INT102510

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Context Info
Confidence 0.29
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (B3galt6) Golgi apparatus (B3galt6)
Anatomy Link Frequency
dorsal 2
B3galt6 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 8 100.00 Very High Very High Very High
addiction 4 99.96 Very High Very High Very High
opiate 6 99.74 Very High Very High Very High
Ventral tegmentum 6 99.36 Very High Very High Very High
withdrawal 10 98.72 Very High Very High Very High
Morphine 6 98.44 Very High Very High Very High
Raphe 2 97.76 Very High Very High Very High
amygdala 4 86.88 High High
Nucleus accumbens 4 85.84 High High
Autonomic response 2 78.00 Quite High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 99.96 Very High Very High Very High
Targeted Disruption 2 99.12 Very High Very High Very High
Morphine Dependence 2 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our model of opiate dependence, beta-gal expression increased in the LC, but decreased in the lateral ventral tegmental area (VTA) and dorsal raphe nucleus (DRN).
Negative_regulation (decreased) of Gene_expression (expression) of beta-gal in dorsal associated with ventral tegmentum, addiction, locus ceruleus, opiate and raphe
1) Confidence 0.29 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.28 Pain Relevance 1.11
To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and performed a regional and cellular mapping of beta-galactosidase (beta-gal) expression during naltrexone-precipitated withdrawal.
Negative_regulation (mapping) of Gene_expression (expression) of beta-gal associated with targeted disruption, addiction, withdrawal and morphine
2) Confidence 0.29 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.29 Pain Relevance 1.00

General Comments

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