INT102508

Context Info Confidence 0.47 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 4 Disease Relevance 1.02 Pain Relevance 4.64

transferase activity, transferring glycosyl groups (B3galt6) Golgi apparatus (B3galt6)

Anatomy Link Frequency nucleus accumbens 3 dorsal 2 DRN 2 amygdala 1 B3galt6 (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 20 99.98 Locus ceruleus 16 99.96 addiction 8 99.96 opiate 12 99.74 amygdala 8 98.64 Raphe 4 98.40 Ventral tegmentum 12 98.36 Nucleus accumbens 8 98.12 Autonomic response 4 94.20 mu opioid receptor 4 93.60

Disease Link Frequency Relevance Heat Opiate Addiction 4 99.96 Targeted Disruption 4 92.52 Morphine Dependence 4 91.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses.

Positive_regulation (increased) of Gene_expression (expression) of beta-gal in nucleus accumbens associated with nucleus accumbens, autonomic response, amygdala and withdrawal

1) Confidence 0.47 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.27 Pain Relevance 1.14

Consistent with our model of opiate dependence, beta-gal expression increased in the LC, but decreased in the lateral ventral tegmental area (VTA) and dorsal raphe nucleus (DRN).

Positive_regulation (increased) of Gene_expression (expression) of beta-gal in dorsal associated with ventral tegmentum, addiction, locus ceruleus, opiate and raphe

2) Confidence 0.34 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.28 Pain Relevance 1.10

In LC, beta-gal expression was induced predominantly in tyrosine hydroxylase-expressing cells, whereas in the VTA and DRN the majority of cells expressing beta-gal were nonmonoaminergic.

Positive_regulation (induced) of Gene_expression (expression) of beta-gal in DRN associated with ventral tegmentum and locus ceruleus

3) Confidence 0.31 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.21 Pain Relevance 1.27

In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses.

Positive_regulation (increased) of in amygdala Gene_expression (expression) of beta-gal in nucleus accumbens associated with nucleus accumbens, autonomic response, amygdala and withdrawal

4) Confidence 0.16 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.27 Pain Relevance 1.14

General Comments

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