INT102281

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 10.38
Pain Relevance 20.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
dorsal horn 10
spinal cord 8
forebrain 4
DRG 4
ACC 3
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ultiva 330 100.00 Very High Very High Very High
nMDA receptor 291 100.00 Very High Very High Very High
Dorsal horn 69 100.00 Very High Very High Very High
spinal dorsal horn 57 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
long-term potentiation 356 99.96 Very High Very High Very High
depression 196 99.80 Very High Very High Very High
Anterior cingulate cortex 54 99.72 Very High Very High Very High
Morphine 33 99.62 Very High Very High Very High
amygdala 73 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 100.00 Very High Very High Very High
Depression 192 99.80 Very High Very High Very High
Brain Hemorrhage 76 99.20 Very High Very High Very High
Injury 44 99.08 Very High Very High Very High
INFLAMMATION 42 98.92 Very High Very High Very High
Neuropathic Pain 67 97.92 Very High Very High Very High
Inflammatory Pain 5 97.92 Very High Very High Very High
Hyperalgesia 282 97.64 Very High Very High Very High
Pain 97 95.64 Very High Very High Very High
Anxiety Disorder 94 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The data revealed increased expression of NR2B subunits in the superficial dorsal horn in CCD rats.
Positive_regulation (increased) of Gene_expression (expression) of NR2B in CCD
1) Confidence 0.70 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19224818 Disease Relevance 0.08 Pain Relevance 0
This hypothesis is supported by immunohistochemical and westernblotting experiments in our study showing that remifentanil significantly increased the expression of tyrosine phosphorylation of NR2B in the lamina I-II of the L4-L5 spinal cord.
Positive_regulation (increased) of Gene_expression (expression) of NR2B in spinal cord associated with ultiva and spinal cord
2) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.77 Pain Relevance 1.66
Intraoperative infusion of remifentanil significantly enhanced the expression of NR2B tyrosine phosphorylation in the superficial dorsal horn of spinal cord(P < 0.05).
Positive_regulation (enhanced) of Gene_expression (expression) of NR2B in spinal cord associated with dorsal horn, ultiva and spinal cord
3) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.24 Pain Relevance 1.13
The expression of NR2B tyrosine phosphorylation in rats receiving intraoperative remifentanil infusion was significantly upregulated when compared with rats receiving intraoperative saline infusion (P < 0.01).
Positive_regulation (upregulated) of Gene_expression (expression) of NR2B associated with ultiva
4) Confidence 0.69 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.23 Pain Relevance 1.17
Quantitative RT-PCR and Western blot analysis indicated a 28% increase in the expression of NR2B with little or no change in the other three NR2 subunits.
Positive_regulation (increase) of Gene_expression (expression) of NR2B
5) Confidence 0.67 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565418 Disease Relevance 0.58 Pain Relevance 0.21
Experimental results showed that (1) an augmented expression of NR2B subunit was revealed by Western blotting in the nucleus accumbens (NAc) and the hippocampus in rats with CPP induced by morphine, but not by natural rewards such as food, novel environment and social interaction. (2) Ifenprodil, an antagonist highly selective for NR2B subunit of the NMDA receptor, produced a dose-dependent reduction in CPP induced by morphine and novel environment, but not that by food consumption and social interaction.
Positive_regulation (augmented) of Gene_expression (expression) of NR2B in hippocampus associated with nucleus accumbens, nmda receptor, antagonist, hippocampus and morphine
6) Confidence 0.58 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16631172 Disease Relevance 0.15 Pain Relevance 0.81
In the present study, we demonstrated a reduction of Na+/K+ ATPase and increased expression of NCX1 and NR2B in the penumbra by focal cerebral ischemia.
Positive_regulation (increased) of Gene_expression (expression) of NR2B associated with brain hemorrhage and ischemia
7) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.33 Pain Relevance 0.47
We found that, in addition to a marked suppression of thermal hyperalgesia and mechanical allodynia, intrathecal injection ifenprodil treatment causes a decreased expression of NR2B in the spinal cord.
Positive_regulation (causes) of Gene_expression (expression) of NR2B in spinal cord
8) Confidence 0.47 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19224818 Disease Relevance 0.07 Pain Relevance 0
This study showed that the expression of NR2B tyrosine phosphorylation in the spinal dorsal horn increases markedly during the maintenance of the hyreralgesia induced by remifentanil and this increase can be prevented by pretreatment with ketamine.
Positive_regulation (increases) of Gene_expression (expression) of NR2B in dorsal horn associated with ketamine, spinal dorsal horn and ultiva
9) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.12 Pain Relevance 1.14
Wilson's study showed that the increased expression of NR2B in the superficial dorsal horn of animal models of neuropathic pain was attenuated following NMDA receptor antagonist pretreatment [37].
Positive_regulation (increased) of Gene_expression (expression) of NR2B in dorsal horn associated with nmda receptor antagonist, neuropathic pain and dorsal horn
10) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.59 Pain Relevance 1.64
The expression of NR2B tyrosine phosphorylation in the superficial dorsal horn of the group I, K, R, K+R was increased when compared to group C (P < 0.01).
Positive_regulation (increased) of Gene_expression (expression) of NR2B in dorsal horn associated with dorsal horn
11) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.36 Pain Relevance 1.23
The results suggest that PA upregulation of neuronal nitric oxide synthase and NR2B subunit expression in the spinal dorsal horn contributes to PA inhibition of hyperalgesia induced by chronic compression of dorsal root ganglia.
Positive_regulation (upregulation) of Gene_expression (expression) of NR2B in dorsal horn associated with hyperalgesia, spinal dorsal horn and neuronal nitric oxide synthase
12) Confidence 0.46 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.40 Pain Relevance 0.84
Real-time RT-PCR showed that NR2B and NR2D were expressed at higher levels than NR2A and NR2C in DRG.
Positive_regulation (levels) of Gene_expression (expressed) of NR2B in DRG
13) Confidence 0.46 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.09 Pain Relevance 0.25
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Positive_regulation (increased) of Gene_expression (levels) of NR2B in descending colon associated with action potential and spinal cord
14) Confidence 0.44 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46
Our results showed that chronic morphine treatment induced upregulation of the NR2B expression and activation of JNK in the spinal cord.
Positive_regulation (upregulation) of Gene_expression (expression) of NR2B in spinal cord associated with spinal cord and morphine
15) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.32
Consistently, genetic over-expression of NR2B C-terminal in the BLA, which interferes with the C-terminal mediated intracellular signaling, produced a severe deficit in auditory fear memory for five but not one CS-US pairing protocol, whereas over-expression of NR2A C-terminal produced a deficient memory for both protocols.
Positive_regulation (over) of Gene_expression (expression) of NR2B in BLA associated with anxiety disorder and amygdala
16) Confidence 0.42 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.52 Pain Relevance 0.44
However, the conclusion that NR2B-NMDAR is selectively involved in the induction of LTD but not LTP has been challenged by the studies using NR2A-knockout mice [12,13] and over-expression of NR2B-NMDARs [14], suggesting the existence of NR2A-independent forms of LTP.
Positive_regulation (using) of Gene_expression (expression) of NR2B-NMDARs associated with targeted disruption and long-term potentiation
17) Confidence 0.39 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.23 Pain Relevance 0.50
RESULTS: Long-term morphine infusion induced antinociceptive tolerance and up-regulated N-methyl-d-aspartate receptor subunits NR1 and NR2B expression in both total lysate and synaptosome fraction of the spinal cord dorsal horn.
Positive_regulation (regulated) of Gene_expression (expression) of NR2B in spinal cord dorsal horn
18) Confidence 0.39 Published 2010 Journal Anesthesiology Section Body Doc Link 20938337 Disease Relevance 0 Pain Relevance 0
To some extent, the limited selectivity of NVP may weaken our conclusion that NR2B receptors can support LTP/LTD under NVP blockade in facilitation experiments, considering that residual NR2A current would not be negligible compared to the remaining NR2B response.
Positive_regulation (support) of Gene_expression (receptors) of NR2B associated with depression and long-term potentiation
19) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1959237 Disease Relevance 0.10 Pain Relevance 0.16
Altered expression of NR2A and NR2B, which depends on the duration of focal cerebral ischemia, could play variable roles in secondary brain cell injury in the penumbra
Positive_regulation (depends) of Gene_expression (expression) of NR2B in brain associated with brain hemorrhage, ischemia and injury
20) Confidence 0.36 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.46 Pain Relevance 0.25

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