INT102550

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 4.53
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
monocytes 6
neurons 4
spinal 2
macrophage 2
sciatic nerves 2
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 231 99.32 Very High Very High Very High
chemokine 66 98.74 Very High Very High Very High
cytokine 21 98.24 Very High Very High Very High
Paracetamol 9 97.00 Very High Very High Very High
Spinal cord 14 95.96 Very High Very High Very High
Inflammatory mediators 8 87.00 High High
Multiple sclerosis 16 77.44 Quite High
Neurobehavioral 7 74.64 Quite High
antagonist 30 74.08 Quite High
rheumatoid arthritis 6 59.92 Quite High
Disease Link Frequency Relevance Heat
Disease 116 100.00 Very High Very High Very High
INFLAMMATION 256 99.32 Very High Very High Very High
Hepatotoxicity 3 99.04 Very High Very High Very High
Multiple Sclerosis 317 97.68 Very High Very High Very High
Targeted Disruption 95 92.48 High High
Pulmonary Disease 107 92.32 High High
Peritonitis 49 77.52 Quite High
Demyelinating Disease 2 77.44 Quite High
Shock 2 72.04 Quite High
Experimental Autoimmune Neuritis 2 67.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional signals might initiate CCR2 translation in these monocytes and thus provide the potential to rapidly upregulate CCR2 expression.
Positive_regulation (upregulate) of Gene_expression (expression) of CCR2 in monocytes
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.45 Pain Relevance 0.10
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Gene_expression (expressed) of Ccr2
2) Confidence 0.55 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
While most but not all Ly6Clo monocytes were negative for CCR2 staining, some Ly6Clo monocytes expressed CCR2 at levels similar to those in Ly6Chi monocytes.
Positive_regulation (negative) of Gene_expression (staining) of CCR2 in monocytes
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.19 Pain Relevance 0.03
This finding most likely accounts for the similar peak disease severity in the Ccr2+/RFP and Ccr2RFP/RFP mice, since the neurological signs of EAE arise from spinal-cord involvement [30].
Positive_regulation (accounts) of Gene_expression (/) of Ccr2 in spinal associated with multiple sclerosis and disease
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 1.12 Pain Relevance 0.18
We found that hepatic expression of CCR2 and MCP-1 was increased 10-fold and 20-fold, respectively, 12 to 72 hours after administration of acetaminophen to wild-type mice.
Positive_regulation (increased) of Gene_expression (expression) of CCR2 associated with paracetamol
5) Confidence 0.50 Published 2002 Journal Hepatology Section Abstract Doc Link 11981759 Disease Relevance 0.44 Pain Relevance 0.51
As expected from the Ccr2RFP mice (Figure 2F,G), virtually all of the Ly6Chi monocytes were markedly positive for both RFP and CCR2 staining (Figure 2J).
Positive_regulation (positive) of Gene_expression (staining) of CCR2 in monocytes
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.14 Pain Relevance 0.04
The findings of studies using tissue immunohistochemistry and receptor autoradiography have suggested constitutive or inducible expression of CCR2 by neuroepithelial cells (e.g., neurons, astrocytes, neural stem cells) (reviewed in [31]).
Positive_regulation (inducible) of Gene_expression (expression) of CCR2 in neurons
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0.03
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Gene_expression (expressed) of Ccr2
8) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
RESULTS: CCL2/CCR2, CXCL10/CXCR3 and CCL5/CCR1, CCR5 expression was significantly increased in the sciatic nerves of sm-EAN mice compared with controls.
Positive_regulation (creased i) of Gene_expression (pression w) of CCR2 in sciatic nerves
9) Confidence 0.39 Published 2010 Journal Neuropathol. Appl. Neurobiol. Section Body Doc Link 20500551 Disease Relevance 0.07 Pain Relevance 0
Migration of monocytes/macrophages is mainly mediated by CC chemokines including monocyte chemoattractant protein 1 (MCP-1 or CCL2), acting on its CCR2 receptor, and macrophage inflammatory proteins 1?
Positive_regulation (acting) of Gene_expression (receptor) of CCR2 in macrophage associated with chemokine and inflammation
10) Confidence 0.16 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.89 Pain Relevance 0.42
The findings of studies using tissue immunohistochemistry and receptor autoradiography have suggested constitutive or inducible expression of CCR2 by neuroepithelial cells (e.g., neurons, astrocytes, neural stem cells) (reviewed in [31]).
Positive_regulation (inducible) of in neural Gene_expression (expression) of CCR2 in neurons
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0.03
The findings of studies using tissue immunohistochemistry and receptor autoradiography have suggested constitutive or inducible expression of CCR2 by neuroepithelial cells (e.g., neurons, astrocytes, neural stem cells) (reviewed in [31]).
Positive_regulation (inducible) of in astrocytes Gene_expression (expression) of CCR2 in neurons
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0.03

General Comments

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