INT102627

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Context Info
Confidence 0.20
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) extracellular space (IL6) small molecule metabolic process (CPOX)
oxidoreductase activity (CPOX) aging (IL6) extracellular region (IL6)
IL6 (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 4 10.00 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Cancer 8 65.44 Quite High
Disease Progression 4 64.48 Quite High
Skin Cancer 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our data suggest that COX-2 expression in ESCC cells could be upregulated by PMA, PAF, n-BT and IL-6.
IL-6 Positive_regulation (upregulated) of Gene_expression (expression) of COX
1) Confidence 0.20 Published 2002 Journal Scand. J. Gastroenterol. Section Body Doc Link 11989839 Disease Relevance 0.10 Pain Relevance 0
Nonetheless, IL-6-induced COX-2 expression could be independent of PKC activation.


IL-6-induced Positive_regulation (induced) of Gene_expression (expression) of COX
2) Confidence 0.14 Published 2002 Journal Scand. J. Gastroenterol. Section Body Doc Link 11989839 Disease Relevance 0 Pain Relevance 0
PKC inhibitor, however, could abrogate PMA-induced COX-2 gene expression, but it did not block IL-6-induced COX-2 expression.
IL-6-induced Positive_regulation (induced) of Gene_expression (expression) of COX
3) Confidence 0.14 Published 2002 Journal Scand. J. Gastroenterol. Section Body Doc Link 11989839 Disease Relevance 0.11 Pain Relevance 0
The addition of IL-6 could also enhance COX-2 expression in ESCC cells.
IL-6 Positive_regulation (enhance) of Gene_expression (expression) of COX
4) Confidence 0.13 Published 2002 Journal Scand. J. Gastroenterol. Section Body Doc Link 11989839 Disease Relevance 0.13 Pain Relevance 0

General Comments

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