INT102546

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 197
Total Number 199
Disease Relevance 192.80
Pain Relevance 67.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 36
macrophage 22
leukocyte 7
astrocytes 5
lung 5
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 5136 100.00 Very High Very High Very High
chemokine 3755 100.00 Very High Very High Very High
cytokine 1888 100.00 Very High Very High Very High
antagonist 510 100.00 Very High Very High Very High
metalloproteinase 305 100.00 Very High Very High Very High
ischemia 292 100.00 Very High Very High Very High
Pain 107 99.90 Very High Very High Very High
Paracetamol 49 99.82 Very High Very High Very High
Central nervous system 2126 99.80 Very High Very High Very High
Neuropathic pain 18 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5614 100.00 Very High Very High Very High
Cancer 960 100.00 Very High Very High Very High
Obesity 873 100.00 Very High Very High Very High
Adhesions 815 100.00 Very High Very High Very High
Necrosis 356 100.00 Very High Very High Very High
Cv General 4 Under Development 70 100.00 Very High Very High Very High
Targeted Disruption 867 99.88 Very High Very High Very High
Glioblastoma 198 99.86 Very High Very High Very High
Atherosclerosis 461 99.84 Very High Very High Very High
Sarcoma 63 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.
Gene_expression (overexpressing) of CCL2 in astrocytes associated with nociception and chemokine
1) Confidence 0.78 Published 2007 Journal Neuroscience Section Title Doc Link 17870246 Disease Relevance 0.88 Pain Relevance 0.89
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.
Gene_expression (overexpressing) of chemokine ligand 2 in astrocytes associated with nociception and chemokine
2) Confidence 0.78 Published 2007 Journal Neuroscience Section Title Doc Link 17870246 Disease Relevance 0.87 Pain Relevance 0.88
The consistently observed decrease in CCL2 levels in the CSF during or even prior to a relapse generated alternative considerations.
Gene_expression (levels) of CCL2 associated with recurrence
3) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.70 Pain Relevance 0.30
Jee et al [15] compared the histological features and MCP-1 (CCL2) and CCR2 expression levels in the lesions of Lewis rats during the acute attack of monophasic EAE and during the first two clinical events of CR-EAE.
Gene_expression (expression) of CCL2 associated with multiple sclerosis
4) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.76 Pain Relevance 0.29
In contrast, decreased CCL2 was found in the CSF in all clinical forms of MS by Scarpini et al.[62] More consistently, however, low CCL2 levels were detected only during relapses by others [41,59,61,63,64].
Gene_expression (found) of CCL2 associated with multiple sclerosis and recurrence
5) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.98 Pain Relevance 0.44
In mice, the increased expression of MCP-1 (CCL2) by CNS immune cells is closely associated with the clinical activity of EAE [12-14].
Gene_expression (expression) of MCP-1 in immune cells associated with multiple sclerosis and central nervous system
6) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.06 Pain Relevance 0.42
Substantial MCP-1 (CCL2) expression may only occur in the late phase of acute disease and in the relapsing phases of CR-EAE.
Gene_expression (expression) of MCP-1 associated with multiple sclerosis and acute disease
7) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.26 Pain Relevance 0.30
While high numbers of MNCs expressing CCL2 and CCL5 were found in some patients, overall no differences were observed between MS and acute meningitis.
Gene_expression (expressing) of CCL2 associated with multiple sclerosis and meningitis
8) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.73 Pain Relevance 0.71
Jee et al [15] compared the histological features and MCP-1 (CCL2) and CCR2 expression levels in the lesions of Lewis rats during the acute attack of monophasic EAE and during the first two clinical events of CR-EAE.
Gene_expression (expression) of MCP-1 associated with multiple sclerosis
9) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.76 Pain Relevance 0.29
Some studies, however, suggest that the presence of leukocytes is necessary for the production of CCL2 by astrocytes, as the expression of CCL2 prior to the accumulation of inflammatory mononuclear cells has not been observed in the CNS.
Gene_expression (expression) of CCL2 in mononuclear cells associated with inflammation and central nervous system
10) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.30 Pain Relevance 0.38
In mice, the increased expression of MCP-1 (CCL2) by CNS immune cells is closely associated with the clinical activity of EAE [12-14].
Gene_expression (expression) of CCL2 in immune cells associated with multiple sclerosis and central nervous system
11) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.06 Pain Relevance 0.42
Vice versa, CCL2 expression is controlled by TH2 cytokines such as IL4.
Gene_expression (expression) of CCL2 associated with cytokine
12) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.62 Pain Relevance 0.29
In contrast, decreased CCL2 was found in the CSF in all clinical forms of MS by Scarpini et al.[62] More consistently, however, low CCL2 levels were detected only during relapses by others [41,59,61,63,64].
Gene_expression (detected) of CCL2 associated with multiple sclerosis and recurrence
13) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.02 Pain Relevance 0.47
Using methods of immunohistochemistry and in situ hybridization, McManus et al [46] investigated the expression of three monocyte chemoattractant proteins, MCP-1 (CCL2), MCP-2 (CCL8) and MCP-3 (CCL7) in correlation with the temporal evolution of plaques.
Spec (investigated) Gene_expression (expression) of CCL2 in plaques
14) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.94 Pain Relevance 0.27
In sum, the above data suggest that CCL1, CCL2, CCL3, CCL4, CCL5, CCL7 and CCL8 are expressed by residential glia and perivascular leukocytes in plaques.
Gene_expression (expressed) of CCL2 in plaques
15) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.56 Pain Relevance 0.64
Some studies, however, suggest that the presence of leukocytes is necessary for the production of CCL2 by astrocytes, as the expression of CCL2 prior to the accumulation of inflammatory mononuclear cells has not been observed in the CNS.
Gene_expression (production) of CCL2 in mononuclear cells associated with inflammation and central nervous system
16) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.23 Pain Relevance 0.38
Substantial MCP-1 (CCL2) expression may only occur in the late phase of acute disease and in the relapsing phases of CR-EAE.
Gene_expression (expression) of CCL2 associated with multiple sclerosis and acute disease
17) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.26 Pain Relevance 0.30
With the exception of well defined changes in the CCL2, CCL3 and CCL5 levels in the CSF during relapses, most investigators observed no differences in various clinical forms of the disease [56,61,64,66].
Gene_expression (levels) of CCL2 associated with disease and recurrence
18) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.33 Pain Relevance 0.76
In concert with the mouse data [4,13], not only higher numbers of macrophages infiltrated the spinal cord during the first and second attacks of CR-EAE as compared to those at the peak of acute EAE in these rats, but the expression of MCP-1 (CCL2) was also significantly higher in the lesion of CR-EAE as compared to that of acute EAE.
Gene_expression (expression) of CCL2 in spinal cord associated with multiple sclerosis and spinal cord
19) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.69 Pain Relevance 0.15
In concert with the mouse data [4,13], not only higher numbers of macrophages infiltrated the spinal cord during the first and second attacks of CR-EAE as compared to those at the peak of acute EAE in these rats, but the expression of MCP-1 (CCL2) was also significantly higher in the lesion of CR-EAE as compared to that of acute EAE.
Gene_expression (expression) of MCP-1 in spinal cord associated with multiple sclerosis and spinal cord
20) Confidence 0.75 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.69 Pain Relevance 0.15

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