INT102508

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.02
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (B3galt6) Golgi apparatus (B3galt6)
Anatomy Link Frequency
nucleus accumbens 3
dorsal 2
DRN 2
amygdala 1
B3galt6 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 20 99.98 Very High Very High Very High
Locus ceruleus 16 99.96 Very High Very High Very High
addiction 8 99.96 Very High Very High Very High
opiate 12 99.74 Very High Very High Very High
amygdala 8 98.64 Very High Very High Very High
Raphe 4 98.40 Very High Very High Very High
Ventral tegmentum 12 98.36 Very High Very High Very High
Nucleus accumbens 8 98.12 Very High Very High Very High
Autonomic response 4 94.20 High High
mu opioid receptor 4 93.60 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 4 99.96 Very High Very High Very High
Targeted Disruption 4 92.52 High High
Morphine Dependence 4 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses.
Positive_regulation (increased) of Gene_expression (expression) of beta-gal in nucleus accumbens associated with nucleus accumbens, autonomic response, amygdala and withdrawal
1) Confidence 0.47 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.27 Pain Relevance 1.14
Consistent with our model of opiate dependence, beta-gal expression increased in the LC, but decreased in the lateral ventral tegmental area (VTA) and dorsal raphe nucleus (DRN).
Positive_regulation (increased) of Gene_expression (expression) of beta-gal in dorsal associated with ventral tegmentum, addiction, locus ceruleus, opiate and raphe
2) Confidence 0.34 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.28 Pain Relevance 1.10
In LC, beta-gal expression was induced predominantly in tyrosine hydroxylase-expressing cells, whereas in the VTA and DRN the majority of cells expressing beta-gal were nonmonoaminergic.
Positive_regulation (induced) of Gene_expression (expression) of beta-gal in DRN associated with ventral tegmentum and locus ceruleus
3) Confidence 0.31 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.21 Pain Relevance 1.27
In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses.
Positive_regulation (increased) of in amygdala Gene_expression (expression) of beta-gal in nucleus accumbens associated with nucleus accumbens, autonomic response, amygdala and withdrawal
4) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.27 Pain Relevance 1.14

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