INT102337

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.83
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAP1A) signal transduction (RAP1A) small molecule metabolic process (RAP1A)
plasma membrane (RAP1A) GTPase activity (RAP1A)
Anatomy Link Frequency
osteoclasts 1
RAP1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 88.96 High High
headache 1 86.16 High High
Central nervous system 1 84.80 Quite High
Potency 6 44.64 Quite Low
antagonist 9 38.44 Quite Low
agonist 9 30.56 Quite Low
aspirin 2 29.84 Quite Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 99.92 Very High Very High Very High
Congenital Anomalies 6 95.28 Very High Very High Very High
Breast Cancer 81 94.16 High High
Convulsion 2 90.40 High High
Ataxia 1 89.60 High High
Vascular Malformations 1 88.00 High High
Stroke 1 86.72 High High
Headache 1 86.16 High High
Intestinal Cancer 3 75.96 Quite High
Blister 1 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mutation in exon 19 causes a premature stop codon (Q698X) predicted to produce a truncated Krev1 interaction-trapped 1 (KRIT1) protein.
Gene_expression (produce) of Krev1
1) Confidence 0.58 Published 2002 Journal J. Neurol. Sci. Section Abstract Doc Link 11959162 Disease Relevance 1.15 Pain Relevance 0.17
Based on these data, the repression of RAP1A expression by both NUP98-HOXA9 and NUP98-HOXA9/N51S may play a role in their inhibition of both erythroid and myeloid differentiation.


Gene_expression (expression) of RAP1A associated with repression
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0.22 Pain Relevance 0
mol/l ibandronate was sufficient to produce a detectable inhibition of Rap1A prenylation in the presence of 2.0 mmol/l calcium, whereas 100 ?
Gene_expression (prenylation) of Rap1A
3) Confidence 0.40 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.05 Pain Relevance 0
That study also revealed that both EGTA and clodronate prevent bisphosphonate-induced inhibition of Rap1A prenylation in J774 cells and osteoclasts.
Gene_expression (prenylation) of Rap1A in osteoclasts
4) Confidence 0.40 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.17 Pain Relevance 0
Unprenylated Rap1A and total Rap1 were determined by Western blotting.
Spec (determined) Gene_expression (determined) of Rap1A
5) Confidence 0.40 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.24 Pain Relevance 0

General Comments

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