Pain Relevance 0.43
TBX21 encodes T-bet, a T-box transcription factor expressed in T cells, which influences naive T lymphocyte development and has been implicated in asthma pathogenesis.31 The -1993T T > C SNP in the TBX21 promoter was found to be associated with an increased risk for AIA in a Japanese population by increasing transcriptional activity.32 This genetic variation can cause inappropriate Th1 responses in the airway, leading to severe airway inflammation in combination with antigen-specific Th2 responses.
Regulation (responses) of Th1 in T cells associated with asthma and inflammation
19) Confidence 0.11 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.01 Pain Relevance 0.05
Understanding of the role of the active vitamin D hormone (1,25-hydroxyvitamin D) in immunodysregulation via down-regulation of Th1 immunity is increasing [2].
Regulation (regulation) of Th1
20) Confidence 0.09 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2518945 Disease Relevance 0.57 Pain Relevance 0.25

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