INT102510

Context Info Confidence 0.29 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.58 Pain Relevance 2.11

transferase activity, transferring glycosyl groups (B3galt6) Golgi apparatus (B3galt6)

Anatomy Link Frequency dorsal 2 B3galt6 (Mus musculus)

Pain Link Frequency Relevance Heat Locus ceruleus 8 100.00 addiction 4 99.96 opiate 6 99.74 Ventral tegmentum 6 99.36 withdrawal 10 98.72 Morphine 6 98.44 Raphe 2 97.76 amygdala 4 86.88 Nucleus accumbens 4 85.84 Autonomic response 2 78.00

Disease Link Frequency Relevance Heat Opiate Addiction 2 99.96 Targeted Disruption 2 99.12 Morphine Dependence 2 98.66

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Consistent with our model of opiate dependence, beta-gal expression increased in the LC, but decreased in the lateral ventral tegmental area (VTA) and dorsal raphe nucleus (DRN).

Negative_regulation (decreased) of Gene_expression (expression) of beta-gal in dorsal associated with ventral tegmentum, addiction, locus ceruleus, opiate and raphe

1) Confidence 0.29 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.28 Pain Relevance 1.11

To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and performed a regional and cellular mapping of beta-galactosidase (beta-gal) expression during naltrexone-precipitated withdrawal.

Negative_regulation (mapping) of Gene_expression (expression) of beta-gal associated with targeted disruption, addiction, withdrawal and morphine

2) Confidence 0.29 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.29 Pain Relevance 1.00

General Comments

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