INT1023

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 1996
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 0.76
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pxk) nucleus (Pxk) molecular_function (Pxk)
cellular_component (Pxk) biological_process (Pxk) cytoplasm (Pxk)
Anatomy Link Frequency
smooth muscle 1
neurons 1
heart 1
Pxk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 6 99.16 Very High Very High Very High
Pain 1 98.36 Very High Very High Very High
Morphine 5 98.04 Very High Very High Very High
tetrodotoxin 9 96.92 Very High Very High Very High
Serotonin 1 94.72 High High
Glutamate 6 94.44 High High
Clonidine 1 94.12 High High
narcan 6 91.92 High High
antagonist 2 89.44 High High
agonist 5 89.04 High High
Disease Link Frequency Relevance Heat
Stress 4 98.50 Very High Very High Very High
Heart Rate Under Development 2 95.12 Very High Very High Very High
Disease 2 93.20 High High
Arrhythmogenic Right Ventricular Dysplasia 2 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABA uptake was not affected by certain drugs inhibiting the Na,K-ATPase activity (azabuperon, tetrabenazine).
Negative_regulation (inhibiting) of Na,K-ATPase associated with gaba
1) Confidence 0.59 Published 1976 Journal Biull Eksp Biol Med Section Abstract Doc Link 129178 Disease Relevance 0 Pain Relevance 0.24
The aim of this study is to investigate the effect of ouabain (inhibitor of Na-K ATPase) in the myocardial uptake and clearance of 201Tl and 99mTc MIBI using rats.
Spec (investigate) Negative_regulation (inhibitor) of Na-K ATPase
2) Confidence 0.58 Published 1992 Journal Kaku Igaku Section Abstract Doc Link 1331578 Disease Relevance 0 Pain Relevance 0.05
A decrease in the activity of synaptosomal Na,K-ATPase was found in most cases.
Negative_regulation (decrease) of Na,K-ATPase
3) Confidence 0.51 Published 1976 Journal Biull Eksp Biol Med Section Abstract Doc Link 129178 Disease Relevance 0 Pain Relevance 0.21
Ouabain caused [3H]norepinephrine release at concentrations that produced 80 to 90% inhibition of Na,K-ATPase activity.
Negative_regulation (inhibition) of Na,K-ATPase
4) Confidence 0.43 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2993543 Disease Relevance 0 Pain Relevance 0.15
Inhibition of the Na,K-ATPase is known to cause transmitter release from many neurons.
Negative_regulation (Inhibition) of Na,K-ATPase in neurons
5) Confidence 0.43 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2993543 Disease Relevance 0 Pain Relevance 0.09
Potentiation probably resulted from a reduction in the smooth muscle membrane potential as a consequence of inhibition of Na-K ATPase.
Negative_regulation (inhibition) of Na-K ATPase in smooth muscle
6) Confidence 0.43 Published 1985 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2410710 Disease Relevance 0 Pain Relevance 0.18
At a concentration of 10(-4) M, veratridine caused depolarization of Em and a decrease in Na-K pump activity.
Negative_regulation (decrease) of Na-K
7) Confidence 0.43 Published 1990 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2163752 Disease Relevance 0 Pain Relevance 0.07
High concentrations of veratridine cause only depolarization of Em and inhibition of Na-K pump activity.
Negative_regulation (inhibition) of Na-K
8) Confidence 0.43 Published 1990 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 2163752 Disease Relevance 0 Pain Relevance 0.08
Induction of lipid peroxidation (LPO) under emotional painful stress in rats in vivo and by the Fe2+ plus ascorbate system in vitro results in inactivation of Na,K-ATPase in the sarcolemma-rich membrane fraction of the heart.
Negative_regulation (inactivation) of Na,K-ATPase in heart associated with stress and pain
9) Confidence 0.37 Published 1983 Journal Biull Eksp Biol Med Section Abstract Doc Link 6140965 Disease Relevance 0.25 Pain Relevance 0.10
These changes were not due to a reduction in mucosal Na-K-ATPase activity.
Negative_regulation (reduction) of Na-K-ATPase
10) Confidence 0.36 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6326587 Disease Relevance 0 Pain Relevance 0.74
Inhibition of Na-K-ATPase by ouabain inhibited the uptake of 201Tl-Cl (77%) and 201Tl-DDC (27%).
Negative_regulation (Inhibition) of Na-K-ATPase
11) Confidence 0.34 Published 1989 Journal Eur J Nucl Med Section Abstract Doc Link 2537215 Disease Relevance 0 Pain Relevance 0.10
Liquor cerebrospinalis appears to contain an endogenous inhibitor of synaptic Na,K-ATPase, which controls the enzymatic activity in vivo.
Negative_regulation (inhibitor) of Na,K-ATPase
12) Confidence 0.16 Published 1979 Journal Vopr. Med. Khim. Section Abstract Doc Link 218361 Disease Relevance 0.18 Pain Relevance 0
Brevetoxin-B did not inhibit guinea pig cardiac Na,K-ATPase activities.
Negative_regulation (inhibit) of Na,K-ATPase
13) Confidence 0.08 Published 1984 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6093288 Disease Relevance 0.34 Pain Relevance 0.14
The AMPA- and KA-evoked releases were blocked by 6,7-dinitroquinoxaline-2,3-dione (DNQX) or by GYKI 52466 but were insensitive to MK-801.
Negative_regulation (blocked) of KA-evoked
14) Confidence 0.01 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522949 Disease Relevance 0 Pain Relevance 0.55

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