INT102525

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 16.19
Pain Relevance 10.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR3) extracellular space (CCR3) cell adhesion (CCR3)
plasma membrane (CCR3) signal transducer activity (CCR3)
Anatomy Link Frequency
eosinophils 6
macrophage 3
blood 2
sputum 1
brain 1
CCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 396 100.00 Very High Very High Very High
rheumatoid arthritis 492 99.84 Very High Very High Very High
Morphine 26 99.58 Very High Very High Very High
Inflammation 456 99.40 Very High Very High Very High
Osteoarthritis 19 98.52 Very High Very High Very High
Opioid 28 98.20 Very High Very High Very High
opiate 9 93.52 High High
Codeine 1 92.40 High High
Pain 5 91.20 High High
Analgesic 3 90.28 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 130 100.00 Very High Very High Very High
Rheumatoid Arthritis 492 99.84 Very High Very High Very High
INFLAMMATION 479 99.40 Very High Very High Very High
Gastroesophageal Reflux Disease 72 98.96 Very High Very High Very High
Systemic Lupus Erythematosus 39 98.80 Very High Very High Very High
Anaplastic Astrocytoma 7 98.68 Very High Very High Very High
Osteoarthritis 23 98.52 Very High Very High Very High
Eosinophilia 71 98.08 Very High Very High Very High
Hookworm Infection 109 97.60 Very High Very High Very High
Toxicity 51 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein we describe the effects of morphine and/or gp120 on the expression of the genes for the beta-chemokine MIP-1beta and its receptors CCR3 and CCR5 by the U373 cells which are a human brain-derived astrocytoma/glioblastoma cell line.
Gene_expression (expression) of CCR3 in brain associated with anaplastic astrocytoma, chemokine, glioblastoma and morphine
1) Confidence 0.71 Published 2005 Journal Curr. HIV Res. Section Abstract Doc Link 16022659 Disease Relevance 1.44 Pain Relevance 0.92
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR.
Gene_expression (expression) of CCR3 in NHA associated with chemokine and morphine
2) Confidence 0.68 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.87
Treatment of NHAs with morphine suppressed IL-8 and macrophage-inflammatory protein-1beta gene expression, whereas expression of their receptor genes, CCR3 and CCR5, was simultaneously enhanced.
Gene_expression (expression) of CCR3 in macrophage associated with inflammation and morphine
3) Confidence 0.67 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 1.13 Pain Relevance 1.30
Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS.
Gene_expression (expression) of CCR3 in macrophage associated with chemokine, inflammation, encephalopathy, acquired immune deficiency syndrome or hiv infection, opioid and infection
4) Confidence 0.67 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 0.78 Pain Relevance 1.29
Furthermore, RA monocytes/macrophages express CC chemokine receptors such as CCR1, CCR2, CCR3 and CCR5 [14], illustrating their broad profile of chemokine receptor expression.
Gene_expression (express) of CCR3 in macrophages associated with chemokine and rheumatoid arthritis
5) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.93 Pain Relevance 0.69
Our results indicate that treatment of U373 cells with morphine significantly downregulated the gene expression of the beta chemokine, MIP-1 beta, while reciprocally upregulating the expression of its specific receptors, CCR3 and CCR5 suggesting that the capacity of mu-opioids to increase HIV-1 co-receptor expression may promote viral binding, trafficking of HIV-1-infected cells, and enhanced disease progression.
Gene_expression (expression) of CCR3 associated with chemokine, acquired immune deficiency syndrome or hiv infection, opioid, disease progression and morphine
6) Confidence 0.55 Published 2005 Journal Curr. HIV Res. Section Abstract Doc Link 16022659 Disease Relevance 1.40 Pain Relevance 0.97
Although the parasite has developed the ability to specifically cleave eotaxin, hypothetically inhibiting eosinophil recruitment [35], the upregulation of CCR3 expression may counterbalance this effect.
Gene_expression (expression) of CCR3 in eosinophil
7) Confidence 0.54 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.60 Pain Relevance 0.05
Moreover, we have demonstrated that activated eosinophils express relatively higher levels of the eotaxin receptor (CCR3), suggesting that these cells may be recruited to sites of inflammation.
Gene_expression (express) of CCR3 in eosinophils associated with inflammation
8) Confidence 0.54 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.55 Pain Relevance 0.05
Moreover, we have demonstrated that activated eosinophils express relatively higher levels of the eotaxin receptor (CCR3), suggesting that these cells may be recruited to sites of inflammation.
Gene_expression (express) of eotaxin receptor in eosinophils associated with inflammation
9) Confidence 0.54 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.55 Pain Relevance 0.05
Four chemokine receptors (CCR2b, CCR3, CCR4 and CCR6) could not be detected in RA samples or non-RA samples under our conditions.
Neg (not) Gene_expression (detected) of CCR3 associated with chemokine and rheumatoid arthritis
10) Confidence 0.47 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.17 Pain Relevance 0.71
The allergen-induced levels of beta-chain mRNA and CCR3 mRNA in sputum-derived cells were inhibited by TPIASM8, but no significant effects on cell surface protein expression of CCR3 and the beta-chain were found.
Gene_expression (expression) of CCR3 in sputum
11) Confidence 0.42 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.73 Pain Relevance 0.06
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Gene_expression (one) of CCR3 in 1C6
12) Confidence 0.38 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.09
Interestingly, expression of GATA-3, CCR3, -4, -8, and ST2L, and the generation of blood eosinophilia, is intact in mice doubly deficient in both IL-4 and IL-13 [304].
Gene_expression (expression) of CCR3 in blood associated with eosinophilia
13) Confidence 0.34 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.11
CCR3, the eotaxin-3 receptor, also had an increased expression factor of 2× compared to GERD and HC (Figure 1b).
Gene_expression (expression) of eotaxin-3 receptor associated with gastroesophageal reflux disease
14) Confidence 0.31 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.34 Pain Relevance 0
CCR3, the eotaxin-3 receptor, also had an increased expression factor of 2× compared to GERD and HC (Figure 1b).
Gene_expression (expression) of CCR3 associated with gastroesophageal reflux disease
15) Confidence 0.31 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.34 Pain Relevance 0
TPIASM8 is a new inhaled compound consisting of two modified RNA-targeting oligonucleotides directed against the CCR3 receptor, and the common ?
Gene_expression (directed) of CCR3 receptor
16) Confidence 0.29 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.48 Pain Relevance 0.18
Pretreatment of eosinophils with indomethacin also enhanced subsequent eosinophil shape change induced by eotaxin, although treatment with higher concentrations of indomethacin resulted in a decrease in the expression of the major eosinophil chemokine receptor, CCR3.
Gene_expression (expression) of CCR3 in eosinophils associated with chemokine
17) Confidence 0.28 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11980903 Disease Relevance 0.17 Pain Relevance 0.15
Blood PDCs express many different chemokine receptors including CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 [40], whereas MDC express CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8 [19], [20], [21].
Gene_expression (express) of CCR3 in Blood associated with chemokine
18) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.23 Pain Relevance 0.14
Pretreatment of eosinophils with indomethacin also enhanced subsequent eosinophil shape change induced by eotaxin, although treatment with higher concentrations of indomethacin resulted in a decrease in the expression of the major eosinophil chemokine receptor, CCR3.
Gene_expression (expression) of eosinophil chemokine receptor in eosinophils associated with chemokine
19) Confidence 0.25 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11980903 Disease Relevance 0.17 Pain Relevance 0.15
In vitro observations further suggest that eotaxin-3, produced by IL-4 stimulated airway epithelial cells, and eosinophil expression of CCR3 mediate transepithelial migration [19].
Gene_expression (expression) of CCR3 in eosinophil
20) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.09 Pain Relevance 0.12

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