INT102515

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 9.41
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
neuronal 2
pericytes 2
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 8 99.74 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.52 Very High Very High Very High
Inflammation 97 99.00 Very High Very High Very High
Bioavailability 17 98.80 Very High Very High Very High
agonist 50 97.88 Very High Very High Very High
ischemia 21 97.60 Very High Very High Very High
Angina 4 95.32 Very High Very High Very High
c fibre 10 95.28 Very High Very High Very High
cva 55 94.64 High High
Calcitonin gene-related peptide 6 94.56 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 17 99.24 Very High Very High Very High
INFLAMMATION 112 99.00 Very High Very High Very High
Increased Venous Pressure Under Development 263 98.92 Very High Very High Very High
Cv Unclassified Under Development 20 97.60 Very High Very High Very High
Myocardial Infarction 17 96.80 Very High Very High Very High
Diabetes Mellitus 93 96.08 Very High Very High Very High
Injury 10 95.76 Very High Very High Very High
Cv General 3 Under Development 10 95.32 Very High Very High Very High
Cardiovascular Disease 17 94.84 High High
Subarachnoid Hemorrhage 45 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coimmunoprecipitation demonstrated decreased association of Cav-1/eNOS in the IP group compared with the I/R group.
eNOS Binding (association) of
1) Confidence 0.45 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.40 Pain Relevance 0.28
Redox regulation of ischemic preconditioning is mediated by the differential activation of caveolins and their association with eNOS and GLUT-4.
eNOS Binding (association) of
2) Confidence 0.39 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 17277024 Disease Relevance 0.51 Pain Relevance 0.28
In all conditions, vascular endothelium showed scarce immunolabeling for endothelial nitric oxide synthase (eNOS); the profound immunoreactivity for eNOS, EpoR, and IL-3Rbeta was in pericytes.
endothelial nitric oxide synthase Binding (immunolabeling) of in pericytes
3) Confidence 0.35 Published 2010 Journal Angiology Section Abstract Doc Link 20547541 Disease Relevance 0.56 Pain Relevance 0.62
In all conditions, vascular endothelium showed scarce immunolabeling for endothelial nitric oxide synthase (eNOS); the profound immunoreactivity for eNOS, EpoR, and IL-3Rbeta was in pericytes.
eNOS Binding (immunolabeling) of in pericytes
4) Confidence 0.35 Published 2010 Journal Angiology Section Abstract Doc Link 20547541 Disease Relevance 0.56 Pain Relevance 0.62
Indirect immunohistochemical labelling was performed to reveal binding of primary antibodies against endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and TGF-beta.
eNOS Binding (binding) of
5) Confidence 0.34 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.26 Pain Relevance 0.07
CONCLUSIONS: This study provides evidence of an association between the NOS3 gene and subjects with glaucoma who have a history of migraine.
NOS3 gene Binding (association) of
6) Confidence 0.32 Published 2005 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 16123422 Disease Relevance 0 Pain Relevance 0
Western blot analysis was used for measurement of manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) in the mesenteric resistance arteries.
eNOS Binding (measurement) of
7) Confidence 0.31 Published 2004 Journal Acta Pharmacol. Sin. Section Body Doc Link 15569407 Disease Relevance 0.08 Pain Relevance 0
Indirect immunohistochemical labelling was performed to reveal binding of primary antibodies against endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and TGF-beta.
endothelial nitric oxide synthase Binding (binding) of
8) Confidence 0.30 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.26 Pain Relevance 0.07
In addition, diminished levels of the essential eNOS cofactor, tetrahydrobiopterin, results in uncoupling of eNOS and enhanced O2??
eNOS Binding (uncoupling) of associated with tetrahydrobiopterin
9) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.97 Pain Relevance 0.19
Another mechanism involves the uncoupling of eNOS as a result of diminished levels of the essential eNOS cofactor, tetrahydrobiopterin, resulting in enhanced O2??
eNOS Binding (uncoupling) of associated with tetrahydrobiopterin
10) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 0.55 Pain Relevance 0.16
Vascular relaxation is encountered by an activated endothelin (ET-1) system, and an over-activated ETA (endothelin receptor A) may contribute to a decline in eNOS activity, resulting in compromised NO bioavailability.1
eNOS Binding (activity) of associated with bioavailability
11) Confidence 0.21 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.73 Pain Relevance 0.05
CONCLUSIONS: As others have previously reported, we failed to demonstrate genetic association of the eNOS gene with migraine.


eNOS gene Binding (association) of
12) Confidence 0.19 Published 2008 Journal Headache Section Body Doc Link 18687083 Disease Relevance 0.06 Pain Relevance 0
iNOS is expressed following inflammatory or growth factor stimulation of cells unlike its counterpart eNOS (endothelial nitric oxide synthase) and nNOS (neuronal nitric oxide synthase) which are constitutively expressed.
endothelial nitric oxide synthase Binding (counterpart) of in neuronal associated with inflammation and neuronal nitric oxide synthase
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.16 Pain Relevance 0.21
iNOS is expressed following inflammatory or growth factor stimulation of cells unlike its counterpart eNOS (endothelial nitric oxide synthase) and nNOS (neuronal nitric oxide synthase) which are constitutively expressed.
eNOS Binding (counterpart) of in neuronal associated with inflammation and neuronal nitric oxide synthase
14) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.16 Pain Relevance 0.21
There is in vitro evidence that 5-methyltetrahydrofolate, the active form of folic acid, interacts with the enzyme endothelial nitric oxide synthase (eNOS) in a fashion analogous, yet independent, of the cofactor tetrahydrobiopterin to enhance endothelial function (Hyndman et al 2002).
eNOS Binding (interacts) of associated with tetrahydrobiopterin
15) Confidence 0.06 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993928 Disease Relevance 0.33 Pain Relevance 0.08
The results of our study suggest that folic acid, by directly interacting with eNOS, directly modulates NO production and endothelial function, independently of established markers of endothelial dysfunction and cardiovascular disease in type 2 diabetes.
eNOS Binding (interacting) of associated with diabetes mellitus and cardiovascular disease
16) Confidence 0.05 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993928 Disease Relevance 0.32 Pain Relevance 0.07
due to the ability of these chemicals to interfere with cNOS, but
cNOS Binding (interfere) of
17) Confidence 0.04 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 1.08 Pain Relevance 0.65
Also, certain endothelial NO synthase (eNOS) gene polymorphisms seem to be associated with an increased risk of vasospasm [30].
eNOS Binding (associated) of associated with increased venous pressure under development
18) Confidence 0.02 Published 2007 Journal Crit Care Section Body Doc Link PMC2206512 Disease Relevance 1.35 Pain Relevance 0.25
The eNOS4a allele was not associated with the severity of CAD (Fisher's exact test, p = 0.90) and the occurrence of acute myocardial infarction (AMI) or unstable angina (adjusted OR 0.6, 0.3-1.6) in patients with CAD.
eNOS4a Binding (associated) of associated with angina, coronary artery disease and myocardial infarction
19) Confidence 0.01 Published 2002 Journal Cardiology Section Abstract Doc Link 11978951 Disease Relevance 0.99 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox