INT10240

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 0
Speculated 7
Reported most in Abstract
Documents 58
Total Number 66
Disease Relevance 22.11
Pain Relevance 24.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
neurons 10
nerve 6
neuronal 5
neurites 4
dorsal root ganglion 4
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 225 100.00 Very High Very High Very High
Nerve growth factor 188 100.00 Very High Very High Very High
trigeminal ganglion 108 100.00 Very High Very High Very High
calcitonin gene related peptide 42 100.00 Very High Very High Very High
Calcitonin gene-related peptide 28 100.00 Very High Very High Very High
Dopamine 9 100.00 Very High Very High Very High
Enkephalin 8 99.96 Very High Very High Very High
bDMF 864 99.84 Very High Very High Very High
qutenza 100 99.80 Very High Very High Very High
dorsal root ganglion 27 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 170 100.00 Very High Very High Very High
Injury 393 99.88 Very High Very High Very High
Targeted Disruption 30 99.76 Very High Very High Very High
Contusions 52 99.74 Very High Very High Very High
Nociception 16 99.70 Very High Very High Very High
Spinal Cord Injury 264 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 763 98.92 Very High Very High Very High
Pancreatitis 8 98.90 Very High Very High Very High
Cv Unclassified Under Development 414 98.76 Very High Very High Very High
Adhesions 6 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional posterior condylar displacement led to a diminution in proliferative cells, reduction in cartilage width, and re-expression of GAP-43-immunoreactive nerve fibers.
Gene_expression (expression) of GAP-43-immunoreactive in nerve
1) Confidence 0.78 Published 2004 Journal Angle Orthod Section Abstract Doc Link 15529504 Disease Relevance 0.29 Pain Relevance 0.15
Axotomy of primary sensory neurons or the interruption of axon transport in the periphery therefore acts to trigger GAP-43 production in the cell body.
Gene_expression (production) of GAP-43 in primary sensory neurons
2) Confidence 0.78 Published 1990 Journal Neuroscience Section Abstract Doc Link 2139720 Disease Relevance 0.36 Pain Relevance 0.53
Additionally, a subset of small dorsal root ganglion neurones expressed elevated levels of the growth-associated protein-43 (GAP-43) in situ.
Gene_expression (expressed) of GAP-43 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.78 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1475048 Disease Relevance 0.46 Pain Relevance 0.58
Additionally, a subset of small dorsal root ganglion neurones expressed elevated levels of the growth-associated protein-43 (GAP-43) in situ.
Gene_expression (expressed) of growth-associated protein-43 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.78 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1475048 Disease Relevance 0.46 Pain Relevance 0.57
Increased expression of GAP-43 in small sensory neurons after stimulation by NGF indicative of neuroregeneration in capsaicin-treated rats.
Gene_expression (expression) of GAP-43 in sensory neurons associated with qutenza
5) Confidence 0.78 Published 1999 Journal Regul. Pept. Section Title Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.56
In situ hybridization histochemistry (ISH) revealed that at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small DRG cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase of GAP-43 expression in the small-sized cell population.
Gene_expression (expression) of GAP-43 associated with qutenza
6) Confidence 0.78 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.58
In situ hybridization histochemistry (ISH) revealed that at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small DRG cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase of GAP-43 expression in the small-sized cell population.
Gene_expression (expression) of GAP-43 associated with qutenza
7) Confidence 0.78 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10511462 Disease Relevance 0 Pain Relevance 0.64
PLF is strongly related to the downregulation of GAP43 and CGRP expression.
Gene_expression (expression) of GAP43 associated with calcitonin gene-related peptide
8) Confidence 0.77 Published 2010 Journal Eur Spine J Section Abstract Doc Link 20012755 Disease Relevance 0.17 Pain Relevance 0.67
Expression of PKC substrate proteins, GAP-43 and neurogranin, is downregulated by cAMP signaling and alterations in synaptic activity.
Gene_expression (Expression) of GAP-43
9) Confidence 0.77 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 18005072 Disease Relevance 0 Pain Relevance 0.18
The present study tests colocalization of CGRP, associated with nociceptive neurons, with growth-associated protein (GAP-43), expressed in growing neurites, to test for neurite sprouting as a mechanism for reorganization of pain pathways at the level of the lesion and distant segments.
Gene_expression (expressed) of GAP-43 in neurites associated with nociception and pain
10) Confidence 0.76 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14637107 Disease Relevance 0.45 Pain Relevance 0.31
The present study tests colocalization of CGRP, associated with nociceptive neurons, with growth-associated protein (GAP-43), expressed in growing neurites, to test for neurite sprouting as a mechanism for reorganization of pain pathways at the level of the lesion and distant segments.
Gene_expression (expressed) of growth-associated protein in neurites associated with nociception and pain
11) Confidence 0.76 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14637107 Disease Relevance 0.46 Pain Relevance 0.31
We found that GAP-43 expression increased 3-fold, peaking between 7 and 14 days after development of the CCI.
Gene_expression (expression) of GAP-43 associated with eae
12) Confidence 0.74 Published 1994 Journal Pain Section Abstract Doc Link 7526320 Disease Relevance 0.60 Pain Relevance 0.70
Effect of FK506 on neurotransmitter content and expression of GAP-43 in neurotoxin-lesioned peripheral sensory and sympathetic neurons.
Gene_expression (expression) of GAP-43 in sympathetic associated with neurotransmitter and qutenza
13) Confidence 0.73 Published 2002 Journal Pharmacology Section Title Doc Link 12169765 Disease Relevance 0 Pain Relevance 0.64
Both types of nerve fibres expressed substance P, but only non-vessel-associated fibres expressed GAP43.
Gene_expression (expressed) of GAP43 in nerve
14) Confidence 0.73 Published 1997 Journal Lancet Section Body Doc Link 9250186 Disease Relevance 0 Pain Relevance 0
Here, we also determined the effects on the expression of two other genes (synaptophysin and growth-associated protein-43 (GAP-43)) known to be involved in synapse formation and axonal growth and likely regulated by BDNF.
Spec (determined) Gene_expression (expression) of GAP-43 in synapse
15) Confidence 0.73 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.50
Extracorporeal shockwaves induce the expression of ATF3 and GAP-43 in rat dorsal root ganglion neurons.
Gene_expression (expression) of GAP-43 in dorsal root ganglion associated with ganglion cysts, nociceptor and root ganglion neuron
16) Confidence 0.72 Published 2006 Journal Auton Neurosci Section Title Doc Link 16716760 Disease Relevance 0.50 Pain Relevance 0.75
Intense SMI32 immunostaining was observed during the first week after avulsion, appearing in 37% (+/-0.9) of surviving motoneurons, but it was not associated with GAP43 expression.
Gene_expression (expression) of GAP43 in motoneurons
17) Confidence 0.69 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.05
The regional expression of proteins associated with axonal elongation, such as microtubule-associated protein 1B (MAP1B), its phosphorylated isoform (MAP1B-P), growth-associated protein 43 (GAP-43), and polysialylated neural cell-adhesion molecule (PSA-NCAM), was examined using immunohistochemistry from 24 hours to 2 months following lateral fluid percussion brain injury of moderate severity (2.4-2.6 atmospheres) in anesthetized rats.
Spec (examined) Gene_expression (expression) of GAP-43 in neural associated with brain injury and adhesions
18) Confidence 0.69 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10906717 Disease Relevance 0.51 Pain Relevance 0.25
Of the FG-labeled neurons, the proportions of GAP43- and CGRP-immunoreactive (IR) neurons in Group A were significantly higher than in Group D (P < 0.05).
Gene_expression (proportions) of GAP43 in neurons associated with calcitonin gene-related peptide
19) Confidence 0.67 Published 2010 Journal Eur Spine J Section Abstract Doc Link 20012755 Disease Relevance 0.45 Pain Relevance 0.78
The proportions of GAP43- and CGRP-IR neurons in bone union rats in Group B were significantly lower than in nonunion rats in Group B and in the rats in Group A (P < 0.05).
Gene_expression (proportions) of GAP43 in neurons associated with calcitonin gene-related peptide
20) Confidence 0.67 Published 2010 Journal Eur Spine J Section Abstract Doc Link 20012755 Disease Relevance 0.38 Pain Relevance 0.82

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox