INT102353

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.07
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA2) Golgi apparatus (HLA-DQA2) endoplasmic reticulum (HLA-DQA2)
plasma membrane (HLA-DQA2)
Anatomy Link Frequency
peripheral nerve 1
cornea 1
dental pulp 1
HLA-DQA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 4 99.90 Very High Very High Very High
Inflammation 64 97.28 Very High Very High Very High
cytokine 46 79.64 Quite High
Neuropathic pain 2 75.44 Quite High
pulpitis 1 51.84 Quite High
Sicca syndrome 21 39.88 Quite Low
abdominal pain 12 27.92 Quite Low
neuralgia 1 25.00 Low Low
Arthritis 3 22.40 Low Low
depression 4 21.52 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.90 Very High Very High Very High
Celiac Disease 130 98.04 Very High Very High Very High
INFLAMMATION 65 97.28 Very High Very High Very High
Injury 1 94.00 High High
Congenital Anomalies 4 93.88 High High
Disease 53 93.52 High High
Targeted Disruption 10 92.64 High High
Adhesions 5 91.80 High High
Hyperplasia 5 86.84 High High
Osteoporosis 16 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirty-six patients (80%) had HLA DQ2, and 2 patients (4.4%) had DQ8.
Positive_regulation (had) of HLA DQ2
1) Confidence 0.06 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.03 Pain Relevance 0
Four patients (8.8%) were positive for both HLA DQ2 and HLA DQ8.


Positive_regulation (positive) of HLA DQ2
2) Confidence 0.06 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.05 Pain Relevance 0
Concurrently, CD86high cells expressing intermediate levels of CD11c and high levels of MHC class II and F4/80, assessed by using flow cytometry, increased significantly in the regional lymph nodes, suggesting migration of these cells from the dental pulp.
Positive_regulation (levels) of MHC class II in dental pulp
3) Confidence 0.06 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16849394 Disease Relevance 0.23 Pain Relevance 0.05
In contrast, persistent mechanical allodynia and enhanced spinal PECAM, ICAM, MHC class II and CD4 immunoreactivity was observed following peripheral nerve transection.
Positive_regulation (enhanced) of MHC class II in peripheral nerve associated with allodynia
4) Confidence 0.02 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 11960644 Disease Relevance 1.05 Pain Relevance 0.63
Interestingly, the dynamic of activated MHC class II+ DCs was nearly identical to that of CD4+ T cells, peaking first in the limbus at eight weeks with maximum infiltration of the cornea by 16 weeks.
Positive_regulation (activated) of MHC class II in cornea
5) Confidence 0.01 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2660375 Disease Relevance 0.21 Pain Relevance 0
In addition, cells expressing high levels of molecules involved in antigen presentation such as MHC class II, CD11c, and CD68 were elevated [165].
Positive_regulation (elevated) of MHC class II
6) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.50 Pain Relevance 0.14

General Comments

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