INT102316

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Context Info
Confidence 0.16
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.64

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endoplasmic reticulum (Ugt1a6a, Cyb5) enzyme binding (Ugt1a6a, Cyb5) transport (Cyb5)
mitochondrion (Cyb5) transferase activity, transferring glycosyl groups (Ugt1a6a) protein complex (Ugt1a6a)
Ugt1a6a (Mus musculus)
Cyb5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 96.00 Very High Very High Very High
analgesia 1 94.88 High High
Antinociceptive 3 87.68 High High
Disease Link Frequency Relevance Heat
Nociception 1 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nifedipine caused enzyme induction, which was demonstrated by shortened hexobarbital sleeping time, enhanced ethylmorphine-N-demethylase (EMND), aniline-4-hydroxylase (AH), ethoxycoumarine-O-deethylase (ECOD), UDP-glucuronyl transferase (UDPGT), glutathione-S-transferase (GST) and NADPH-cytochrome c reductase activity and increased content of cytochrome P450 and cytochrome b5.
UDPGT Positive_regulation (increased) of cytochrome b5
1) Confidence 0.16 Published 2001 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 11957744 Disease Relevance 0.08 Pain Relevance 0.64

General Comments

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