INT102552

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) cell morphogenesis (HGF)
Golgi apparatus (MAPK3) protein complex assembly (MAPK3) protein complex (MAPK3)
Anatomy Link Frequency
HGF 1
HGF (Homo sapiens)
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 94.12 High High
metalloproteinase 3 89.24 High High
COX-2 inhibitor 1 72.92 Quite High
cINOD 2 56.44 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 4 75.08 Quite High
Cancer 2 69.24 Quite High
Metastasis 1 67.56 Quite High
INFLAMMATION 1 55.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, both agents inhibited the kinase activity of ERK1/2 induced by HGF and repressed HGF-induced phosphorylation of 90-kd ribosomal S6 kinase (RSK) and Elk-1, key downstream substrates of ERK1/2, resulting in the suppression of transcriptional activity of Elk-1 as well as nuclear factor kappaB (NF-kappaB) and AP-1, which are involved in MMP-9 gene regulation.
HGF Positive_regulation (induced) of ERK1 in HGF associated with metalloproteinase
1) Confidence 0.38 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.47 Pain Relevance 0.47

General Comments

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