INT102583

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 15.33
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 3
MCF-7 2
intestinal cells 1
SW480 1
liver 1
Gdf15 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 62 100.00 Very High Very High Very High
cytokine 48 100.00 Very High Very High Very High
Inflammation 27 96.88 Very High Very High Very High
metalloproteinase 10 95.16 Very High Very High Very High
agonist 11 86.40 High High
Nerve growth factor 3 73.00 Quite High
antagonist 4 32.32 Quite Low
COX2 5 25.00 Low Low
fibrosis 8 10.32 Low Low
Angina 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 100.00 Very High Very High Very High
Apoptosis 51 99.84 Very High Very High Very High
Colon Cancer 19 99.84 Very High Very High Very High
Cancer 153 99.82 Very High Very High Very High
Myocardial Infarction 86 97.88 Very High Very High Very High
Thalassemia 36 97.16 Very High Very High Very High
Injury 3 95.92 Very High Very High Very High
Death 29 95.48 Very High Very High Very High
Targeted Disruption 1 92.20 High High
Autoimmune Hemolytic Anemia 1 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAG-1 small interfering RNA blocked NAG-1 expression and 5F203-induced apoptosis in MCF-7 cells, indicating that NAG-1 may mediate the apoptosis and anticancer activity.
Gene_expression (expression) of NAG-1 in MCF-7 associated with apoptosis
1) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.66 Pain Relevance 0.24
Extracellular signal-regulated kinase (ERK) 1/2 phosphorylation was increased by 5F203, and inhibition of ERK1/2 phosphorylation abolished the induction of NAG-1 protein expression and increased the stability of NAG-1 mRNA.
Gene_expression (expression) of NAG-1 protein
2) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.82 Pain Relevance 0.22
Treatment of the mice with Phortress, the prodrug of 5F203, increased the in vivo expression of NAG-1 as measured by real-time reverse transcription-polymerase chain reaction from RNA obtained by needle biopsy, and the expression correlated with a reduction of tumor volume.
Gene_expression (expression) of NAG-1 associated with cancer
3) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.85 Pain Relevance 0.20
This localization and lower expression in tumors was similar to that in the Min mouse, in which NSAIDs were also shown to regulate the expression of NAG-1 in mouse cells.
Gene_expression (expression) of NAG-1
4) Confidence 0.76 Published 2002 Journal Gastroenterology Section Body Doc Link 11984525 Disease Relevance 0.06 Pain Relevance 0
Sulindac treatment of mice increased the NAG-1 expression in the colon and liver.
Gene_expression (expression) of NAG-1 in liver
5) Confidence 0.76 Published 2002 Journal Gastroenterology Section Body Doc Link 11984525 Disease Relevance 0.06 Pain Relevance 0
Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue.
Gene_expression (Expression) of NAG-1 associated with inflammation, cinod and cytokine
6) Confidence 0.76 Published 2002 Journal Gastroenterology Section Title Doc Link 11984525 Disease Relevance 0.20 Pain Relevance 0.49
GDF-15 expression correlates with apoptosis in intestinal cells and has been implicated in the pathogenesis of colorectal cancer formation and the anti-tumor effects of NSAIDs.
Gene_expression (expression) of GDF-15 in intestinal cells associated with cancer, colon cancer, cinod and apoptosis
7) Confidence 0.67 Published 2010 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 19784846 Disease Relevance 0.64 Pain Relevance 0.37
A mouse orthotopic mammary tumor model was used to determine whether 5F203 increased NAG-1 expression in vivo and suppressed tumor growth.
Gene_expression (expression) of NAG-1 associated with cancer
8) Confidence 0.67 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.85 Pain Relevance 0.20
The experimental anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) was a potent inducer of NAG-1 expression, and in MCF-7 cells, it inhibited cell growth and induced apoptosis.
Gene_expression (expression) of NAG-1 in MCF-7 associated with apoptosis
9) Confidence 0.67 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.59 Pain Relevance 0.25
One mechanism by which 5F203 increases NAG-1 expression is by increasing the stability of NAG-1 mRNA, dependent of de novo protein synthesis.
Gene_expression (expression) of NAG-1
10) Confidence 0.67 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.71 Pain Relevance 0.23
Thus, 5F203 regulates NAG-1 expression by a unique mechanism compared with other drugs.
Gene_expression (expression) of NAG-1
11) Confidence 0.67 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.84 Pain Relevance 0.21
Apoptosis in NAG-1 overexpressing HCT-116 cells was examined with flow cytometry after cell sorting by green fluorescence protein.
Gene_expression (overexpressing) of NAG-1
12) Confidence 0.67 Published 2002 Journal Gastroenterology Section Body Doc Link 11984525 Disease Relevance 0.09 Pain Relevance 0
However, NAG-1 expression and its relationship with apoptosis in human and mouse intestinal tract have not been determined.
Gene_expression (expression) of NAG-1 associated with apoptosis
13) Confidence 0.67 Published 2002 Journal Gastroenterology Section Abstract Doc Link 11984525 Disease Relevance 0.27 Pain Relevance 0.36
The results suggest that a possible inverse relationship exists between the expression of NAG-1 and COX-2 in tumor formation of colon tissue.
Gene_expression (expression) of NAG-1 in colon associated with cancer
14) Confidence 0.56 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19375854 Disease Relevance 0.59 Pain Relevance 0.19
To address the relationship between COX-2 and NAG-1 expression, we investigated the expression of NAG-1 and COX-2 in normal and tumor tissue from human patients, Apc(Min/+) mice, and COX-2(-/-) mice.
Spec (investigated) Gene_expression (expression) of NAG-1 associated with cancer
15) Confidence 0.56 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19375854 Disease Relevance 0.55 Pain Relevance 0.22
To address the relationship between COX-2 and NAG-1 expression, we investigated the expression of NAG-1 and COX-2 in normal and tumor tissue from human patients, Apc(Min/+) mice, and COX-2(-/-) mice.
Gene_expression (expression) of NAG-1 associated with cancer
16) Confidence 0.56 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19375854 Disease Relevance 0.54 Pain Relevance 0.23
METHODS: NAG-1 expression in human and mouse tissue was determined by immunohistochemistry, and apoptosis was estimated by in situ apoptosis detection.
Gene_expression (expression) of NAG-1
17) Confidence 0.52 Published 2002 Journal Gastroenterology Section Body Doc Link 11984525 Disease Relevance 0.10 Pain Relevance 0
RESULTS: Apoptosis was higher in NAG-1 overexpressing cells compared with controls.
Gene_expression (overexpressing) of NAG-1
18) Confidence 0.52 Published 2002 Journal Gastroenterology Section Body Doc Link 11984525 Disease Relevance 0.08 Pain Relevance 0
While COX-2 expression is highly induced in tumor tissue, NAG-1 expression is reduced.
Gene_expression (expression) of NAG-1 associated with cancer
19) Confidence 0.49 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19375854 Disease Relevance 0.53 Pain Relevance 0.21
Furthermore, PGE(2) reduces NAG-1 while celebrex induces NAG-1 expression.
Gene_expression (expression) of NAG-1
20) Confidence 0.49 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19375854 Disease Relevance 0.51 Pain Relevance 0.20

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