INT102545

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 14
Speculated 1
Reported most in Body
Documents 42
Total Number 113
Disease Relevance 61.43
Pain Relevance 19.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
monocytes 26
macrophages 10
T cells 9
brains 6
microglia 5
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2974 100.00 Very High Very High Very High
chemokine 2005 100.00 Very High Very High Very High
antagonist 303 100.00 Very High Very High Very High
Pain 126 100.00 Very High Very High Very High
allodynia 25 99.96 Very High Very High Very High
Peripheral nervous system 75 99.38 Very High Very High Very High
Central nervous system 1022 99.36 Very High Very High Very High
Multiple sclerosis 1197 99.16 Very High Very High Very High
Neuropathic pain 191 98.68 Very High Very High Very High
imagery 220 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3172 100.00 Very High Very High Very High
Influenza Virus Infection 82 100.00 Very High Very High Very High
Multiple Sclerosis 4680 99.98 Very High Very High Very High
Targeted Disruption 1172 99.96 Very High Very High Very High
Neuropathic Pain 219 99.96 Very High Very High Very High
Pain 150 99.84 Very High Very High Very High
Disease 1685 99.76 Very High Very High Very High
Demyelinating Disease 1348 99.16 Very High Very High Very High
Pulmonary Disease 522 99.16 Very High Very High Very High
Viral Meningitis 72 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings are consistent with recent reports that peripheral nervous system but not CNS neurons inducibly express CCR2 in pain models [32].


Neg (not) Gene_expression (express) of CCR2 in peripheral nervous system associated with pain and peripheral nervous system
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.27 Pain Relevance 0.20
Thus, our findings reveal that Ly6Clo/CX3CR1+ monocytes are relatively excluded from the inflamed CNS of mice with EAE, regardless of CCR2 expression.
Gene_expression (expression) of CCR2 in monocytes associated with multiple sclerosis
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.51 Pain Relevance 0.11
All CCR2-positive cells were RFP positive, but some RFP-positive cells failed to express CCR2 at the cell surface.


Neg (failed) Gene_expression (express) of CCR2
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.06 Pain Relevance 0
In contrast, microglia did not express CCR2 under naive conditions or EAE-associated inflammation.
Neg (not) Gene_expression (express) of CCR2 in microglia associated with multiple sclerosis and inflammation
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.29 Pain Relevance 0.05
For example, cell “1” in Fig. 6A is 7/4+, RFP+ and GFPdim, suggesting it is a Ly6Chi monocyte that expresses both CCR2 and CX3CR1.
Gene_expression (expresses) of CCR2 in monocyte
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.27 Pain Relevance 0.17
First, because some T cells and NK cells express CCR2 transcripts and are thus RFP-positive, it is not possible to conclude that all red cells in an image are monocytes.
Gene_expression (express) of CCR2 in monocytes
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.88 Pain Relevance 0.18
Additional signals might initiate CCR2 translation in these monocytes and thus provide the potential to rapidly upregulate CCR2 expression.
Gene_expression (expression) of CCR2 in monocytes
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.45 Pain Relevance 0.10
To visualize the distribution of cells expressing GFP (CX3CR1) and RFP (CCR2), free-floating sections were stained with 15 nM DAPI for 5 min, and whole-brain sections were scanned using a Leica DM5500B with motorized x,y stage.
Gene_expression (expressing) of CCR2 in brain
8) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.70 Pain Relevance 0.03
subsets [14] express chemokine receptor 2 (CCR2) and low levels of CX3CR1 [2] and appear to be functionally equivalent across species.
Gene_expression (express) of CCR2 associated with chemokine
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.23
Lack of CCR2RFP expression by neuroepithelial cells
Gene_expression (expression) of CCR2RFP in neuroepithelial cells
10) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.20 Pain Relevance 0
We showed that CCR2 expression is controlled at a post-transcriptional stage in some Ly6Clo monocytes and NK and T cells.
Gene_expression (expression) of CCR2 in T cells
11) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.10
While most but not all Ly6Clo monocytes were negative for CCR2 staining, some Ly6Clo monocytes expressed CCR2 at levels similar to those in Ly6Chi monocytes.
Gene_expression (expressed) of CCR2 in monocytes
12) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.20 Pain Relevance 0.03
RFP and CCR2 RNA expression in leukocytes
Gene_expression (expression) of CCR2 in leukocytes
13) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.06 Pain Relevance 0
In analyses of CNS tissues of CCR2-RFP mice, the location and morphology of CCR2-RFP cells provided no evidence of CCR2 expression by CNS neurons.
Gene_expression (expression) of CCR2 in neurons
14) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.25 Pain Relevance 0.18
Our EAE experiments revealed physiologically relevant and mechanistically intriguing functions of CCR2 expression and regulation of CNS myeloid inflammation.
Gene_expression (expression) of CCR2 associated with multiple sclerosis and inflammation
15) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 1.15 Pain Relevance 0.13
To visualize CX3CR1-and CCR2-expressing cells in the brains of Ccr2RFP/+Cx3cr1GFP/+ and Ccr2RFP/RFPCx3cr1GFP/+ mice, we used fluorescence microscopy.
Gene_expression (-) of CCR2 in brains
16) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.22 Pain Relevance 0
Nonetheless, the ability to simultaneously image CCR2 and CX3CR1 expression in monocytes and other leukocytes represents a powerful new tool for investigating complex pathophysiology.
Gene_expression (expression) of CCR2 in leukocytes
17) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.48 Pain Relevance 0.11
subsets [14] express chemokine receptor 2 (CCR2) and low levels of CX3CR1 [2] and appear to be functionally equivalent across species.
Gene_expression (express) of chemokine receptor 2 associated with chemokine
18) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.23
Flow cytometric analysis of Ccr2RFP/+ and Ccr2RFP/RFP peripheral blood cells stained for cell-surface CCR2 (Figure 1C) confirmed bi-allelic expression of CCR2 and RFP in heterozygous mice and deletion of CCR2 in Ccr2RFP/RFP homozygous mice.
Gene_expression (expression) of CCR2 in blood cells
19) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.18 Pain Relevance 0.03
Furthermore, CCR2-RFP expression did not overlap with markers of astrocytes, neurons, or oligodendrocytes (data not shown).
Gene_expression (expression) of CCR2 in astrocytes
20) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.28 Pain Relevance 0.14

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