INT102572

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 79
Total Number 81
Disease Relevance 56.37
Pain Relevance 7.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
hepatocytes 2
biliary tract 2
HPAC 1
CB1 1
nucleus 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 2 99.92 Very High Very High Very High
Paracetamol 43 99.82 Very High Very High Very High
Hippocampus 51 99.40 Very High Very High Very High
Bile 152 98.68 Very High Very High Very High
metalloproteinase 15 98.68 Very High Very High Very High
Endocannabinoid 3 98.44 Very High Very High Very High
Chronic pancreatitis 28 96.40 Very High Very High Very High
Eae 42 96.24 Very High Very High Very High
cytokine 93 95.28 Very High Very High Very High
palliative 25 94.96 High High
Disease Link Frequency Relevance Heat
Cancer 2116 100.00 Very High Very High Very High
Sprains And Strains 39 100.00 Very High Very High Very High
Pancreatic Cancer 273 99.84 Very High Very High Very High
Colon Cancer 207 99.84 Very High Very High Very High
Carcinoma 31 99.84 Very High Very High Very High
Biliary Cancer 220 99.62 Very High Very High Very High
Apoptosis 1065 99.60 Very High Very High Very High
Pituitary Cancer 1 99.58 Very High Very High Very High
Hepatotoxicity 9 99.36 Very High Very High Very High
Targeted Disruption 255 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Gene_expression (expression) of cyclin D1
1) Confidence 0.69 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.86 Pain Relevance 0.14
Furthermore, these mice had a 24-hr lag in the hepatic expression of the G1/S checkpoint regulator genes cyclin D1 (Ccnd1) and c-myc and increased expression of the interleukin-1?
Gene_expression (expression) of Ccnd1
2) Confidence 0.69 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.86 Pain Relevance 0.14
We also noted the re-expression of cyclin D1, which was down-regulated in the stable 199bSC1 clone.
Gene_expression (-) of cyclin D1
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.25 Pain Relevance 0
Third, we assessed the expression level of S100beta protein in the CD1 wild type mice after nerve injury.
Gene_expression (expression) of CD1 in nerve associated with nervous system injury
4) Confidence 0.68 Published 2006 Journal Neuroscience Section Abstract Doc Link 16600520 Disease Relevance 1.00 Pain Relevance 0.50
CD1 mice lacking the CB1 receptors ("knockout" [KO] mutants) were compared with wildtype (WT) littermates for their ability to degrade AEA through an AEA membrane transporter (AMT) and an AEA hydrolase (fatty acid amide hydrolase, FAAH).
Neg (lacking) Gene_expression (lacking) of CD1 in CB1 associated with targeted disruption
5) Confidence 0.65 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 11982628 Disease Relevance 0.17 Pain Relevance 0.24
Treatment with GSH after AAP induced expression of cyclin D1, p21, and PCNA (12-48 h).
Gene_expression (expression) of cyclin D1 associated with paracetamol
6) Confidence 0.63 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.34 Pain Relevance 0.63
Expression of proliferating cell nuclear antigen (PCNA) and cell cycle proteins cyclin D1 and p21 were not detectable in controls or after AAP alone.
Gene_expression (Expression) of cyclin D1 associated with paracetamol
7) Confidence 0.63 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.43 Pain Relevance 0.75
Notably, Sox17 enhanced cyclin D1 expression in vivo and activated cyclin D1 promoter activity in vitro.
Gene_expression (expression) of cyclin D1
8) Confidence 0.60 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Notably, forced expression of cyclin D1 along with cdk4 is sufficient to reinitiate cell cycle progression in multiple post-mitotic cell types [47], [48].
Gene_expression (expression) of cyclin D1
9) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Sox17 induces cyclin D1 expression
Gene_expression (expression) of cyclin D1
10) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
No significant differences were found in the expression of p53, cyclin D1, survivin, and ERCC1 between GB cancer and BDC.
Gene_expression (expression) of cyclin D1 associated with klatskin's tumor and cancer
11) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.25 Pain Relevance 0
Among all cases on which interpretation of immunohistochemistry was possible, 72 cases (56.7%) and 35 cases (26.7%) showed positive expression for p53 and cyclin D1, respectively, 54 cases (41.9%) for survivin, and 78 cases (65.0%) for TP.
Gene_expression (expression) of cyclin D1
12) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.87 Pain Relevance 0
In our study, there was no difference in p53 and cyclin D1 overexpression based on anatomic site, and also they were no prognostic impact on survival in BDC and GB cancer, respectively.
Gene_expression (overexpression) of cyclin D1 associated with klatskin's tumor and cancer
13) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.47 Pain Relevance 0.04
They presented that cyclin D1 overexpression was more common in extrahepatic bile duct cancer than in GB cancer.
Gene_expression (overexpression) of cyclin D1 in bile duct associated with bile and cancer
14) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.62 Pain Relevance 0.05
We assessed the expression of p53, cyclin D1 and survivin, to compare the differences in molecular changes associated with the prognosis between BDC and GB cancer.
Gene_expression (expression) of cyclin D1 associated with klatskin's tumor and cancer
15) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 2.16 Pain Relevance 0
According to their results, cyclin D1 overexpression varied based on anatomic site, and it was less common in GB cancer.
Gene_expression (overexpression) of cyclin D1 associated with cancer
16) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.52 Pain Relevance 0.04
On day 1.5, lidocaine upregulated expression of cyclin-D1 and cyclin-dependent kinase inhibitor 1A [p21].
Gene_expression (expression) of cyclin-D1
17) Confidence 0.54 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
We also noted the re-expression of cyclin D1, which was down-regulated in the stable 199bSC1 clone.
Gene_expression (expression) of cyclin D1
18) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.25 Pain Relevance 0
While we favor the notion that Sox17 directly activates the cyclin D1 promoter, it is possible that inhibiting TGF-?
Gene_expression (directly) of cyclin D1
19) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.19 Pain Relevance 0
Therefore, prognostic significance of cell cycle regulatory protein such as p53 and cyclin D1 and anti-apoptosis protein, survivin, has been investigated in malignancies [10-13].
Spec (investigated) Gene_expression (significance) of cyclin D1 associated with apoptosis
20) Confidence 0.51 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 2.10 Pain Relevance 0.04

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