INT102485

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVM 2
microglia 2
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 77 100.00 Very High Very High Very High
medulla 15 100.00 Very High Very High Very High
glial activation 1 99.24 Very High Very High Very High
lidocaine 2 98.12 Very High Very High Very High
Pain 13 97.92 Very High Very High Very High
Glutamate 2 87.88 High High
Hyperalgesia 10 74.68 Quite High
Neuropathic pain 16 55.96 Quite High
5HT 15 53.84 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 53 99.70 Very High Very High Very High
Pain 15 97.92 Very High Very High Very High
Nociception 8 91.44 High High
Injury 4 78.52 Quite High
Hyperalgesia 11 74.68 Quite High
Hypersensitivity 7 70.56 Quite High
Neuropathic Pain 19 55.96 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 38.28 Quite Low
INFLAMMATION 9 17.68 Low Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some experiments, microinjection of lidocaine (0.5 microl of 4% solution) or the neurotoxin ibotenic acid (0.5 microl, 10 microg) into the RVM produced reversible or long-lasting, respectively, decreases in spontaneous activity and responses of spinal neurons to CRD.
Negative_regulation (decreases) of Gene_expression (produced) of RVM in RVM associated with medulla and lidocaine
1) Confidence 0.36 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11976363 Disease Relevance 0.17 Pain Relevance 0.53
In our study, 8 days post SNI surgery, pERK expression within the RVM was limited to neurons and no glial activation was seen. p38, another MAPK involved in the maintenance of pain states, was found in microglia in the RVM 3 h after carrageenan injection into the hindpaw [27].
Negative_regulation (limited) of Gene_expression (expression) of RVM in microglia associated with pain, nervous system injury, glial activation and rostral ventromedial medulla
2) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.28 Pain Relevance 0.84

General Comments

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