INT102547

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 14.47
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd68) plasma membrane (Cd68) lysosome (Cd68)
Anatomy Link Frequency
macrophages 6
microglia 2
liver 1
fibroblast 1
kidney 1
Cd68 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 151 99.74 Very High Very High Very High
Paracetamol 18 99.40 Very High Very High Very High
narcan 3 98.32 Very High Very High Very High
Multiple sclerosis 51 98.30 Very High Very High Very High
Inflammation 307 97.36 Very High Very High Very High
Dorsal horn 14 96.48 Very High Very High Very High
rheumatoid arthritis 289 96.44 Very High Very High Very High
COX2 30 94.96 High High
opioid receptor 7 93.12 High High
Crohn's disease 36 91.84 High High
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 112 99.74 Very High Very High Very High
Metastasis 218 99.54 Very High Very High Very High
Synovitis 34 99.08 Very High Very High Very High
Inflammatory Bowel Disease 86 98.96 Very High Very High Very High
Colon Cancer 168 98.72 Very High Very High Very High
Demyelinating Disease 54 98.30 Very High Very High Very High
Body Weight 14 98.26 Very High Very High Very High
Cancer 512 98.16 Very High Very High Very High
Disease 320 97.40 Very High Very High Very High
INFLAMMATION 314 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, expression of macrosialin (CD68), a marker of activated macrophages, increased 2-fold 24 to 72 hours after administration of acetaminophen and was associated with inflammatory cells.
Gene_expression (expression) of macrosialin in macrophages associated with paracetamol and inflammation
1) Confidence 0.75 Published 2002 Journal Hepatology Section Abstract Doc Link 11981759 Disease Relevance 0.74 Pain Relevance 0.86
Immunofluorescence analyses were carried out for the detection of NeuN, GFAP and CD68 (36,37) and for the co-localization signal of Lamp2-hIDS.
Gene_expression (detection) of CD68
2) Confidence 0.75 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2989894 Disease Relevance 0.09 Pain Relevance 0
In contrast, expression of macrosialin (CD68), a marker of activated macrophages, increased 2-fold 24 to 72 hours after administration of acetaminophen and was associated with inflammatory cells.
Gene_expression (expression) of CD68 in macrophages associated with paracetamol and inflammation
3) Confidence 0.67 Published 2002 Journal Hepatology Section Abstract Doc Link 11981759 Disease Relevance 0.74 Pain Relevance 0.86
A multivariate Cox proportional hazards analysis was performed, including gender, age, sites of primary tumors, invasive depth, grade, pathologic classifications, liver metastasis, growth patterns, and CD68TFHotspot groups.
Gene_expression (groups) of CD68TFHotspot in liver associated with cancer and metastasis
4) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.61 Pain Relevance 0
There was a positive association between the CD68TFHotspot group and both OS (P < 0.001) and LMFS (P = 0.037; Fig. 3).


Gene_expression (group) of CD68TFHotspot
5) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.64 Pain Relevance 0.05
CD68 evaluation
Gene_expression (evaluation) of CD68
6) Confidence 0.64 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.25 Pain Relevance 0
Glomerular volume and expression of PCNA, Thy1, and ED1/CD68 were analyzed in kidney sections.
Spec (analyzed) Gene_expression (expression) of CD68 in kidney
7) Confidence 0.58 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18385270 Disease Relevance 0.49 Pain Relevance 0.60
CD68 expression
Gene_expression (expression) of CD68
8) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 0.49 Pain Relevance 0
As shown in more detail in Table 3 (top), lining-layer thickness, sublining CD68, and sublining CD163 were weakly but significantly correlated with the SJC in SpA.
Gene_expression (sublining) of CD68
9) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.73 Pain Relevance 0.19
We previously shown that these CD163+ macrophages, but not the overall number of CD68+ macrophages, are increased in SpA synovitis and play a specific role in the disease pathogenesis [2,26].
Gene_expression (macrophages) of CD68 in macrophages associated with synovitis and disease
10) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.20 Pain Relevance 0.20
We also observed CD11c adjacent to mannose receptor and CD68 positive cells within the vasculature of TGRUN.
Gene_expression (adjacent) of CD68 in vasculature
11) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.08 Pain Relevance 0
In addition, increased numbers of CD68-positive macrophages were detected in db/db mouse LDRG, suggesting the involvement of cell-mediated inflammation (Fig. 6K).
Gene_expression (detected) of CD68 in macrophages associated with inflammation
12) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.22 Pain Relevance 0.40
+/+ mice had similar heart–to–body weight ratios and cardiomyocyte diameters (Table 2), cardiac fibrosis and myocardial OPN and CD68 mRNA expression (Fig. 5A–D), and circulating monocyte levels (data not shown).
Gene_expression (expression) of CD68 mRNA in monocyte associated with fibrosis, body weight and cardiovascular disorder under development
13) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.06 Pain Relevance 0.36
mice (Table 2, two-way ANOVA), but reduced AngII-mediated cardiac fibrosis and OPN and CD68 gene expression in mPPAR?
Gene_expression (expression) of CD68 gene associated with fibrosis and cardiovascular disorder under development
14) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.10 Pain Relevance 0.33
CD68 is a transmembrane 37 kDa glycosylated protein expressed by tissue macrophages and activated microglia [36].
Gene_expression (expressed) of CD68 in microglia
15) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 0.21 Pain Relevance 0.26
All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).
Gene_expression (antibodies) of CD68 in fibroblast
16) Confidence 0.32 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.11 Pain Relevance 0.06
The CXCR1 protein was weakly expressed on CD68+ macrophages in a diffuse manner and showed a consistent distribution pattern within all sections of RA patients (data not shown).
Gene_expression (macrophages) of CD68 in macrophages associated with rheumatoid arthritis
17) Confidence 0.32 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.70 Pain Relevance 0.35
In addition, cells expressing high levels of molecules involved in antigen presentation such as MHC class II, CD11c, and CD68 were elevated [165].
Gene_expression (expressing) of CD68
18) Confidence 0.32 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.57 Pain Relevance 0.14
After cooling, monoclonal mouse anti-human CD68 clone PGM1 (DAKO, Denmark, 1?
Gene_expression (clone) of CD68
19) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 0.53 Pain Relevance 0
After cooling, monoclonal mouse anti-human CD68 clone PGM1 (DAKO, Denmark, 1?
Gene_expression (human) of CD68
20) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 0.59 Pain Relevance 0

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