INT102429

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 26
Disease Relevance 20.09
Pain Relevance 28.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 12
SAN 4
dorsal horn 4
muscle 2
nociceptors 2
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 729 100.00 Very High Very High Very High
dorsal root ganglion 231 100.00 Very High Very High Very High
nav1.3 116 100.00 Very High Very High Very High
Nav1.1 34 100.00 Very High Very High Very High
Nav1.6 30 100.00 Very High Very High Very High
Nav1.9 27 100.00 Very High Very High Very High
tetrodotoxin 85 99.98 Very High Very High Very High
sodium channel 132 99.92 Very High Very High Very High
Cancer pain 268 99.84 Very High Very High Very High
Sciatic nerve 25 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 335 100.00 Very High Very High Very High
Ganglion Cysts 233 100.00 Very High Very High Very High
Neuroma 79 100.00 Very High Very High Very High
Injury 175 99.96 Very High Very High Very High
Cancer Pain 196 99.84 Very High Very High Very High
Neuropathic Pain 116 99.44 Very High Very High Very High
Myocardial Infarction 14 99.36 Very High Very High Very High
Nociception 75 98.80 Very High Very High Very High
Nervous System Injury 59 98.66 Very High Very High Very High
Heart Rate Under Development 36 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, Nav1.1 and Nav1.6 are the dominant subunits in rat SAN, and downregulation of Nav1.1 and Nav1.6 expression contributes to HF-induced SAN dysfunction.
Negative_regulation (downregulation) of Gene_expression (expression) of Nav1 in SAN associated with nav1.1, nav1.6 and myocardial infarction
1) Confidence 0.59 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.55 Pain Relevance 1.70
After administration of antisense ODNs against Nav1.8, Nav1.8 protein expression decreased significantly and tumor-bearing rats showed alleviated mechanical hyperalgesia and ambulatory-evoked pain.
Negative_regulation (decreased) of Gene_expression (expression) of Nav1
2) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link 20482896 Disease Relevance 0 Pain Relevance 0
Western-blot showed that the total expression of Nav1.8 protein significantly decreased bilaterally in DRG of tumor-bearing rats.
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 in DRG
3) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link 20482896 Disease Relevance 0.05 Pain Relevance 0
We have previously demonstrated that Nav1.3 contributes directly to hyperresponsiveness of second-order dorsal horn neurons after CCI [9], and that knock-down of Nav1.3 expression with intrathecally-delivered antisense oligonucleotides that selectively target Nav1.3 mRNA can reduce Nav1.3 expression in NK1R-positive dorsal horn nociceptive neurons, quiet hyperresponsive dorsal horn neurons, and return behavioral nociceptive thresholds to near-normal levels.
Negative_regulation (reduce) of Gene_expression (expression) of Nav1 in dorsal horn associated with nociception, targeted disruption, nav1.3, eae, dorsal horn and dorsal horn neuron
4) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 1.00 Pain Relevance 1.46
The resulting data confirm that Nav1.8 expression in DRG can be significantly downregulated by antisense ODN treatment.
Negative_regulation (downregulated) of Gene_expression (expression) of Nav1 associated with dorsal root ganglion and nav1.8
5) Confidence 0.59 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.06 Pain Relevance 1.75
The expression of Nav1.8 and Nav1.9 protein was abolished in all injured DRG neurons, in all models.
Negative_regulation (abolished) of Gene_expression (expression) of Nav1 in neurons associated with dorsal root ganglion, nav1.8 and nav1.9
6) Confidence 0.59 Published 2002 Journal Pain Section Abstract Doc Link 11972999 Disease Relevance 0.96 Pain Relevance 1.53
Intrathecal administration of antisense oligodeoxynucleotides (ODNs) targeting Nav1.3 resulted in decreased expression of Nav1.3 mRNA and protein, reduced hyperexcitability of multireceptive dorsal horn neurons, and attenuated mechanical allodynia and thermal hyperalgesia after SCI.
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 in dorsal horn associated with nav1.3, allodynia, thermal hyperalgesia, frailty, dorsal horn neuron, hyperexcitability and intrathecal
7) Confidence 0.58 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14523090 Disease Relevance 1.59 Pain Relevance 1.99
Thus, although NaV1.3 is up-regulated in a subpopulation of DRG neurons after injury, reduction in the expression of NaV1.3 subtype alone is not sufficient to influence the NaV1-dependent behavioral hypersensitivity associated with nerve injury.
Negative_regulation (reduction) of Gene_expression (expression) of NaV1 in neurons associated with nervous system injury, hypersensitivity and injury
8) Confidence 0.43 Published 2005 Journal Pain Section Abstract Doc Link 16061326 Disease Relevance 0.86 Pain Relevance 0.34
Tumor-induced injury of sensory nerve fibers has been observed in ipsilateral DRG of tumor-bearing mice [31], suggesting that afferent nerve injury in a manner mimicking neuropathic pain is a probable cause of the decreased ipsilateral expression of Nav1.8.
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 in nerve associated with dorsal root ganglion, nervous system injury, cancer, injury, neuropathic pain and nav1.8
9) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.87 Pain Relevance 2.07
Moreover, a post hoc test revealed that Nav1.8 protein expression on the ipsilateral side of tumor-bearing rats was significantly downregulated (P < 0.05) compared with the contralateral side.
Negative_regulation (downregulated) of Gene_expression (expression) of Nav1 associated with cancer and nav1.8
10) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.14 Pain Relevance 1.34
Western-blot showed that the total expression of Nav1.8 protein significantly decreased bilaterally in DRG of tumor-bearing rats.
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 associated with cancer and nav1.8
11) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2894792 Disease Relevance 1.45 Pain Relevance 1.68
After administration of antisense ODNs against Nav1.8, Nav1.8 protein expression decreased significantly and tumor-bearing rats showed alleviated mechanical hyperalgesia and ambulatory-evoked pain.


Negative_regulation (decreased) of Gene_expression (expression) of Nav1 associated with pain, hyperalgesia, cancer and nav1.8
12) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2894792 Disease Relevance 1.27 Pain Relevance 1.50
In conclusion, Nav1.1 and Nav1.6 are the dominant subunits in rat SAN, and downregulation of Nav1.1 and Nav1.6 expression contributes to HF-induced SAN dysfunction.
Negative_regulation (downregulation) of Gene_expression (expression) of Nav1 in SAN associated with nav1.1, nav1.6 and myocardial infarction
13) Confidence 0.43 Published 2007 Journal Pflugers Arch. Section Abstract Doc Link 17273863 Disease Relevance 0.55 Pain Relevance 1.70
The factors that drive expression of Nav1.3 in these neurons are not yet clear, and a number of possibilities exist.
Negative_regulation (drive) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3
14) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.55 Pain Relevance 1.23
The expression of Nav1.8 in DRGs decreased in cancer pain rats, which is similar to those in neuropathic models[11,13,14].
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 associated with cancer pain, neuropathic pain and nav1.8
15) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.09 Pain Relevance 1.66
The expression of Nav1.8 and Nav1.9 protein was abolished in all injured DRG neurons, in all models.
Negative_regulation (abolished) of Gene_expression (expression) of Nav1 in neurons associated with dorsal root ganglion, nav1.8 and nav1.9
16) Confidence 0.43 Published 2002 Journal Pain Section Abstract Doc Link 11972999 Disease Relevance 0.96 Pain Relevance 1.53
This response reflects a genuine effect on TTX-sensitive Nav channels, as proven by its specific inhibition by TTX (EC50?
Negative_regulation (sensitive) of Gene_expression (channels) of Nav associated with tetrodotoxin
17) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.47
These findings suggest that in Aalpha/beta nociceptors, influences of NGF on expression levels of Nav1.8 are related to, and perhaps limited by, expression levels of trkA.
Negative_regulation (limited) of Gene_expression (expression) of Nav1 in nociceptors associated with nav1.8 and beta nociceptor
18) Confidence 0.40 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15888662 Disease Relevance 0.20 Pain Relevance 1.47
Downregulated Nav1.8 expression was observed in DRG neurons in a cancer pain model induced by inoculation with Walker 256 breast carcinosarcoma cells.
Negative_regulation (Downregulated) of Gene_expression (expression) of Nav1 in neurons associated with dorsal root ganglion, carcinosarcoma, cancer pain and nav1.8
19) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.69 Pain Relevance 1.45
Peripheral axotomy results in a decrease in the expression of functional Nav1.8 channels and TTX-R currents in C-type DRG neurons, suggesting a basis for the altered electrical properties observed after peripheral nerve injury [13].
Negative_regulation (decrease) of Gene_expression (expression) of Nav1 in neurons associated with dorsal root ganglion, tetrodotoxin, nervous system injury, nav1.8 and peripheral nerve injury
20) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.07 Pain Relevance 2.42

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