INT102348

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.18
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
neurons 2
macrophage 1
spleen 1
central nervous system 1
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 42 100.00 Very High Very High Very High
antagonist 18 99.88 Very High Very High Very High
agonist 14 99.84 Very High Very High Very High
Root ganglion neuron 1 99.70 Very High Very High Very High
Inflammatory response 10 98.08 Very High Very High Very High
Inflammation 51 97.80 Very High Very High Very High
Neuropeptide 1 95.68 Very High Very High Very High
cytokine 17 95.04 Very High Very High Very High
Thermal hyperalgesia 2 95.04 Very High Very High Very High
Opioid 1 94.96 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 63 99.84 Very High Very High Very High
Ganglion Cysts 1 99.54 Very High Very High Very High
INFLAMMATION 56 98.08 Very High Very High Very High
Hyperalgesia 2 95.04 Very High Very High Very High
Pressure And Volume Under Development 6 94.52 High High
Pain 3 84.92 Quite High
Obesity 1 75.52 Quite High
Pneumonia 13 75.12 Quite High
Hypersensitivity 1 75.00 Quite High
Stroke 4 70.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PPADS is a purinergic receptor antagonist that acts on P2Y2 and P2Y4 [15], while extracellular ATP has been observed to induce chemotaxis of microglia, which acts as an innate immune system in the central nervous system, mediated by the P2X4 and P2Y12 receptors [30].
Regulation (acts) of P2Y2 in central nervous system associated with antagonist and central nervous system
1) Confidence 0.40 Published 2008 Journal Respir Res Section Body Doc Link PMC2627837 Disease Relevance 0.75 Pain Relevance 0.37
Despite the emerging literature that suggests a role for P2Y receptors in macrophage-mediated migration and inflammatory responses, a clear understanding of the selective agonists of these receptors and their interplay with each other and non-P2Y receptors is lacking.
Regulation (role) of P2Y in macrophage associated with inflammatory response and agonist
2) Confidence 0.39 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.16 Pain Relevance 0.19
Patch-clamp analyses using mouse dorsal root ganglion neurons indicated the involvement of P2Y2 rather than P2Y1 receptors.
Regulation (involvement) of P2Y2 in neurons associated with ganglion cysts and root ganglion neuron
3) Confidence 0.30 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.52 Pain Relevance 0.53
This does not preclude, however, that P2Y2 and P2X1 receptor function could be altered in diabetic patients.
Regulation (altered) of P2Y2 associated with diabetes mellitus
4) Confidence 0.20 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.75 Pain Relevance 0.06
The lack of P2Y2 and P2Y4 immunoreactivity in neurons was confirmed by quantification of fluorescence images using the criterion that the average intensity of a positively stained cell should be greater than average intensity +3 SD of cells that were incubated with secondary antibody alone, as described in the Materials and methods.
Regulation (immunoreactivity) of P2Y2 in neurons
5) Confidence 0.10 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
In this study, we describe the role of exogenous and endogenous adenosine and exogenous P2X(1) and P2Y(1) agonists for spontaneous splenic IL-6 secretion from spleen slices.
Regulation (role) of P2Y in spleen associated with adenocard and agonist
6) Confidence 0.02 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960643 Disease Relevance 0 Pain Relevance 0.61

General Comments

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