INT102561

Context Info Confidence 0.12 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 3 Disease Relevance 1.39 Pain Relevance 1.42

nucleus (ELK1)

Anatomy Link Frequency HGF 6 ELK1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 9 99.84 aspirin 18 94.64 COX-2 inhibitor 3 71.88 cINOD 6 55.40 COX2 3 25.00

Disease Link Frequency Relevance Heat Hepatocellular Cancer 12 75.00 Cancer 6 68.20 Metastasis 3 66.52 INFLAMMATION 3 54.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, both agents inhibited the kinase activity of ERK1/2 induced by HGF and repressed HGF-induced phosphorylation of 90-kd ribosomal S6 kinase (RSK) and Elk-1, key downstream substrates of ERK1/2, resulting in the suppression of transcriptional activity of Elk-1 as well as nuclear factor kappaB (NF-kappaB) and AP-1, which are involved in MMP-9 gene regulation.

Positive_regulation (resulting) of Phosphorylation (phosphorylation) of Elk-1 in HGF associated with metalloproteinase

1) Confidence 0.12 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.46 Pain Relevance 0.47

However, both agents inhibited the kinase activity of ERK1/2 induced by HGF and repressed HGF-induced phosphorylation of 90-kd ribosomal S6 kinase (RSK) and Elk-1, key downstream substrates of ERK1/2, resulting in the suppression of transcriptional activity of Elk-1 as well as nuclear factor kappaB (NF-kappaB) and AP-1, which are involved in MMP-9 gene regulation.

Positive_regulation (involved) of Phosphorylation (phosphorylation) of Elk-1 in HGF associated with metalloproteinase

2) Confidence 0.12 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.46 Pain Relevance 0.48

However, both agents inhibited the kinase activity of ERK1/2 induced by HGF and repressed HGF-induced phosphorylation of 90-kd ribosomal S6 kinase (RSK) and Elk-1, key downstream substrates of ERK1/2, resulting in the suppression of transcriptional activity of Elk-1 as well as nuclear factor kappaB (NF-kappaB) and AP-1, which are involved in MMP-9 gene regulation.

Positive_regulation (repressed) of Phosphorylation (phosphorylation) of Elk-1 in HGF associated with metalloproteinase

3) Confidence 0.12 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.47 Pain Relevance 0.47

General Comments

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