INT102452

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.11
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (RAMP2) signal transduction (RAMP2) plasma membrane (RAMP2)
lysosome (RAMP2) cytoplasm (RAMP2)
RAMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 225 100.00 Very High Very High Very High
Calcitonin gene-related peptide 79 100.00 Very High Very High Very High
Osteoarthritis 81 98.96 Very High Very High Very High
Chronic pancreatitis 6 95.56 Very High Very High Very High
Inflammation 8 91.20 High High
antagonist 37 90.72 High High
Neuropeptide 9 87.88 High High
trigeminal ganglion 13 84.40 Quite High
Migraine 44 83.88 Quite High
medulla 2 83.08 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 225 100.00 Very High Very High Very High
Pancreatic Cancer 14 99.84 Very High Very High Very High
Osteoarthritis 81 98.96 Very High Very High Very High
Adhesions 225 98.48 Very High Very High Very High
Adenocarcinoma 12 96.24 Very High Very High Very High
Pancreatitis 6 95.56 Very High Very High Very High
Systemic Sclerosis 3 92.48 High High
Hypoxia 6 92.00 High High
Systemic Lupus Erythematosus 3 91.84 High High
Disease 6 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All 5 evaluated pancreatic cancer cells lines expressed ADM, CRLR, RAMP1 and RAMP2, whereas RAMP3 was expressed in only 1/5 pancreatic cancer cell lines.
Gene_expression (expressed) of RAMP2 associated with pancreatic cancer
1) Confidence 0.69 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.62 Pain Relevance 0.27
By immunohistochemistry, ADM, CRLR, RAMP1 and RAMP2, but not RAMP3, were expressed in pancreatic cancer cells.
Gene_expression (expressed) of RAMP2 associated with pancreatic cancer
2) Confidence 0.69 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.13 Pain Relevance 0.25
CRLR combined with RAMP binds calcitonin gene-related peptide with high affinity, whereas CRLR coexpression with RAMP2 or -3 confers high-affinity binding of adrenomedullin.
Gene_expression (coexpression) of RAMP2 associated with calcitonin gene-related peptide
3) Confidence 0.68 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.21
The association of CL with RAMP1 produces a CGRP receptor, with RAMP2 an AM receptor and with RAMP3 a CGRP/AM receptor.
Gene_expression (produces) of RAMP2 associated with calcitonin gene-related peptide
4) Confidence 0.58 Published 2004 Journal Physiol. Rev. Section Abstract Doc Link 15269340 Disease Relevance 0.17 Pain Relevance 0.65
Co-expression of CLR with RAMP1 composes the CGRP receptor, while co-expression of CLR with either RAMP2 or RAMP3 represents the adrenomedullin (AM) receptor or possibly a combined receptor (CGRP and AM).
Gene_expression (expression) of RAMP2 associated with calcitonin gene-related peptide
5) Confidence 0.47 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.59 Pain Relevance 1.17
To silence RAMP-2 expression in RA-FLS, an siRNA, ID number SASI_Hs01_00149404 [EBI:NM_005854], was used.
Gene_expression (expression) of RAMP-2 associated with rheumatoid arthritis
6) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.35 Pain Relevance 0.09
More recently, our group reported overexpression in RA-FLSs of adrenomedullin and its CLR/RAMP-2,3 receptor mRNA and protein, compared with FLSs from OA patients (OA-FLS) [10].
Gene_expression (overexpression) of RAMP-2 associated with rheumatoid arthritis and osteoarthritis
7) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.51 Pain Relevance 0.58
Given previous evidence that RA-FLSs expressed more adrenomedullin and adrenomedullin receptors (CLR/RAMP-2 and CLR/RAMP-3) than did OA-FLS [10], we compared the effect of adrenomedullin on RA-FLSs and OA-FLSs.
Gene_expression (expressed) of RAMP-2 associated with rheumatoid arthritis and osteoarthritis
8) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.74 Pain Relevance 0.53

General Comments

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