INT102311

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.37
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6R) extracellular region (IL6R) plasma membrane (IL6R)
enzyme binding (IL6R)
Anatomy Link Frequency
spine 1
IL6R (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 121 94.36 High High
methotrexate 33 91.36 High High
cytokine 31 90.60 High High
Pain 4 76.16 Quite High
agonist 4 73.04 Quite High
Inflammation 21 68.32 Quite High
corticosteroid 9 67.68 Quite High
Arthritis 19 49.36 Quite Low
Inflammatory response 2 46.96 Quite Low
abatacept 2 19.12 Low Low
Disease Link Frequency Relevance Heat
Diverticulitis 1 99.24 Very High Very High Very High
Disease 40 99.16 Very High Very High Very High
Intestinal Perforation 1 97.52 Very High Very High Very High
Intervertebral Disk Displacement 2 96.60 Very High Very High Very High
Rheumatoid Arthritis 122 94.36 High High
Disorder Of Lipid Metabolism 11 88.00 High High
Hypercalcemia 4 81.20 Quite High
Peritonitis 1 80.80 Quite High
Bacterial Meningitis 2 77.28 Quite High
Influenza Virus Infection 2 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, serum IL-6 level was elevated specifically prior to intestinal perforation [32, 33], and it is possible that TCZ could mask the early symptoms of diverticulitis and hamper healing by its inhibitory effect on IL-6/IL-6R signaling.


Regulation (effect) of IL-6R associated with intestinal perforation and diverticulitis
1) Confidence 0.12 Published 2009 Journal Mod Rheumatol Section Body Doc Link PMC2720589 Disease Relevance 0.91 Pain Relevance 0.09
Larger randomized controlled studies are needed to determine the effects of IL-6R blockade in erosive disease.
Spec (determine) Regulation (effects) of IL-6R associated with disease
2) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.69 Pain Relevance 0.26
In these sections no immunoreaction for TGF-beta1, IL-6, or IL-6R was found, while they expressed IGF-1 and fibronectin, but in lower quantities than herniated discs.
Neg (no) Regulation (immunoreaction) of IL-6R associated with intervertebral disk displacement
3) Confidence 0.02 Published 2002 Journal Eur Spine J Section Abstract Doc Link 11956921 Disease Relevance 0.26 Pain Relevance 0.11
The change of sIL-6R was inversely associated with increase in BMD in the lumbar spine after 2 years.
Regulation (change) of sIL-6R in spine
4) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.30 Pain Relevance 0.16
was also associated weakly with the change in sIL-6R and more strongly with the alterations in IL-1Ra and ESR and inversely to a smaller extent with the change in IGF-1.
Regulation (change) of sIL-6R
5) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.20 Pain Relevance 0.12

General Comments

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