INT102512

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.01
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (B3galt6) Golgi apparatus (B3galt6)
Anatomy Link Frequency
nucleus accumbens 2
brain 2
DRN 2
dorsal 1
amygdala 1
B3galt6 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 28 99.96 Very High Very High Very High
addiction 15 99.96 Very High Very High Very High
Nucleus accumbens 14 99.96 Very High Very High Very High
withdrawal 35 99.78 Very High Very High Very High
opiate 21 99.74 Very High Very High Very High
Ventral tegmentum 21 99.38 Very High Very High Very High
amygdala 16 98.64 Very High Very High Very High
Raphe 7 98.00 Very High Very High Very High
Morphine 21 97.82 Very High Very High Very High
mu opioid receptor 7 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 7 99.96 Very High Very High Very High
Targeted Disruption 95 99.68 Very High Very High Very High
Cancer 217 98.56 Very High Very High Very High
Morphine Dependence 7 98.04 Very High Very High Very High
Volume Depletion And Dehydration 2 88.60 High High
Infection 1 63.20 Quite High
Overdose 4 52.28 Quite High
Renal Cancer 1 33.08 Quite Low
Melanoma 2 32.20 Quite Low
Cognitive Disorder 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our model of opiate dependence, beta-gal expression increased in the LC, but decreased in the lateral ventral tegmental area (VTA) and dorsal raphe nucleus (DRN).
Gene_expression (expression) of beta-gal in dorsal associated with ventral tegmentum, addiction, locus ceruleus, opiate and raphe
1) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.28 Pain Relevance 1.09
To determine whether these adaptations ultimately affect transcription mediated by the cAMP response element (CRE), we induced morphine dependence in CRE-LacZ transgenic mice and performed a regional and cellular mapping of beta-galactosidase (beta-gal) expression during naltrexone-precipitated withdrawal.
Gene_expression (expression) of beta-gal associated with targeted disruption, addiction, withdrawal and morphine
2) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.29 Pain Relevance 1.00
In nucleus accumbens, beta-gal was expressed in several major subpopulations of neurons.
Gene_expression (expressed) of beta-gal in nucleus accumbens associated with nucleus accumbens
3) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.22 Pain Relevance 1.27
In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses.
Gene_expression (expression) of beta-gal in nucleus accumbens associated with nucleus accumbens, autonomic response, amygdala and withdrawal
4) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.26 Pain Relevance 1.14
In LC, beta-gal expression was induced predominantly in tyrosine hydroxylase-expressing cells, whereas in the VTA and DRN the majority of cells expressing beta-gal were nonmonoaminergic.
Gene_expression (expression) of beta-gal in DRN associated with ventral tegmentum and locus ceruleus
5) Confidence 0.40 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.21 Pain Relevance 1.26
In LC, beta-gal expression was induced predominantly in tyrosine hydroxylase-expressing cells, whereas in the VTA and DRN the majority of cells expressing beta-gal were nonmonoaminergic.
Gene_expression (expressing) of beta-gal in DRN associated with ventral tegmentum and locus ceruleus
6) Confidence 0.40 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.19 Pain Relevance 1.19
In addition, withdrawal increased beta-gal expression in the continuum of the extended amygdala and nucleus accumbens, macrostructures associated with the coupling of emotional stimuli to motor and autonomic responses.
Gene_expression (expression) of beta-gal in amygdala associated with nucleus accumbens, autonomic response, amygdala and withdrawal
7) Confidence 0.18 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978842 Disease Relevance 0.26 Pain Relevance 1.14
Semiquantitative RT-PCR for PTPH1 and beta-gal gene expression was performed in different brain areas of PTPH1-KO and WT mice in order to confirm the presence of beta-gal expression in the KO tissues, replacing PTPH1 PDZ and catalytic domain.
Gene_expression (expression) of beta-gal in brain associated with targeted disruption
8) Confidence 0.09 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.38 Pain Relevance 0.09
Semiquantitative RT-PCR for PTPH1 and beta-gal gene expression was performed in different brain areas of PTPH1-KO and WT mice in order to confirm the presence of beta-gal expression in the KO tissues, replacing PTPH1 PDZ and catalytic domain.
Gene_expression (expression) of beta-gal in brain associated with targeted disruption
9) Confidence 0.08 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.42 Pain Relevance 0.08
Briefly to detect beta-gal expression non-treated CT26WT, CT26.CL25 and contralateral CT26.CL25 tumor samples that escaped PDT induced immunity were harvested when tumors reached 1.5 cm in diameter, fixed with Fix buffer (0.1 M phosphate buffer (pH 7.3) supplemented with 5 mM EGTA (Sigma), pH 7.3, 2 mM MgCl2 and 0.2% glutaraldahyde (Sigma)) for 15 min and washed twice (5 minutes each) with X-gal Wash buffer (0.1 M phosphate buffer (pH 7.3) supplemented with 2 mM MgCl2).
Gene_expression (expression) of beta-gal associated with cancer
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 0.50 Pain Relevance 0

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