INT10241

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 9.89
Pain Relevance 8.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
sciatic nerve 4
neurons 4
dorsal root ganglion 3
nerve 2
midbrain 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 8 99.84 Very High Very High Very High
Sciatic nerve 368 99.70 Very High Very High Very High
dorsal root ganglion 24 99.60 Very High Very High Very High
Peripheral nervous system 2 99.60 Very High Very High Very High
bDMF 1071 99.58 Very High Very High Very High
midbrain 1 99.32 Very High Very High Very High
Peripheral nerve injury 15 98.66 Very High Very High Very High
Nerve growth factor 32 97.44 Very High Very High Very High
Dorsal horn 19 97.40 Very High Very High Very High
Root ganglion neuron 2 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sciatic Neuropathy 160 99.84 Very High Very High Very High
Ganglion Cysts 33 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 99.44 Very High Very High Very High
Targeted Disruption 7 99.42 Very High Very High Very High
Nervous System Injury 64 99.32 Very High Very High Very High
Apoptosis 63 98.28 Very High Very High Very High
Sensation Disorders 2 95.24 Very High Very High Very High
Nociception 10 94.72 High High
Hyperalgesia 3 94.04 High High
Disease 13 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the CNS the elevated GAP-43 levels may contribute to an inappropriate synaptic reorganization of afferent terminals that could play a role in the sensory disorders that follow nerve injury.
Positive_regulation (elevated) of GAP-43 in nerve associated with nervous system injury and sensation disorders
1) Confidence 0.70 Published 1990 Journal Neuroscience Section Abstract Doc Link 2139720 Disease Relevance 0.53 Pain Relevance 0.48
We report significant bilateral increases in GAP-43-IR at C8, T13, and L5 segments in lamina I through IV, at 3 days post hemisection, compared to control tissue (P < 0.05), some of which is colocalized with alpha-CGRP.
Positive_regulation (increases) of GAP-43-IR in lamina
2) Confidence 0.68 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14637107 Disease Relevance 0.40 Pain Relevance 0.29
Induction of GAP-43 modulates neuroplasticity in PBSC (CD34+) implanted-Parkinson's model.
Positive_regulation (Induction) of GAP-43
3) Confidence 0.65 Published 2009 Journal J. Neurosci. Res. Section Title Doc Link 19235891 Disease Relevance 0.43 Pain Relevance 0.06
By 48 hours postinjury, GAP-43 was elevated bilaterally within the inner molecular layers of the dentate gyrus (P < 0.005) and within the stratum lacunosum moleculare (P < 0.01), the stratum radiatum (P < 0. 005), and the stratum oriens (P < 0.05) of the hippocampus.
Positive_regulation (elevated) of GAP-43 in hippocampus associated with hippocampus
4) Confidence 0.61 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10906717 Disease Relevance 0.49 Pain Relevance 0.35
Additionally, a subset of small dorsal root ganglion neurones expressed elevated levels of the growth-associated protein-43 (GAP-43) in situ.
Positive_regulation (elevated) of GAP-43 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.50 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1475048 Disease Relevance 0.46 Pain Relevance 0.57
Additionally, a subset of small dorsal root ganglion neurones expressed elevated levels of the growth-associated protein-43 (GAP-43) in situ.
Positive_regulation (elevated) of growth-associated protein-43 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
6) Confidence 0.50 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1475048 Disease Relevance 0.45 Pain Relevance 0.57
Our results indicate that peripheral nerve injury induces novel synapse formation of A fibers in lamina II but that up-regulated levels of GAP-43 are present mainly in other axon projections to the superficial dorsal horn.
Positive_regulation (up-regulated) of GAP-43 in dorsal horn associated with nervous system injury, dorsal horn and peripheral nerve injury
7) Confidence 0.48 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9303528 Disease Relevance 0.31 Pain Relevance 0.48
When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity.
Positive_regulation (increases) of GAP-43 in neuronal associated with ganglion cysts and dorsal root ganglion
8) Confidence 0.47 Published 1990 Journal Neuroscience Section Abstract Doc Link 2139720 Disease Relevance 0.32 Pain Relevance 0.26
We used activating transcription factor 3 (ATF3) and growth-associated phosphoprotein (GAP-43) as markers for nerve injury and axonal regeneration, respectively.
Positive_regulation (activating) of GAP-43 in nerve associated with nervous system injury
9) Confidence 0.47 Published 2006 Journal Auton Neurosci Section Abstract Doc Link 16716760 Disease Relevance 0.50 Pain Relevance 0.35
Both vigorous neuritogenesis and elevated GAP-43 levels are characteristics of neurones that are actively regenerating following mechanical damage.
Positive_regulation (elevated) of GAP-43
10) Confidence 0.47 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1475048 Disease Relevance 0.44 Pain Relevance 0.57
RESULTS: In CP, GAP-43 was significantly increased in pancreatic nerve fibers and intrinsic neurons.
Positive_regulation (increased) of GAP-43 in intrinsic neurons
11) Confidence 0.45 Published 1997 Journal Gastroenterology Section Body Doc Link 9136844 Disease Relevance 0.18 Pain Relevance 0
Some of GAP-43 positive neurons in the ipsilateral DRG were also p-Erk+ (Fig. 6 D and H).
Positive_regulation (neurons) of GAP-43 in neurons
12) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.35 Pain Relevance 0.33
One week following a lesion of sciatic nerve in NSS treated DRG, the number of GAP-43+ and p-Erk+ neurons was significantly increased compared to those in the contralateral DRG (data not shown). p-Erk immunoreactivity was present in both nuclei and cytoplasm (Fig. 6 A and E).
Positive_regulation (increased) of GAP-43 in sciatic nerve associated with sciatic neuropathy and sciatic nerve
13) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.15 Pain Relevance 0.30
As it is known that sciatic nerve lesion causes upregulation of GAP-43 [75], [76] and phosphorylation of Erk [77], we sought to examine whether endogenous BDNF plays a role in the upregulation of GAP-43 and activated Erk, For this purpose, 8 rats were subjected to the sciatic nerve lesion and 4 rats were treated i.p with either normal sheep serum or the BDNF antiserum as described above.
Positive_regulation (upregulation) of GAP-43 in sciatic nerve associated with sciatic nerve and bdmf
14) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.44 Pain Relevance 0.42
As it is known that sciatic nerve lesion causes upregulation of GAP-43 [75], [76] and phosphorylation of Erk [77], we sought to examine whether endogenous BDNF plays a role in the upregulation of GAP-43 and activated Erk, For this purpose, 8 rats were subjected to the sciatic nerve lesion and 4 rats were treated i.p with either normal sheep serum or the BDNF antiserum as described above.
Positive_regulation (activated) of GAP-43 in sciatic nerve associated with sciatic nerve and bdmf
15) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.38 Pain Relevance 0.41
As it is known that sciatic nerve lesion causes upregulation of GAP-43 [75], [76] and phosphorylation of Erk [77], we sought to examine whether endogenous BDNF plays a role in the upregulation of GAP-43 and activated Erk, For this purpose, 8 rats were subjected to the sciatic nerve lesion and 4 rats were treated i.p with either normal sheep serum or the BDNF antiserum as described above.
Spec (whether) Positive_regulation (upregulation) of GAP-43 in sciatic nerve associated with sciatic nerve and bdmf
16) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.38 Pain Relevance 0.41
Others have also reported a parallel increase in a regenerative response post-axotomy, such as an upregulation of Gap43 and an up-regulation of genes involved in apoptosis, usually when axotomy is close to the cell body, and where most axotomized neurons subsequently undergo cell death [65-67].
Positive_regulation (upregulation) of Gap43 in neurons associated with apoptosis and death
17) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 1.15 Pain Relevance 0.05
HFES of sympathetic neurons induced a frequency dependent NGF and NT-3 gene and protein up-regulation (relative NGF protein expression: 0Hz=1+/-0.0 vs. 5Hz=1.13+/-0.19 vs. 50Hz=1.77+/-0.08, all n=5, 0Hz/5Hz vs. 50Hz p<0.05), with a subsequent increase of growth associated protein 43 (GAP-43) expression and morphological SNS.
Positive_regulation (increase) of GAP-43 in neurons associated with nerve growth factor
18) Confidence 0.34 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.30 Pain Relevance 0.49
HFES of sympathetic neurons induced a frequency dependent NGF and NT-3 gene and protein up-regulation (relative NGF protein expression: 0Hz=1+/-0.0 vs. 5Hz=1.13+/-0.19 vs. 50Hz=1.77+/-0.08, all n=5, 0Hz/5Hz vs. 50Hz p<0.05), with a subsequent increase of growth associated protein 43 (GAP-43) expression and morphological SNS.
Positive_regulation (increase) of associated protein 43 in neurons associated with nerve growth factor
19) Confidence 0.30 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.29 Pain Relevance 0.49
As well, expression of mRNAs for the neurotrophins NGF, BDNF, and NT-3 was examined. p75, trkA, and GAP-43 mRNAs were upregulated in DRGs from the NGF-treated, but not the control animals.
Positive_regulation (upregulated) of GAP-43 in DRGs
20) Confidence 0.27 Published 1998 Journal Exp. Neurol. Section Abstract Doc Link 9582251 Disease Relevance 0.15 Pain Relevance 0

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