INT102562

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (HGF) extracellular space (HGF) extracellular region (HGF)
cell morphogenesis (HGF)
Anatomy Link Frequency
HGF 6
HGF (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 97.20 Very High Very High Very High
metalloproteinase 3 90.00 High High
COX-2 inhibitor 1 81.64 Quite High
cytokine 2 73.76 Quite High
cINOD 2 65.16 Quite High
COX2 1 25.00 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 94.80 High High
Hepatocellular Cancer 40 90.64 High High
Cancer 16 88.96 High High
Metastasis 1 76.28 Quite High
INFLAMMATION 3 64.60 Quite High
Myocardial Infarction 1 50.56 Quite High
Coronary Artery Disease 1 50.00 Quite Low
Cv General 3 Under Development 1 49.08 Quite Low
Apoptosis 6 34.64 Quite Low
Cirrhosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of aspirin or NS-398, similar to PD98059, which acts as a specific inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK), an upstream kinase regulating extracellular signal-regulated kinase (ERK)1/2, abrogated such actions of HGF without affecting cell viability.
Positive_regulation (abrogated) of Positive_regulation (actions) of HGF in HGF associated with aspirin
1) Confidence 0.36 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.52 Pain Relevance 0.49
CONCLUSION: While both myocardial and vascular damage contribute to an increase in HGF level, vascular damage is not associated with the increase in VEGF.
Positive_regulation (contribute) of Positive_regulation (increase) of HGF in HGF
2) Confidence 0.35 Published 2003 Journal Coron. Artery Dis. Section Body Doc Link 12826929 Disease Relevance 0.05 Pain Relevance 0
However, immortalization with SV40 induces HGF/c-MET activation via an autocrine HGF loop [9].
Positive_regulation (induces) of Positive_regulation (activation) of HGF in HGF
3) Confidence 0.25 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.35 Pain Relevance 0.04

General Comments

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