INT102351

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 7
Total Number 19
Disease Relevance 22.45
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
hippocampus 5
neuronal 1
dentate gyrus 1
blood vessel 1
endothelial cell 1
Pecam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 36 100.00 Very High Very High Very High
ischemia 702 99.84 Very High Very High Very High
allodynia 8 99.80 Very High Very High Very High
Hippocampus 208 99.40 Very High Very High Very High
cytokine 19 99.12 Very High Very High Very High
Inflammation 190 98.72 Very High Very High Very High
dorsal root ganglion 45 98.60 Very High Very High Very High
Pyramidal cell 52 97.48 Very High Very High Very High
Sciatic nerve 15 92.20 High High
Neurotransmitter 2 91.28 High High
Disease Link Frequency Relevance Heat
Stress 652 100.00 Very High Very High Very High
Adhesions 81 100.00 Very High Very High Very High
Cv Unclassified Under Development 546 99.84 Very High Very High Very High
Neuropathic Pain 20 99.80 Very High Very High Very High
Shock 3 99.52 Very High Very High Very High
Transient Ischemic Attack 130 98.80 Very High Very High Very High
INFLAMMATION 193 98.72 Very High Very High Very High
Ganglion Cysts 46 98.60 Very High Very High Very High
Disease 31 98.24 Very High Very High Very High
Death 132 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in the present study, we investigated the effects of stress on ischemic damage, and PECAM-1 immunoreactivity and protein levels in the gerbil hippocampus following 5 minutes of transient cerebral ischemia.


Spec (investigated) Regulation (immunoreactivity) of PECAM-1 in hippocampus associated with stress, transient ischemic attack, ischemia and hippocampus
1) Confidence 0.61 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.80 Pain Relevance 0.20
To confirm changes in PECAM-1 levels in the hippocampus following transient cerebral ischemia, sham- and ischemia-operated animals in both control and stress groups (n=7 at each time point) were used for western blot analysis at 4 days after ischemia/reperfusion.
Regulation (changes) of PECAM-1 in hippocampus associated with stress, transient ischemic attack, ischemia and hippocampus
2) Confidence 0.61 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 0.38 Pain Relevance 0.26
Endothelial genes CD31 and VE-cadherin, which function in endothelial cell homeostasis and integrity, were not affected during the shock phase except for VE-cadherin in the liver, which showed increased mRNA levels.
Neg (not) Regulation (affected) of CD31 in endothelial cell associated with shock
3) Confidence 0.46 Published 2008 Journal Shock Section Abstract Doc Link 17704730 Disease Relevance 1.52 Pain Relevance 0.26
In the present study, we observed the changes of PECAM-1 immunoreactivity and protein levels in the hippocampus of control- and stress-groups after transient cerebral ischemia.
Regulation (changes) of PECAM-1 in hippocampus associated with stress, transient ischemic attack, ischemia and hippocampus
4) Confidence 0.45 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.46 Pain Relevance 0.31
Qualitative analysis indicated no differences in the CD31+ blood vessel density in L3 to L5 DRG.
Neg (no) Regulation (differences) of CD31 in blood vessel associated with dorsal root ganglion
5) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2289805 Disease Relevance 0.63 Pain Relevance 0.38
In this study, we investigated the effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 (PECAM-1), a very important mediator in inflammation, immunoreactivity and protein levels as well as neuronal damage, in the gerbil hippocampus after 5 minutes of transient cerebral ischemia.
Spec (investigated) Regulation (effects) of PECAM-1 in platelet associated with stress, transient ischemic attack, inflammation, ischemia, hippocampus and adhesions
6) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998780 Disease Relevance 1.35 Pain Relevance 0.41
Changes in PECAM-1 immunoreactivity
Regulation (Changes) of PECAM-1
7) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.27 Pain Relevance 0.41
In the ischemia-group, PECAM-1 immunoreactivity and its protein levels were significantly increased in all the hippocampal subregions 4 days after ischemia/reperfusion.
Regulation (immunoreactivity) of PECAM-1 associated with ischemia
8) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998780 Disease Relevance 1.55 Pain Relevance 0.53
In the western blot study, we found that changes in PECAM-1 protein levels in the gerbil hippocampus after ischemia/reperfusion were generally similar to the immunohistochemical change.
Regulation (changes) of PECAM-1 in hippocampus associated with ischemia and hippocampus
9) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.56 Pain Relevance 0.62
In addition, we observed a considerable increase of PECAM-1 immunoreactivity in the CA1 region of the ischemia-group, compared to a moderate increase in the CA2/3 region and dentate gyrus.
Regulation (immunoreactivity) of PECAM-1 in dentate gyrus associated with ischemia
10) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.02 Pain Relevance 0.33
Changes in PECAM-1 protein levels
Regulation (Changes) of PECAM-1
11) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.46 Pain Relevance 0.59
In the ischemia-group, both PECAM-1 immunoreactivity and protein levels were significantly increased in all the hippocampal subregions 4 days after ischemia/reperfusion.
Regulation (immunoreactivity) of PECAM-1 associated with ischemia
12) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.29 Pain Relevance 0.30
These results indicate that the fact that we detected no significant changes in PECAM-1 may be connected to the effects of repeated restraint stress and ischemic damage.



Neg (no) Regulation (changes) of PECAM-1 associated with stress
13) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.23 Pain Relevance 0.42
However, PECAM-1 immunoreactivity and its protein levels did not change significantly in the hippocampus of the stress-ischemia-group compared to the sham-groups.
Regulation (immunoreactivity) of PECAM-1 in hippocampus associated with stress, ischemia and hippocampus
14) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998780 Disease Relevance 1.51 Pain Relevance 0.52
As mentioned previously, inflammation and infiltration of inflammatory cells are thought to be important factors in ischemia-induced neuronal damage (Gautier et al., 2009; Hendryk et al., 2010); therefore, the fact that there were no significant changes in PECAM-1 immunoreactivity and protein levels in the stress-ischemia-group may be related to the blockade of inflammatory events such as infiltration of inflammatory cells.
Neg (no) Regulation (changes) of PECAM-1 in neuronal associated with stress, inflammation and ischemia
15) Confidence 0.27 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.57 Pain Relevance 0.53
/CD31+) cell populations. a The amount of Sca+/CD31?
Regulation (populations.) of CD31
16) Confidence 0.27 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.61 Pain Relevance 0.03
Intraplantar zymosan produced transient allodynia and only PECAM and ICAM immunoreactivity.
Regulation (immunoreactivity) of PECAM associated with allodynia
17) Confidence 0.23 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.05 Pain Relevance 0.62
In contrast, persistent mechanical allodynia and enhanced spinal PECAM, ICAM, MHC class II and CD4 immunoreactivity was observed following peripheral nerve transection.
Regulation (immunoreactivity) of PECAM in peripheral nerve associated with allodynia
18) Confidence 0.23 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.05 Pain Relevance 0.64
Marked alterations in expressio n of immunomodulator mRNA, including C-C chemokine RANTES, C-C chemokine receptors CCR1, CCR3 and CCR5, adhesion molecules PECAM-1, ICAM-1, and VCAM-1, cytokines IF N-gamma, TNF-alpha, IL-12, IL-4, and iNOS were observed to be up-regulated, while growth factors, GDF-2 and TGF-beta precursor, were down-regulated (Table 2, P < 0.05) at peak parasitaemia.


Regulation (alterations) of PECAM-1 associated with chemokine, adhesions and cytokine
19) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.13 Pain Relevance 0.23

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