INT102277

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
neurons 1
DRG 1
Grin2d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 19 99.32 Very High Very High Very High
Inflammation 45 98.68 Very High Very High Very High
Calcitonin gene-related peptide 2 97.32 Very High Very High Very High
substance P 1 93.28 High High
Neuronal nitric oxide synthase 1 90.12 High High
c fibre 3 87.44 High High
Adelta 1 85.28 High High
Spinal cord 16 78.64 Quite High
central sensitization 1 77.44 Quite High
Lasting pain 1 75.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 47 98.68 Very High Very High Very High
Hypersensitivity 10 82.60 Quite High
Pain 7 75.44 Quite High
Nociception 13 70.48 Quite High
Ganglion Cysts 32 60.32 Quite High
Dyspepsia 41 8.60 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

22 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, an antibody recognizing NR2C and NR2D labeled only neurofilament-negative DRG profiles.
NR2D Binding (recognizing) of in DRG
1) Confidence 0.30 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.08 Pain Relevance 0.24
The N-methyl-D-aspartate (NMDA) receptor subunits NR1 and NR2D and proteinase-activated receptor-2 (PAR2) were also found in these neurons.
NR2D Binding (found) of in neurons
2) Confidence 0.29 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424003 Disease Relevance 0.07 Pain Relevance 0.31
As previously reported, CANs co-localize with the NR1 and NR2D subunits of the NMDA receptor as well as with the PAR2 receptor [17].
NR2D Binding (localize) of associated with nmda receptor
3) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.65 Pain Relevance 0.38

General Comments

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