INT102363

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.99
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
nucleus accumbens 2
visceral 2
Caco-2 2
iris 2
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 24 100.00 Very High Very High Very High
Nucleus accumbens 5 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
Glutamate 4 99.96 Very High Very High Very High
cocaine 1 99.92 Very High Very High Very High
gABA 4 99.40 Very High Very High Very High
withdrawal 1 98.92 Very High Very High Very High
opiate 2 98.48 Very High Very High Very High
Dopamine 1 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 2 97.88 Very High Very High Very High
Stress 1 97.64 Very High Very High Very High
Pancreatitis 2 84.64 Quite High
Abdominal Pain 1 82.00 Quite High
Pain 6 78.00 Quite High
Opiate Addiction 3 75.00 Quite High
Headache 1 28.24 Quite Low
Arrhythmia Under Development 1 25.00 Low Low
Akathisia 1 25.00 Low Low
Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preclinical studies suggest that visceral afferents constitutively express kappa-opioid receptors (KORs) and that noxious visceral stimuli can be inhibited at a peripheral site by KOR activation.
Negative_regulation (inhibited) of Positive_regulation (activation) of KOR in visceral associated with kappa opioid receptor
1) Confidence 0.43 Published 2003 Journal Pain Section Abstract Doc Link 12507703 Disease Relevance 0.58 Pain Relevance 0.90
KOR activation by its endogenous ligand dynorphin A(1-17) decreases basal and drug-induced striatal levels of dopamine.
Negative_regulation (decreases) of Positive_regulation (activation) of KOR associated with dopamine, dynorphin and kappa opioid receptor
2) Confidence 0.40 Published 2004 Journal Pharmacogenetics Section Abstract Doc Link 15608558 Disease Relevance 0.24 Pain Relevance 0.67
Naltrexone did not alter rKOR mRNA levels or translational efficiency, and rKOR up-regulation was not inhibited by cycloheximide.
Negative_regulation (inhibited) of Neg (not) Positive_regulation (up-regulation) of rKOR
3) Confidence 0.37 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17720886 Disease Relevance 0 Pain Relevance 0.34
Furthermore, the JNK activation in response to kappa-opioid receptor was suppressed by an autophosphorylation-resistant mutant of focal adhesion kinase (FAK).
Negative_regulation (suppressed) of Positive_regulation (activation) of kappa-opioid receptor associated with kappa opioid receptor and adhesions
4) Confidence 0.23 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.17 Pain Relevance 0.47
Activation of the kappa-opioid receptor in Caco-2 cells decreases interleukin-8 secretion.
Negative_regulation (decreases) of Positive_regulation (Activation) of kappa-opioid receptor in Caco-2 associated with kappa opioid receptor
5) Confidence 0.17 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 12706459 Disease Relevance 0 Pain Relevance 0.31
Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms.
Negative_regulation (inhibits) of Positive_regulation (activation) of Kappa opioid receptor in nucleus accumbens associated with nucleus accumbens, gaba, glutamate and kappa opioid receptor
6) Confidence 0.03 Published 2003 Journal J. Neurophysiol. Section Title Doc Link 12740400 Disease Relevance 0 Pain Relevance 1.20
Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.
Negative_regulation (Inhibition) of Positive_regulation (activation) of kappa-receptor in iris associated with kinase c
7) Confidence 0.03 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11961062 Disease Relevance 0 Pain Relevance 0.35

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