INT102355

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.20
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1)
response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)
Anatomy Link Frequency
proximal 1
HSP90AA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 93.44 High High
Potency 15 76.20 Quite High
Arthritis 1 49.20 Quite Low
abdominal pain 1 45.96 Quite Low
Angina 1 45.04 Quite Low
imagery 5 38.56 Quite Low
antagonist 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 56 100.00 Very High Very High Very High
Nephritis 3 100.00 Very High Very High Very High
Cancer 349 99.84 Very High Very High Very High
Breast Cancer 183 98.84 Very High Very High Very High
Stress 16 98.16 Very High Very High Very High
Necrosis 1 96.88 Very High Very High Very High
Apoptosis 24 96.44 Very High Very High Very High
Fibrosis 1 93.44 High High
Malignant Neoplastic Disease 5 90.32 High High
Proteinuria 3 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that clinical presentation of HSPN in adults is severe and its outcome relatively poor, worse than in children.
Gene_expression (presentation) of HSPN associated with nephritis
1) Confidence 0.51 Published 2002 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 11961015 Disease Relevance 1.33 Pain Relevance 0.05
Hsp90, one of the most studied molecular chaperons, is overexpressed in tumor cells and is essential for the stability and function of a wide range of oncogenic client proteins [4].
Gene_expression (overexpressed) of Hsp90 associated with cancer
2) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.80 Pain Relevance 0
HSP90 is a ubiquitously expressed molecular chaperone playing an important role in the post-translational conformational maturation and activation of a large number of client proteins that have been implicated in oncogenesis [6].
Gene_expression (expressed) of HSP90
3) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.79 Pain Relevance 0
NVP-AUY922 induces HSP90-p23 dissociation and client protein depletion in a concentration- and time-dependent manner
Gene_expression (dissociation) of HSP90-p23
4) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.46 Pain Relevance 0
In an attempt to understand the differential cellular response of HSP90 inhibition by NVP-AUY922, the expression levels of HSP90, HSP70, various client proteins (EGFR1/Her1, ERBB2, AKT, and ER), and those involved in apoptotic responses (Bax, Bad, and Bcl-XL) were determined (Figure 1a).
Spec (determined) Gene_expression (expression) of HSP90 associated with apoptosis
5) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.61 Pain Relevance 0.03
However, short-term exposure at high drug concentrations may cause potent HSP90 inhibition in cells that are highly dependent on HSP90, such as tumors [34].
Gene_expression (dependent) of HSP90 associated with cancer
6) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.58 Pain Relevance 0.04
A single dose of 8.3 or 25 mg/kg was administered and tumors were dissected 6 hours later since HSP90-p23 dissociation and AKT phosphorylation are easily detectable at this time point (Figure 2b).
Gene_expression (dissociation) of HSP90-p23 associated with cancer
7) Confidence 0.41 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.28 Pain Relevance 0
While proposing the role of Akt in downregulating Hsp70 by Resveratrol in K562 cells we contradicted the observation of induction of stress response by 17AAG, a drug that is also known to lower Akt levels (Fig. 4A) by virtue of its action on Hsp90. 17AAG was found to reduce ser473 phosphorylation of Akt and ser9 phosphorylation of Gsk3?
Gene_expression (action) of Hsp90 associated with stress
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.10 Pain Relevance 0
One of the few described mRNAs from the terminal 1 Mb of 4q is AY956760 (590-kb proximal to the D4Z4 array), the reported product of the heat shock protein gene HSP90AA4P.
Gene_expression (product) of heat shock protein gene HSP90AA4P in proximal associated with shock
9) Confidence 0.06 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox