INT102387

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Context Info
Confidence 0.09
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.37

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plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
plasma 2
brain stem 2
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 6 99.70 Very High Very High Very High
Clonidine 2 92.08 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 4 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with AS-ODN significantly reduced the levels of alpha2A-AR mRNA in the brain stem.
Negative_regulation (reduced) of Transcription (levels) of alpha2A-AR in brain stem
1) Confidence 0.09 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.09 Pain Relevance 0.19
Taken together, the data indicate that administration of AS-ODN against alpha2A-ARs in the LC significantly reduced expression of alpha2A-AR mRNA in brain stem, moderately increased plasma corticosterone and had anxiolytic-like effect in the elevated plus-maze.
Negative_regulation (reduced) of Transcription (expression) of alpha2A-AR in plasma associated with locus ceruleus and anxiety disorder
2) Confidence 0.09 Published 2002 Journal Psychoneuroendocrinology Section Abstract Doc Link 11965357 Disease Relevance 0.15 Pain Relevance 0.19

General Comments

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