INT102341

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc6a3, Flvcr2) transmembrane transport (Slc6a3, Flvcr2) aging (Slc6a3)
Anatomy Link Frequency
vesicle 1
Slc6a3 (Rattus norvegicus)
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 41 99.72 Very High Very High Very High
monoamine 2 95.76 Very High Very High Very High
Serotonin 3 85.32 High High
Potency 2 76.00 Quite High
antidepressant 2 36.40 Quite Low
fluoxetine 2 34.32 Quite Low
addiction 1 25.00 Low Low
depression 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 7 5.00 Very Low Very Low Very Low
Endometriosis (extended) 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Starvation 2 5.00 Very Low Very Low Very Low
Pheochromocytoma 2 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most compounds in this series possessed a very low activity at the DA transporter (DAT) but a good to excellent affinity for the 5-HT transporter (SERT).
DAT Binding (affinity) of transporter associated with dopamine
1) Confidence 0.06 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 11960503 Disease Relevance 0 Pain Relevance 0.34
An Ab to the second extracellular loop of DAT recognizes transporter which is either on the plasma membrane or inside the cell, but not vesicle-bound (in which case the 2nd loop would be facing the inaccessible vesicle interior).
DAT Binding (recognizes) of transporter in vesicle
2) Confidence 0.00 Published 2006 Journal J Mol Signal Section Body Doc Link PMC1769494 Disease Relevance 0 Pain Relevance 0

General Comments

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