INT102288

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Context Info
Confidence 0.55
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.02
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
pyramidal neurons 2
SH-SY5Y 1
neurons 1
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 32 99.84 Very High Very High Very High
Pyramidal cell 5 99.64 Very High Very High Very High
nMDA receptor 3 99.00 Very High Very High Very High
tetrodotoxin 1 90.72 High High
Brush evoked pain 3 90.64 High High
Pain 38 90.48 High High
dorsal root ganglion 56 86.48 High High
addiction 1 81.08 Quite High
Analgesic 3 80.28 Quite High
Spinal cord 25 79.76 Quite High
Disease Link Frequency Relevance Heat
Nociception 20 99.28 Very High Very High Very High
Neuroblastoma 3 97.04 Very High Very High Very High
Neuropathic Pain 8 90.64 High High
Pain 43 90.48 High High
Ganglion Cysts 91 86.48 High High
Bordatella Infection 2 82.40 Quite High
Low Back Pain 1 75.32 Quite High
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-localization of the different P2Y receptor-subtypes with markers for nociceptive neurons showed that the P2Y1 and P2Y2 receptors are typically expressed in small, nociceptive cells, whereas the P2Y4 subtype seems to be present in large neurons involved in the transmission of tactile allodynia.
Localization (localization) of P2Y receptor in neurons associated with nociception and brush evoked pain
1) Confidence 0.55 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096565 Disease Relevance 0.77 Pain Relevance 0.69
To capture the integration of PI metabolism with P2Y-driven calcium release, we used dynamic measurements of PIPx levels in stimulated SH-SY5Y human neuroblastoma cells to constrain the PI module [49].
Localization (release) of P2Y in SH-SY5Y associated with neuroblastoma
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735677 Disease Relevance 0.17 Pain Relevance 0.07
In a recent study Rodrigues et al. demonstrated that single hippocampal pyramidal neurons do express P2Y1, P2Y2, and P2Y4 receptors, and the release of glutamate, measured by a neurochemical technique, is inhibited by these receptors [69].
Localization (release) of P2Y2 in pyramidal neurons associated with glutamate and pyramidal cell
3) Confidence 0.13 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.08 Pain Relevance 0.54
These observations suggest that in layer V pyramidal neurons of the prefrontal cortex postsynaptically localized P2Y receptors interact with NMDA receptor-channels.
Localization (localized) of P2Y in pyramidal neurons associated with nmda receptor and pyramidal cell
4) Confidence 0.08 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11955519 Disease Relevance 0 Pain Relevance 0.54

General Comments

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