INT102611

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 74
Total Number 79
Disease Relevance 35.57
Pain Relevance 39.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
amygdala 12
spinal cord 12
neuronal 8
medulla 6
retina 4
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 511 100.00 Very High Very High Very High
amygdala 484 100.00 Very High Very High Very High
Eae 211 100.00 Very High Very High Very High
nMDA receptor 106 100.00 Very High Very High Very High
Dorsal horn neuron 103 100.00 Very High Very High Very High
medulla 13 100.00 Very High Very High Very High
Thalamus 12 100.00 Very High Very High Very High
dorsal root ganglion 5 100.00 Very High Very High Very High
Kinase C 129 99.98 Very High Very High Very High
qutenza 23 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 543 100.00 Very High Very High Very High
Diabetes Mellitus 532 100.00 Very High Very High Very High
Stress 258 100.00 Very High Very High Very High
Inflammatory Pain 146 100.00 Very High Very High Very High
Ganglion Cysts 17 100.00 Very High Very High Very High
Targeted Disruption 289 99.66 Very High Very High Very High
Nociception 321 99.58 Very High Very High Very High
Hypersensitivity 155 99.14 Very High Very High Very High
Hyperalgesia 358 99.04 Very High Very High Very High
Pain 392 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin decreased the activation of extracellular signal-regulated kinases (ERK) without markedly affecting p38 kinases.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK associated with qutenza
1) Confidence 0.58 Published 2010 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 20954075 Disease Relevance 0.51 Pain Relevance 0.86
However, we do show that the contribution of the spinal cord to the reduced behavioral effect is paramount since the activation of ERK1 and ERK2 is also decreased following formalin injection in the DN MEK mice relative to wild type littermates, and the behavioral and biochemical inhibition can be mimicked by intrathecal administration of MEK inhibitors.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK2 in spinal cord associated with intrathecal and spinal cord
2) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.25 Pain Relevance 0.30
Perhaps the larger suppression induced by intrathecally applied MEK inhibitors is due to inhibition of both neuronal and non-neuronal ERK activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of ERK in neuronal
3) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.28 Pain Relevance 0.13
Inhibition of persistent activation of ERK with either MEK inhibitors, or with overexpression of dominant negative MEK in the cultures, resulted in a decrease in cell death of the CGN [42,43].
Negative_regulation (Inhibition) of Positive_regulation (activation) of ERK in CGN associated with death
4) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.43 Pain Relevance 0.42
Moreover, GluA1 knockout mice showed the decreased cortical activation of ERK1/2 in vivo.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK1/2 associated with targeted disruption
5) Confidence 0.55 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.62 Pain Relevance 0.88
Moreover, the ERK activation was blocked in the presence of Na+-channel blocker tetrodotoxin, indicating the existence of a trans-synaptic activity in ERK activation by Hcy in hippocampal slices.
Negative_regulation (blocked) of Positive_regulation (activation) of ERK associated with tetrodotoxin
6) Confidence 0.48 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.22 Pain Relevance 0.31
protein function by simultaneous inhibition of the COX pathway-mediated activation of the ERK cascade: LY293111, an oral PPAR?
Negative_regulation (inhibition) of Positive_regulation (activation) of ERK cascade
7) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.92 Pain Relevance 0.12
Additionally, it has been reported that the blockade of ERK activation prevented LTP in the developing visual cortex and blocked the ocular dominance shift induced by monocular deprivation [47].
Negative_regulation (blockade) of Positive_regulation (activation) of ERK in cortex associated with long-term potentiation
8) Confidence 0.45 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0.22 Pain Relevance 0.63
Thus, blockade of inflammation-induced ERK activation in the amygdala significantly reduced long-lasting peripheral hypersensitivity associated with persistent inflammation, and pharmacological activation of ERK in the amygdala induced peripheral hypersensitivity in the absence of inflammation.
Negative_regulation (blockade) of Positive_regulation (activation) of ERK in amygdala associated with inflammation, hypersensitivity and amygdala
9) Confidence 0.43 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17301163 Disease Relevance 1.32 Pain Relevance 1.00
Cue-elicited drug craving represses ERK activation in mice prefrontal association cortex.
Negative_regulation (represses) of Positive_regulation (activation) of ERK in prefrontal
10) Confidence 0.43 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18940233 Disease Relevance 0.34 Pain Relevance 0.70
Furthermore, we found an acid-induced, Ca(v)3.2 T-channel-dependent activation of ERK (extracellular signal-regulated kinase) in the anterior nucleus of paraventricular thalamus (PVA), and prevention of the ERK activation abolished the chronic mechanical hyperalgesia.
Negative_regulation (abolished) of Positive_regulation (activation) of extracellular signal-regulated kinase in PVA associated with hyperalgesia and thalamus
11) Confidence 0.43 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20685979 Disease Relevance 0.85 Pain Relevance 1.08
Furthermore, we found an acid-induced, Ca(v)3.2 T-channel-dependent activation of ERK (extracellular signal-regulated kinase) in the anterior nucleus of paraventricular thalamus (PVA), and prevention of the ERK activation abolished the chronic mechanical hyperalgesia.
Negative_regulation (abolished) of Positive_regulation (activation) of ERK in PVA associated with hyperalgesia and thalamus
12) Confidence 0.43 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20685979 Disease Relevance 0.85 Pain Relevance 1.08
The single subcutaneous injection of morphine produced profound antinociception and an increase in phosphorylated-ERK (p-ERK) immunoreactivity in the pons/medulla, and these effects were blocked by a mu-opioid receptor antagonist, naloxone.
Negative_regulation (blocked) of Positive_regulation (increase) of ERK in medulla associated with medulla, antinociception, antagonist, narcan, opioid receptor and morphine
13) Confidence 0.42 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.37
The single subcutaneous injection of morphine produced profound antinociception and an increase in phosphorylated-ERK (p-ERK) immunoreactivity in the pons/medulla, and these effects were blocked by a mu-opioid receptor antagonist, naloxone.
Negative_regulation (blocked) of Positive_regulation (increase) of ERK in medulla associated with medulla, antinociception, antagonist, narcan, opioid receptor and morphine
14) Confidence 0.42 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.37
A significant inhibition of ERK activation was observed in all the analyzed regions of mice pre-treated with 30 mg/kg of SL327.
Negative_regulation (inhibition) of Positive_regulation (activation) of ERK
15) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.21
As illustrated in Figure 1, acute injection of SL327 at doses that significantly inhibited ERK activation (15, 30 mg/kg, Table 1) had no effect on the basal locomotor activity.
Negative_regulation (inhibited) of Positive_regulation (activation) of ERK associated with eae
16) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0.13 Pain Relevance 0.23
Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.
Negative_regulation (decreased) of Positive_regulation (activation) of ERK in hippocampus associated with qutenza, hippocampus and neurodegenerative disease
17) Confidence 0.42 Published 2010 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 20954075 Disease Relevance 0.56 Pain Relevance 0.85
Blockade of ERK activation in the left amygdala had no significant effect on formalin-induced primary or secondary hypersensitivity whether formalin was injected into the right or the left hind-paw (Fig 1c and 1d).
Negative_regulation (Blockade) of Positive_regulation (activation) of ERK in amygdala associated with hypersensitivity and amygdala
18) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 0.64 Pain Relevance 0.77
Thus, blockade of ERK activation in the right but not the left amygdala decreased inflammation-induced hypersensitivity independently of the side of peripheral inflammation.
Negative_regulation (blockade) of Positive_regulation (activation) of ERK in amygdala associated with inflammation, hypersensitivity and amygdala
19) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 0.78 Pain Relevance 0.92
We acutely blocked ERK activation in the CeA by infusing the MEK inhibitor U0126 into the right or the left hemisphere and then measured the behavioral effects on inflammation-induced mechanical hypersensitivity in mice.
Negative_regulation (blocked) of Positive_regulation (activation) of ERK in CeA associated with inflammation, hypersensitivity and amygdala
20) Confidence 0.41 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2443116 Disease Relevance 1.20 Pain Relevance 1.10

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