INT102570

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Context Info
Confidence 0.13
First Reported 2002
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat) extracellular region (Penk)
Anatomy Link Frequency
neurons 2
Abat (Rattus norvegicus)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 12 100.00 Very High Very High Very High
nMDA receptor 8 99.52 Very High Very High Very High
antagonist 2 98.32 Very High Very High Very High
projection neuron 4 90.56 High High
GABAergic 1 86.72 High High
Thalamus 2 69.36 Quite High
agonist 2 51.12 Quite High
Enkephalin 4 25.00 Low Low
Opioid 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these experiments we have used slice cultures of rat neostriatum to study the role of GABA in proenkephalin gene expression.
GABA Regulation (role) of Gene_expression (expression) of proenkephalin gene associated with gaba
1) Confidence 0.13 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 11982623 Disease Relevance 0 Pain Relevance 0.45
Our results show that GABA is released from neostriatal neurons and negatively regulates the proenkephalin gene expression induced by NMDA receptor stimulation.
GABA Regulation (regulates) of Gene_expression (expression) of proenkephalin gene in neurons associated with gaba and nmda receptor
2) Confidence 0.11 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 11982623 Disease Relevance 0 Pain Relevance 0.50
In the present study, we have investigated how GABA regulates the expression of the proenkephalin gene.
GABA Spec (investigated) Regulation (regulates) of Gene_expression (expression) of proenkephalin gene associated with gaba
3) Confidence 0.08 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12732927 Disease Relevance 0 Pain Relevance 0.17

General Comments

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