INT102379

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Context Info
Confidence 0.51
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.23
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
platelet 1
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
depression 1 100.00 Very High Very High Very High
Analgesic 17 99.70 Very High Very High Very High
cva 2 99.22 Very High Very High Very High
tail-flick 2 97.52 Very High Very High Very High
cINOD 26 96.52 Very High Very High Very High
Inflammation 33 92.68 High High
Pain 15 91.44 High High
aspirin 3 88.36 High High
agonist 3 88.00 High High
Disease Link Frequency Relevance Heat
Depression 1 100.00 Very High Very High Very High
Toxicity 5 99.04 Very High Very High Very High
Injury 3 98.04 Very High Very High Very High
Lung Cancer 79 96.72 Very High Very High Very High
INFLAMMATION 44 96.28 Very High Very High Very High
Hypertension 1 91.68 High High
Pain 15 91.44 High High
Aneurism 2 91.16 High High
Atherosclerosis 3 90.36 High High
Vasculitis 1 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A new class of analgesic agents toward prostacyclin receptor inhibition: synthesis, biological studies and QSAR analysis of 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines.
Negative_regulation (inhibition) of prostacyclin receptor associated with analgesic
1) Confidence 0.51 Published 2008 Journal Eur J Med Chem Section Title Doc Link 17804120 Disease Relevance 0.35 Pain Relevance 0.79
By studying the structural similarity of analgesic imidazolines and 2-phenylnitronyl nitroxides, 20 1-hydroxyl-2-substituted phenyl-4,4,5,5-tetramethylimidazolines (2a-t) were newly synthesized as selective antagonists of prostacyclin receptor (IP receptor).
Negative_regulation (antagonists) of prostacyclin receptor associated with antagonist and analgesic
2) Confidence 0.43 Published 2008 Journal Eur J Med Chem Section Abstract Doc Link 17804120 Disease Relevance 0.35 Pain Relevance 0.36
Here we show that injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist.
Negative_regulation (deficient) of PGI2 receptor in platelet associated with antagonist and injury
3) Confidence 0.35 Published 2002 Journal Science Section Abstract Doc Link 11964481 Disease Relevance 0.19 Pain Relevance 0.33
In our study, however, both PGE2- and PGI2-induced potentiation of TRPV1 activity was completely inhibited by treatments with two kinds of PKC inhibitors.
Negative_regulation (inhibited) of PGI2
4) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.26 Pain Relevance 0.39
This appears to be consequent to inhibition of PGI2 and PGE2 formed by cyclooxygenase-2 (COX-2).
Negative_regulation (inhibition) of PGI2
5) Confidence 0.13 Published 2008 Journal J. Intern. Med. Section Abstract Doc Link 18410593 Disease Relevance 0.95 Pain Relevance 0.40
In a chemical carcinogenesis model, lack of IP did
Negative_regulation (lack) of IP
6) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.60 Pain Relevance 0.03
overexpressing PGIS were crossed with mice deficient in IP (A.
Negative_regulation (deficient) of IP
7) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.56 Pain Relevance 0.03
The cardiovascular toxicity of COXibs has been ascribed to their selective depression of prostacyclin levels [72].
Negative_regulation (depression) of prostacyclin associated with toxicity and depression
8) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.96 Pain Relevance 0.34

General Comments

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