INT102276

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.74
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
neurons 2
DRG 2
amacrine cells 1
ganglion 1
Grin2d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 13 100.00 Very High Very High Very High
nMDA receptor 59 99.78 Very High Very High Very High
Neuropathic pain 2 99.24 Very High Very High Very High
Calcitonin gene-related peptide 3 97.32 Very High Very High Very High
gABA 6 97.12 Very High Very High Very High
Lasting pain 3 97.08 Very High Very High Very High
Dopamine 2 96.44 Very High Very High Very High
Serotonin 2 96.04 Very High Very High Very High
antagonist 10 95.60 Very High Very High Very High
noradrenaline 2 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 68 99.28 Very High Very High Very High
Neuropathic Pain 3 99.24 Very High Very High Very High
Diabetic Retinopathy 16 97.84 Very High Very High Very High
Pain 11 97.08 Very High Very High Very High
Glaucoma 8 96.84 Very High Very High Very High
Retinal Diseases 12 96.36 Very High Very High Very High
Hypoxia 576 95.24 Very High Very High Very High
Dyspepsia 41 92.92 High High
INFLAMMATION 47 85.52 High High
Death 4 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time RT-PCR showed that NR2B and NR2D were expressed at higher levels than NR2A and NR2C in DRG.
Gene_expression (expressed) of NR2D in DRG
1) Confidence 0.71 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.09 Pain Relevance 0.25
Western blots indicated that rat dorsal root ganglia (DRG) contain NR1, NR2B, NR2C, and NR2D but not NR2A.
Gene_expression (contain) of NR2D in DRG
2) Confidence 0.62 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.09 Pain Relevance 0.25
The expression pattern of the individual NMDA-R subunits (NR1, NR2A, NR2B, NR2C, and NR2D) was further studied by quantitative real-time RT–PCR.
Gene_expression (expression) of NR2D
3) Confidence 0.61 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.41 Pain Relevance 0.12
Nevertheless these results may have important implications for the design of retinal neuroprotective agents because they suggest that NR2C and NR2D-containing NMDAR subtypes may be the best targets.
Gene_expression (subtypes) of NR2D-containing
4) Confidence 0.61 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.58 Pain Relevance 0.16
The NMDA receptor subtype mRNAs for NR1, NR2A-D, and NR3 are expressed in mouse retinal ganglion and amacrine cells [74].
Gene_expression (expressed) of NR2A-D in amacrine cells associated with ganglion cysts and nmda receptor
5) Confidence 0.54 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.20 Pain Relevance 0.12
The N-methyl-D-aspartate (NMDA) receptor subunits NR1 and NR2D and proteinase-activated receptor-2 (PAR2) were also found in these neurons.
Gene_expression (found) of NR2D in neurons
6) Confidence 0.48 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424003 Disease Relevance 0.07 Pain Relevance 0.31
In this regard, this study sought to characterize the localization and expression pattern for the NMDAR-2D subunit in a rat model of neuropathic pain.
Gene_expression (expression) of NMDAR-2D subunit associated with neuropathic pain
7) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18585442 Disease Relevance 0.27 Pain Relevance 0.63
It was found that the NR2 subunits of the NMDA receptor, NR2B and NR2D, are present on colonic neurons [37].
Gene_expression (present) of NR2D in neurons associated with nmda receptor
8) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.72 Pain Relevance 0.71
The NMDA receptor subtype mRNAs for NR1, NR2A-D, and NR3 are expressed in mouse retinal ganglion and amacrine cells [74].
Gene_expression (expressed) of NR2A-D in ganglion associated with ganglion cysts and nmda receptor
9) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.20 Pain Relevance 0.12
Unilateral labyrinthectomy induced changes in expression levels of receptors for glutamate (e.g., NR1 and NR2A-D subunits of the NMDA receptor [47] and GluR2-4 subunits of the AMPA receptor [48]) have been studied in the vestibular nuclei.
Gene_expression (expression) of NR2A-D associated with glutamate and nmda receptor
10) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC517932 Disease Relevance 0 Pain Relevance 0.69

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