INT102516

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 6.73
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
neuronal 6
neurons 4
spinal cords 2
plasma 1
neurite 1
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
TRP channel 247 100.00 Very High Very High Very High
Glutamate 23 100.00 Very High Very High Very High
Substantia nigra 5 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Glutamate receptor 6 99.28 Very High Very High Very High
ischemia 136 99.04 Very High Very High Very High
medulla 89 98.68 Very High Very High Very High
Pyramidal cell 74 98.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 36 99.52 Very High Very High Very High
Cv Unclassified Under Development 111 99.04 Very High Very High Very High
Necrosis 19 98.04 Very High Very High Very High
Carcinoma 2 97.92 Very High Very High Very High
Targeted Disruption 46 97.68 Very High Very High Very High
Ganglion Cysts 2 96.76 Very High Very High Very High
Injury 154 95.40 Very High Very High Very High
Drug Induced Neurotoxicity 24 91.56 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 38 90.00 High High
Neurodegenerative Disease 17 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both cell types formed neuritic networks and expressed the neuron-specific markers microtubule associated protein 2, synaptophysin, neurofilament and gamma-aminobutyric acid (GABA).
Gene_expression (expressed) of microtubule associated protein 2 in neuron associated with gaba
1) Confidence 0.69 Published 2003 Journal J. Neurosci. Methods Section Abstract Doc Link 12948560 Disease Relevance 0 Pain Relevance 0.30
Indeed, results suggest that MAP2 expression may be necessary for both neurite extension and cessation of cell division as the specific suppression of MAP2 synthesis prevents the neuronal differentiation of embryonic carcinoma cells exposed to retinoic acid, as shown by the absence of neurites [53].
Gene_expression (expression) of MAP2 in neuronal associated with carcinoma
2) Confidence 0.63 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.27 Pain Relevance 0.33
Indeed, results suggest that MAP2 expression may be necessary for both neurite extension and cessation of cell division as the specific suppression of MAP2 synthesis prevents the neuronal differentiation of embryonic carcinoma cells exposed to retinoic acid, as shown by the absence of neurites [53].
Gene_expression (synthesis) of MAP2 in neuronal associated with carcinoma
3) Confidence 0.63 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.31 Pain Relevance 0.41
We used a specific antibody to assess the expression of microtubule-associated protein 2 (MAP2), a major neuronal marker for dendritic processes, entwined with a second major neuronal marker (NeuN), that represents a nuclear protein specifically expressed in post-mitotic neurons.
Gene_expression (expression) of microtubule-associated protein 2 in neuronal
4) Confidence 0.58 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0.08
We used a specific antibody to assess the expression of microtubule-associated protein 2 (MAP2), a major neuronal marker for dendritic processes, entwined with a second major neuronal marker (NeuN), that represents a nuclear protein specifically expressed in post-mitotic neurons.
Gene_expression (expression) of MAP2 in neuronal
5) Confidence 0.58 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2871691 Disease Relevance 0 Pain Relevance 0.08
No ischemic lesion was detected by MAP2 staining (Figure 1C).
Neg (No) Gene_expression (detected) of MAP2
6) Confidence 0.52 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.43 Pain Relevance 0.35
We also demonstrated clusters of IBA-1-expressing cells in the ischemic lesions where MAP2 staining was lost three days after ischemia and thereafter.
Gene_expression (staining) of MAP2 associated with ischemia
7) Confidence 0.52 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.61 Pain Relevance 0.22
Rats were all killed after 8 weeks to evaluate the levels of neurofilament(NF)-L, NF-M, NF-H, beta-actin, alpha-tubulin, beta-tubulin, tau, MAP2 proteins in plasma using both SDS-PAGE and western blotting.
Gene_expression (levels) of MAP2 in plasma
8) Confidence 0.47 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.25 Pain Relevance 0.06
The type of neurite that has undergone sprouting with NCS1 overexpression was further investigated using the specific dendritic immunomarker microtubule-associated protein 2 (MAP2).
Spec (investigated) Gene_expression (using) of MAP2 in neurite
9) Confidence 0.46 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.46 Pain Relevance 0
Histology and MAP-2
Gene_expression (Histology) of MAP-2
10) Confidence 0.36 Published 2008 Journal Acta Radiologica (Stockholm, Sweden : 1987) Section Body Doc Link PMC2582156 Disease Relevance 0.36 Pain Relevance 0
The detection of MAP2, ankyrinG, GAD and Kv2.1 in cultured hippocampal neurons has been performed by multiple groups using either the same antibodies as used here or closely related ones [2,7,18,20,30-36].
Gene_expression (detection) of MAP2 in neurons associated with generalized anxiety disorder
11) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0.15 Pain Relevance 0
The cell treated with both siRNAs of TRPC5 and TRPC6 also showed decrease in TG-stimulated Ba2+ influx and did not express MAP2, but expressed Nestin (Figure 7C).
Neg (not) Gene_expression (express) of MAP2
12) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.15 Pain Relevance 0
In the differentiation condition, the cell treated with siRNA of TRPC5 showed decrease in TG-stimulated Ba2+ influx and did not express MAP2, but expressed Nestin (Figure 7A).
Neg (not) Gene_expression (express) of MAP2
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.13 Pain Relevance 0
An anti-microtubule associated protein 2 (MAP2) antibody (1:500, monoclonal, obtained from Boehringer Mannheim, Darmstadt, Germany) and an anti-A?
Gene_expression (antibody) of MAP2
14) Confidence 0.31 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515900 Disease Relevance 0 Pain Relevance 0
Neither the control cells nor the RacDN and RhoDN cells exhibited MAP2 expression in the host spinal cords.
Gene_expression (expression) of MAP2 in spinal cords
15) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.20 Pain Relevance 0.24
Neither control cells nor RacDN and RhoDN cells exhibited MAP2 expression in the host spinal cords.
Gene_expression (expression) of MAP2 in spinal cords
16) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.15 Pain Relevance 0
Kv2.1 localization in a single proximal neurite with diminished MAP2 staining, i.e. the AIS (marked by the arrow in Fig. 3), was observed in 35% of 7 DIV neurons and 63% of 10 DIV neurons (200 neurons examined in each of three experiments).
Gene_expression (staining) of MAP2 in neurons
17) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0 Pain Relevance 0.11
We observed Kv2.1 expression on MAP2-positive neurites in only 10% of the 7 DIV neurons and 2% of the day 10 and 14 cells.
Gene_expression (expression) of MAP2 in neurons
18) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0 Pain Relevance 0.06
This cell did not express Nestin, but expressed MAP2 (Figure 7B).
Gene_expression (expressed) of MAP2
19) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0.23 Pain Relevance 0
In addition, most of them were positive for MAP2, mature neural cell marker (Figure 1F); O4, oligodendrocyte marker (Figure 1H); or GFAP, astrocyte marker (Figure 1H).


Gene_expression (positive) of MAP2 in astrocyte
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox