INT102451

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
vasculature 3
brain 1
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 113 100.00 Very High Very High Very High
Neuropeptide 13 99.30 Very High Very High Very High
agonist 24 99.22 Very High Very High Very High
qutenza 8 98.90 Very High Very High Very High
antagonist 20 98.44 Very High Very High Very High
Calcitonin gene-related peptide 19 97.44 Very High Very High Very High
Glutamate receptor 2 93.84 High High
Gabapentin 10 92.52 High High
chemokine 2 91.44 High High
gABA 8 87.64 High High
Disease Link Frequency Relevance Heat
Syndrome 22 50.00 Quite Low
Cocaine Dependence 1 44.12 Quite Low
Neuropathic Pain 1 40.48 Quite Low
Anxiety Disorder 5 39.64 Quite Low
Convulsion 1 39.28 Quite Low
Adverse Drug Reaction 1 27.28 Quite Low
Suicidal Behaviour 2 21.12 Low Low
Depression 4 20.08 Low Low
Fatigue 2 15.92 Low Low
Affective Disorder 2 13.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.
Localization (localization) of receptor in vasculature
1) Confidence 0.69 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.21
Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.
Localization (localization) of receptor in vasculature
2) Confidence 0.61 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.21
Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.
Localization (localization) of receptor in vasculature
3) Confidence 0.61 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Title Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.21
The tachykinin NK2 receptor-mediated secretion was inhibited by i.c.v. injections of antagonists of the CGRP1 receptor (human CGRP fragment 8-37, 15 nmol) and non-N-methyl-D-aspartate (non-NMDA)-type glutamate receptor (6-cyano-7-nitroquinoxaline-2,3-dione, 10.9 nmol); the values were 30.8+/-29.8 and 5.7+/-16.9 microEq HCl, respectively.
Localization (secretion) of receptor associated with glutamate receptor, antagonist and calcitonin gene-related peptide
4) Confidence 0.01 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14985054 Disease Relevance 0 Pain Relevance 0.61
Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain.
Localization (secretion) of receptor in brain associated with qutenza and neuropeptide
5) Confidence 0.01 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 14985054 Disease Relevance 0 Pain Relevance 0.53
Other than a few scientific groups that suggest serotonergic/dopaminergic agonist therapy [33], most strategies embrace dopaminergic receptor blockade/attenuation of dopamine release [2,3,18-21].
Localization (release) of dopaminergic receptor associated with dopamine and agonist
6) Confidence 0.01 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0 Pain Relevance 1.11
For the same reason, we removed two singleton targets (targets that are the only member in a subfamily), the gonadotrophin-releasing hormone receptor and the ghrelin receptor.
Localization (releasing) of receptor
7) Confidence 0.01 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2897831 Disease Relevance 0 Pain Relevance 0.15
For the same reason, we removed two singleton targets (targets that are the only member in a subfamily), the gonadotrophin-releasing hormone receptor and the ghrelin receptor.
Localization (releasing) of receptor
8) Confidence 0.01 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2897831 Disease Relevance 0 Pain Relevance 0.15
Figure (1k and 1l) show intracellular localization of receptor pairs expressing a receptor mutated in the FX(6)LL motif.
Localization (localization) of receptor
9) Confidence 0.01 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox