INT10248

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2011
Negated 67
Speculated 6
Reported most in Abstract
Documents 436
Total Number 442
Disease Relevance 231.96
Pain Relevance 32.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
B-cell 42
plasma 11
blood 11
body 7
T-cell 7
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 986 100.00 Very High Very High Very High
Paracetamol 36 100.00 Very High Very High Very High
Delta opioid receptors 6 100.00 Very High Very High Very High
potassium channel 174 99.84 Very High Very High Very High
Nav1.7 156 99.80 Very High Very High Very High
antagonist 224 99.60 Very High Very High Very High
Osteoarthritis 44 99.54 Very High Very High Very High
cytokine 494 99.52 Very High Very High Very High
tetrodotoxin 276 99.00 Very High Very High Very High
Inflammation 1110 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 4443 100.00 Very High Very High Very High
Lymphatic System Cancer 2129 100.00 Very High Very High Very High
Colorectal Cancer 138 100.00 Very High Very High Very High
Diffuse Large B-cell Lymphoma 438 99.98 Very High Very High Very High
Follicular Lymphoma 327 99.98 Very High Very High Very High
Colon Cancer 125 99.98 Very High Very High Very High
Systemic Lupus Erythematosus 1715 99.96 Very High Very High Very High
Ovarian Cancer 46 99.96 Very High Very High Very High
Mantle-cell Lymphoma 304 99.94 Very High Very High Very High
Adenocarcinoma 1443 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biopsy revealed diffuse, large B-cell non-Hodgkin's lymphoma expressing CD20.
Gene_expression (expressing) of CD20 in B-cell associated with lymphatic system cancer
1) Confidence 0.78 Published 2006 Journal Clin. Rheumatol. Section Abstract Doc Link 16247586 Disease Relevance 1.04 Pain Relevance 0.30
Tissue samples from 24 patients with pancreatic cancer and from 41 patients with colorectal cancer were examined for CK 20 expression by Northern blot analysis, immunohistochemistry, and in situ hybridization.
Spec (examined) Gene_expression (expression) of CK 20 associated with colon cancer and pancreatic cancer
2) Confidence 0.77 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.10 Pain Relevance 0.05
Despite its widespread diagnostic use in colorectal cancer and occasional use in pancreatic cancer, little is known about the expression of CK 20 in these tumors in vivo.
Gene_expression (expression) of CK 20 associated with cancer, pancreatic cancer and colon cancer
3) Confidence 0.77 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 0.95 Pain Relevance 0
It is concluded that CK 20 is overexpressed in pancreatic cancer and that it can serve as an excellent marker for metastatic pancreatic cancer.
Gene_expression (overexpressed) of CK 20 associated with pancreatic cancer
4) Confidence 0.77 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.30 Pain Relevance 0.09
Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer.
Gene_expression (expression) of cytokeratin 20 associated with colon cancer
5) Confidence 0.77 Published 1999 Journal Clin. Cancer Res. Section Title Doc Link 10537351 Disease Relevance 0.91 Pain Relevance 0
Therefore, in the present study we characterized CK 20 expression in pancreatic and colorectal cancer by comparison with its expression in the normal pancreas and colon.
Gene_expression (expression) of CK 20 in colon associated with colon cancer
6) Confidence 0.77 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 0.99 Pain Relevance 0
CK 20 expression was observed in the cancer cells of both cancer types.
Gene_expression (expression) of CK 20 associated with cancer
7) Confidence 0.77 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.21 Pain Relevance 0.06
DIAGNOSIS: Chemoresistant diffuse large B-cell lymphoma, with gradual loss of CD20 antigen expression.
Gene_expression (expression) of CD20 in B-cell
8) Confidence 0.77 Published 2008 Journal Nature clinical practice. Oncology Section Body Doc Link 18797436 Disease Relevance 0.42 Pain Relevance 0
Rituximab targets the CD20 molecule, which is selectively expressed on B cells and depletes these cells [26].
Gene_expression (expressed) of CD20 in B cells
9) Confidence 0.75 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 1.03 Pain Relevance 0.39
An immunohistochemical panel showed the tissue to be cytokeratin 20 (CK-20) positive, cytokeratin 7 (CK-7) negative and villin negative, thus in keeping with a colorectal primary tumour.
Gene_expression (negative) of CK-20 associated with cancer
10) Confidence 0.75 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1716166 Disease Relevance 1.54 Pain Relevance 0.10
All three adenomas were CK7 positive and CK20 negative.
Neg (negative) Gene_expression (negative) of CK20 associated with adenoma
11) Confidence 0.70 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15043313 Disease Relevance 1.12 Pain Relevance 0.12
The lymphoma consisted of large cells and expressed the B cell marker, CD20.
Gene_expression (expressed) of CD20 in B cell associated with lymphatic system cancer
12) Confidence 0.68 Published 1992 Journal Acta Pathol. Jpn. Section Abstract Doc Link 1476062 Disease Relevance 1.17 Pain Relevance 0.14
These cells expressed CD19, CD20, HLA-DR antigens.
Gene_expression (expressed) of CD20
13) Confidence 0.67 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 2067086 Disease Relevance 0.73 Pain Relevance 0.06
In contrast, colon cancers underexpressed CK 20 mRNA by comparison with the respective controls.
Gene_expression (underexpressed) of CK 20 mRNA in colon associated with colon cancer
14) Confidence 0.67 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.28 Pain Relevance 0.08
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Gene_expression (activity) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
15) Confidence 0.66 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.46 Pain Relevance 0.09
Neither entity possesses cytokeratin 20 (CK 20), progesterone receptor (PR), Calretinin, carcinoembryonic antigen (CEA), gross cystic disease fluid protein (BRST-2), and thyroid transcription factor 1 (TTF1).
Neg (Neither) Gene_expression (possesses) of CK 20 in thyroid associated with disease
16) Confidence 0.65 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.43 Pain Relevance 0
An immunohistochemical panel showed the tissue to be cytokeratin 20 (CK-20) positive, cytokeratin 7 (CK-7) negative and villin negative, thus in keeping with a colorectal primary tumour.
Gene_expression (positive) of cytokeratin 20 associated with cancer
17) Confidence 0.65 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1716166 Disease Relevance 1.48 Pain Relevance 0.10
Tumor cells were negative for cytokeratin, CD45, CD20, CD3, CD30, CD68, CD35 and CD1a; Ki-67 was positive in about 15% of the cells.
Neg (negative) Gene_expression (negative) of CD20 associated with cancer
18) Confidence 0.65 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2556649 Disease Relevance 0.63 Pain Relevance 0
Classically, adenocarcinoma of the lung, breast ovary and omentum are CK7 positive and CK20 negative, while adenocarcinoma of colorectal origin tends to have the opposite (CK7 negative and CK20 positive) [4,15].
Neg (negative) Gene_expression (negative) of CK20 in ovary associated with adenocarcinoma
19) Confidence 0.64 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2092434 Disease Relevance 0.85 Pain Relevance 0
As found in the majority of cases, Reed-Stenberg cells with positive expressions of CD30 and/or CD15, and negative expressions of CD20, CD3 and CD4, corroborate the diagnosis (Table 2).
Gene_expression (expressions) of CD20
20) Confidence 0.64 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2886079 Disease Relevance 1.14 Pain Relevance 0

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