INT102532

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Context Info
Confidence 0.64
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 16.78
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
cleavage 6
poly 2
apoptotic cells 1
EL4 1
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cryotherapy 17 97.92 Very High Very High Very High
imagery 52 96.72 Very High Very High Very High
Inflammation 22 93.76 High High
agonist 19 93.60 High High
chemokine 21 93.48 High High
anesthesia 4 92.60 High High
antagonist 2 89.08 High High
methotrexate 17 88.72 High High
palliative 10 76.48 Quite High
fortral 9 61.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 936 99.98 Very High Very High Very High
Apoptosis 788 99.84 Very High Very High Very High
Necrosis 25 99.20 Very High Very High Very High
Pancreatic Cancer 83 99.02 Very High Very High Very High
Death 138 98.56 Very High Very High Very High
Nerve Sheath Neoplasms 44 95.52 Very High Very High Very High
Ganglion Cysts 24 94.96 High High
INFLAMMATION 24 93.76 High High
Diabetes Mellitus 127 92.96 High High
Severe Combined Immunodeficiency 41 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Techniques to detect cell apoptosis included immunohistochemistry of cleaved caspase-3 and single-strand DNA, as well as electron microscopy.
Protein_catabolism (cleaved) of caspase-3 associated with apoptosis
1) Confidence 0.64 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18852026 Disease Relevance 0.33 Pain Relevance 0.09
The induction of apoptosis was analysed by immunohistochemical staining of cleaved caspase-3 and by TUNEL.
Protein_catabolism (cleaved) of caspase-3 associated with apoptosis
2) Confidence 0.64 Published 2005 Journal Cryobiology Section Abstract Doc Link 15710367 Disease Relevance 1.38 Pain Relevance 0.30
Two protocols of cryotherapy (1 vs 3 cycles of freezing) were performed and the induction of apoptosis was analyzed by immunohistochemical staining of cleaved caspase-3.
Spec (analyzed) Protein_catabolism (cleaved) of caspase-3
3) Confidence 0.64 Published 2005 Journal Pathol. Biol. Section Body Doc Link 15850952 Disease Relevance 0 Pain Relevance 0
Apoptosis was analysed by immunohistochemical staining of cleaved caspase-3 and by TUNEL.
Protein_catabolism (cleaved) of caspase-3 associated with apoptosis
4) Confidence 0.64 Published 2005 Journal Cryobiology Section Abstract Doc Link 15963488 Disease Relevance 1.06 Pain Relevance 0.20
To determine if this hypervascularization could enhance the efficiency of chemotherapy, the drug was injected 15 days after cryotherapy and the induction of cell death was investigated (morphological study, immunohistochemical staining of cleaved caspase-3, TUNEL).
Protein_catabolism (cleaved) of caspase-3 associated with cryotherapy and death
5) Confidence 0.64 Published 2006 Journal Lung Cancer Section Abstract Doc Link 16889870 Disease Relevance 0.87 Pain Relevance 0.19
Elevated cleaved caspase-3 was also validated semi-quantitatively by immunoblotting assay.
Protein_catabolism (cleaved) of caspase-3
6) Confidence 0.64 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18852026 Disease Relevance 0.38 Pain Relevance 0.09
The proapoptotic effect of rolipram was associated with decreased levels of the prosurvival protein Mcl-1 and increased caspase-3 cleavage.
Protein_catabolism (cleavage) of caspase-3 in cleavage
7) Confidence 0.64 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.76 Pain Relevance 0.31
Subsequently, the level of caspase-3-mediated cleavage of PARP-1 reached a maximum 96 hours post-chemotherapy, which is when ex vivo binding of DAB4 to dead EL4 cells was maximal.
Protein_catabolism (cleavage) of caspase-3-mediated in EL4
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.94 Pain Relevance 0
Immunohistochemical measurements of tumor caspase-3 activation and PARP-1 cleavage, which are indicators of early and late apoptosis, respectively, were correlated with tumor accumulation of DAB4.
Protein_catabolism (cleavage) of caspase-3 in cleavage associated with cancer and apoptosis
9) Confidence 0.35 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2645692 Disease Relevance 2.19 Pain Relevance 0.05
For each sample, three sections were analysed and averaged.To detect cleaved caspase-3, unstained sections were subjected to heat-induced antigen retrieval in a microwave oven for 5 min in 10 mmol/l citrate buffer, and the endogenous peroxidase was abolished by incubating the sections in 3% (wt/vol.) hydrogen peroxide in methanol for 10 min.
Protein_catabolism (cleaved) of caspase-3
10) Confidence 0.31 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.28 Pain Relevance 0
At day 3, during severe morphological damage, and day 7, during regeneration, expression of cleaved caspase-3 was comparable to control level.
Protein_catabolism (cleaved) of caspase-3
11) Confidence 0.24 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.49 Pain Relevance 0.07
Analysis of EC samples from Transwell revealed an increase in cleavage of caspase 3, concomitant with a decrease in the anti-apoptotic BCl-xL upon TGF-?
Protein_catabolism (cleavage) of caspase 3 in cleavage associated with apoptosis
12) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.56 Pain Relevance 0
In order to identify small molecules that mimic the neurotrophic activities of BDNF, we developed a cell-based apoptotic assay using a cell permeable fluorescent dye MR(DERD)2, which turns red upon caspase-3 cleavage in apoptotic cells.
Protein_catabolism (cleavage) of caspase-3 in apoptotic cells associated with apoptosis
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.70 Pain Relevance 0.13
Next, in order to further characterize this effect, we evaluated the growth phase of these pancreatic cancer cells under these conditions by co-staining for cleaved caspase-3 and the proliferation maker Ki-67.
Protein_catabolism (cleaved) of caspase-3 associated with pancreatic cancer
14) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.77 Pain Relevance 0.06
Fixed cells were resuspended in TUNEL reagent or cleaved caspase-3 antibody and incubated overnight at room temperature (TUNEL) or 4°C (Caspase 3).
Protein_catabolism (cleaved) of caspase-3
15) Confidence 0.16 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.34 Pain Relevance 0.06
Boston, MA) and incubated overnight at room temperature (TUNEL) or 4°C (cleaved caspase-3).
Protein_catabolism (cleaved) of caspase-3
16) Confidence 0.15 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 0.25 Pain Relevance 0.03
In addition, cleavage of caspase-3, a common downstream regulator of SAPK/JNK [23,34], was assayed.
Protein_catabolism (cleavage) of caspase-3 in cleavage
17) Confidence 0.11 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.43 Pain Relevance 0
The activation of these two caspases and cleaved PARP were determined by Western blot analysis using antibodies capable of detecting cleaved caspase-3, caspase-7 and PARP.
Protein_catabolism (cleaved) of caspase-3
18) Confidence 0.10 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.71 Pain Relevance 0
U0126 induced the release of cytochrome c and increased the cleavage of caspase-3, caspase-7, and poly ADP-ribose polymerase (PARP).
Protein_catabolism (cleavage) of caspase-3 in poly
19) Confidence 0.10 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.85 Pain Relevance 0
Because cleaved caspase-3 and -7 and PARP has been proposed as one of the events in the execution phase of apoptosis, the levels of cleaved caspase-3, -7 and PARP were used as markers for apoptosis.
Protein_catabolism (cleaved) of caspase-3 associated with apoptosis
20) Confidence 0.10 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.43 Pain Relevance 0

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