INT102449

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.85
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
plasma 1
muscle 1
cortex 1
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 27 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 99.36 Very High Very High Very High
Chronic pancreatitis 3 98.36 Very High Very High Very High
chemokine 14 92.68 High High
Osteoarthritis 81 92.28 High High
rheumatoid arthritis 225 91.36 High High
Neuropeptide 17 90.00 High High
Glutamate receptor 6 77.20 Quite High
cytokine 3 77.20 Quite High
Glutamate 2 73.12 Quite High
Disease Link Frequency Relevance Heat
Loss Of Sense Of Smell 112 100.00 Very High Very High Very High
Adenocarcinoma 6 99.28 Very High Very High Very High
Pancreatitis 3 98.36 Very High Very High Very High
Adhesions 236 96.88 Very High Very High Very High
Osteoarthritis 81 92.28 High High
Rheumatoid Arthritis 225 91.36 High High
Pancreatic Cancer 7 90.28 High High
Pheochromocytoma 3 84.12 Quite High
Hypoxia 3 76.80 Quite High
Paralysis 12 76.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In FLSs, adrenomedullin binds to a heterodimeric plasma membrane receptor composed of the seven-transmembrane domain protein calcitonin receptor-like receptor (CLR) coupled to one of two receptor activity-modifying proteins (RAMP-2 or -3) [9].
adrenomedullin Binding (binds) of in plasma
1) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.87 Pain Relevance 0.35
1 immunoblotting to investigate the interaction of the two proteins with adrenomedullin.
adrenomedullin Binding (interaction) of
2) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.82 Pain Relevance 0.10
CRLR combined with RAMP binds calcitonin gene-related peptide with high affinity, whereas CRLR coexpression with RAMP2 or -3 confers high-affinity binding of adrenomedullin.
adrenomedullin Binding (binding) of associated with calcitonin gene-related peptide
3) Confidence 0.30 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.24
At a cut-off level of 30.6 ng/ml, the specificity of ADM to differentiate PDAC from controls and CP patients was 85.5 and 83.6%, with a sensitivity of 80 and 100%.
ADM Binding (specificity) of associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.29 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.45 Pain Relevance 0.29
We tested interactions with the adrenomedullin receptor antagonist (22-52)adrenomedullin and with the protein kinase A (PKA) inhibitor H-89, and inhibition of co-receptor RAMP-2 by siRNA.
adrenomedullin Binding (interactions) of associated with antagonist
5) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991025 Disease Relevance 1.14 Pain Relevance 0.36
Five FDI and five ADM MEPs were averaged for each condition, and peak-to-peak maximal amplitude was calculated off-line.
ADM Binding (averaged) of
6) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253499 Disease Relevance 0.07 Pain Relevance 0.04
In fact, in the ADM muscle a slighter effect of both Smell and Obs was observed, without any interaction between them.
ADM Binding (interaction) of in muscle associated with loss of sense of smell
7) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253499 Disease Relevance 1.04 Pain Relevance 0
QPCR was performed based on the manufacturer's instructions with TaqMan Gene Expression Assays (Applied Biosystems) for the following genes: EGR3, SYNPO2, ANGPT2, SPP1, FOXM1, ADM, RDX, TGFBRAP1, MAK and EGR1(assay IDs: Hs00231780_m1, Hs00326493_m1, Hs01048047_mH, Hs00959010_m1, Hs00153543_m1, Hs00969450_g1, Hs00988414_g1; Hs01093285_m1; Hs01048300_m1, Hs00152928_m1).
ADM Binding (instructions) of
8) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.32 Pain Relevance 0
Coexpression of different RAMPs results in binding of different cyclic peptide ligands such as adrenomedullin, amylin or the calcitonin gene-related peptide (for a review see [60]).
adrenomedullin Binding (binding) of associated with calcitonin gene-related peptide
9) Confidence 0.16 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0.06 Pain Relevance 0.22
Adrenomedullin has now been shown to bind a family-B receptor and is discussed further below.
Adrenomedullin Binding (bind) of
10) Confidence 0.15 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.14
All conditions associated with AM were associated with statistically significant moving wave-fronts, moving from one retinotopic site to the next and with a motion feedback (wave-front detection in methods, Fig. 3 and Table 2).
AM Binding (associated) of
11) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
Experiment 1, thus revealed that associated with AM, there was a 19/21 wave-front, a motion feedback to 17/18, and a 17/18 wave-front moving in the direction of AM.
AM Binding (associated) of
12) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
V(t) increases in the shapes of wave-fronts in amplitude plots of the cortex were associated with all conditions of AM.
AM Binding (associated) of in cortex
13) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
In experiments 1, 2, and 3, the wave-fronts associated with AM moved in the opposite direction to the initial laterally spreading depolarization caused by the onset of the next square (Figs 4–7).
AM Binding (associated) of
14) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0.08 Pain Relevance 0

General Comments

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