INT102585

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 14.78
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SW480 1
14.1 1
colon 1
RKO 1
MDA-MB-453 1
Gdf15 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 37 100.00 Very High Very High Very High
Inflammation 28 99.88 Very High Very High Very High
antagonist 25 99.44 Very High Very High Very High
COX2 2 98.44 Very High Very High Very High
agonist 55 88.68 High High
cytokine 25 87.84 High High
metalloproteinase 23 76.12 Quite High
Nerve growth factor 2 70.52 Quite High
fibrosis 8 24.16 Low Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 59 99.98 Very High Very High Very High
Thalassemia 36 99.84 Very High Very High Very High
Prostate Cancer 5 99.48 Very High Very High Very High
Sickle Cell Anemia 86 99.24 Very High Very High Very High
Colon Cancer 28 99.24 Very High Very High Very High
Myocardial Infarction 172 98.80 Very High Very High Very High
Cancer 481 98.68 Very High Very High Very High
Breast Cancer 295 98.48 Very High Very High Very High
Apoptosis 55 97.24 Very High Very High Very High
Death 62 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One mechanism by which 5F203 increases NAG-1 expression is by increasing the stability of NAG-1 mRNA, dependent of de novo protein synthesis.
Positive_regulation (increasing) of NAG-1 mRNA
1) Confidence 0.69 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.72 Pain Relevance 0.23
Extracellular signal-regulated kinase (ERK) 1/2 phosphorylation was increased by 5F203, and inhibition of ERK1/2 phosphorylation abolished the induction of NAG-1 protein expression and increased the stability of NAG-1 mRNA.
Positive_regulation (stability) of NAG-1 mRNA
2) Confidence 0.50 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16714403 Disease Relevance 0.83 Pain Relevance 0.22
BACKGROUND & AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce NSAID-activated gene 1 (NAG-1), which has proapoptotic and antitumorigenic activities.
Positive_regulation (induce) of NAG-1 associated with inflammation and cinod
3) Confidence 0.46 Published 2002 Journal Gastroenterology Section Abstract Doc Link 11984525 Disease Relevance 0.17 Pain Relevance 0.37
Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) and COX-2 are involved in cellular processes such as inflammation, apoptosis, and tumorigenesis.
Positive_regulation (activated) of NAG-1 associated with inflammation, cinod and apoptosis
4) Confidence 0.36 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19375854 Disease Relevance 0.52 Pain Relevance 0.24
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.
Positive_regulation (activated) of NAG-1 associated with inflammation and cox2
5) Confidence 0.36 Published 2009 Journal Cancer Lett. Section Title Doc Link 19375854 Disease Relevance 0.56 Pain Relevance 0.29
Nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1), a transforming growth factor beta-like peptide, was also induced by these compounds, and the response was dependent on cell-context dependent activation of kinase pathways.
Positive_regulation (induced) of NAG-1 associated with inflammation and cinod
6) Confidence 0.36 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.55 Pain Relevance 0.14
However, inhibition of cell growth, induction of NAG-1 and activation of kinases by C-DIMs were not inhibited by PPARgamma antagonists.
Positive_regulation (induction) of NAG-1 associated with antagonist
7) Confidence 0.36 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.57 Pain Relevance 0.14
Despite the induction of NAG-1 and downregulation of the antiapoptotic protein survivin by C-DIMs in both MDA-MB-231 and MDA-MB-453 cells, apoptotic cell death was not observed.
Positive_regulation (induction) of NAG-1 in MDA-MB-231 associated with apoptosis and death
8) Confidence 0.26 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.59 Pain Relevance 0.14
Nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1), a transforming growth factor beta-like peptide, was also induced by these compounds, and the response was dependent on cell-context dependent activation of kinase pathways.
Positive_regulation (induced) of NAG-1 associated with inflammation and cinod
9) Confidence 0.26 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.55 Pain Relevance 0.14
GDF-15 levels are elevated in TM, but not in SCD.
Positive_regulation (elevated) of GDF-15 associated with sickle cell anemia and thalassemia
10) Confidence 0.14 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 1.26 Pain Relevance 0.08
DIM-C-pPhOCH(3) also induced phosphatidylinositol-3-kinase-dependent activation of early growth response gene-1 which, in turn, induced expression of the proapoptotic nonsteroidal anti-inflammatory drug-activated gene-1 (NAG1) in RKO and SW480 colon cancer cells.
Positive_regulation (drug-activated) of NAG1 in RKO associated with inflammation, colon cancer and cinod
11) Confidence 0.14 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 17957723 Disease Relevance 0.77 Pain Relevance 0.14
One study found that increasing tertiles of GDF-15 levels in patients presenting with NSTEACS was associated with an increasing risk (1.5%, 5% and 14.1% respectively) of death at one year (AUC of ROC 0.757) [46].
Positive_regulation (increasing) of GDF-15 in 14.1 associated with death
12) Confidence 0.12 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.13 Pain Relevance 0.04
However, GDF-15 is not specific for cardiovascular disorders and has been found to be elevated in a variety of malignancies (prostate, colon, glial).


Positive_regulation (elevated) of GDF-15 in colon
13) Confidence 0.12 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.05 Pain Relevance 0
Despite the induction of NAG-1 and downregulation of the antiapoptotic protein survivin by C-DIMs in both MDA-MB-231 and MDA-MB-453 cells, apoptotic cell death was not observed.
Positive_regulation (induction) of NAG-1 in MDA-MB-453 associated with apoptosis and death
14) Confidence 0.09 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.59 Pain Relevance 0.14
NAG-1 was upregulated in MDA-MB231 cells after treatment with 10 and 20 ?
Positive_regulation (upregulated) of NAG-1
15) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.52 Pain Relevance 0.17
In MDA-MB231 cells, ATF-3 and NAG-1 are upregulated through a PPAR-?
Positive_regulation (upregulated) of NAG-1
16) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.05 Pain Relevance 0.19
The induction of NAG-1 and ATF3 were not inhibited by the PPAR-?
Positive_regulation (induction) of NAG-1
17) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.55 Pain Relevance 0.17
NAG-1 is induced by multiple agents including CDIM compounds [26-28].
Positive_regulation (induced) of NAG-1
18) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.08 Pain Relevance 0.20
Our observation of ATF-3 and NAG-1 induction by CDIM9 may also contribute to tumor growth inhibition.
Positive_regulation (induction) of NAG-1 associated with cancer
19) Confidence 0.05 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.96 Pain Relevance 0.06
DIM-C-pPhOCH(3) also induced phosphatidylinositol-3-kinase-dependent activation of early growth response gene-1 which, in turn, induced expression of the proapoptotic nonsteroidal anti-inflammatory drug-activated gene-1 (NAG1) in RKO and SW480 colon cancer cells.
Positive_regulation (drug-activated) of NAG1 in SW480 associated with inflammation, colon cancer and cinod
20) Confidence 0.05 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 17957723 Disease Relevance 0.77 Pain Relevance 0.14

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