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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.81

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oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Cyp3a62 (Rattus norvegicus)
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 6 100.00 Very High Very High Very High
fluoxetine 7 99.24 Very High Very High Very High
Potency 1 94.92 High High
tricyclic antidepressant 1 76.24 Quite High
antidepressant 1 75.00 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, CYP1A2 was distinctly inhibited by imipramine and amitriptyline, CYP3A by imipramine and fluoxetine, while other CYP isoenzymes (CYP2B and/or 2E1) by imipramine and fluoxetine.
CYP3A Negative_regulation (inhibited) of CYP1A2 associated with endep and fluoxetine
1) Confidence 0.40 Published 2001 Journal Pol J Pharmacol Section Abstract Doc Link 11990081 Disease Relevance 0 Pain Relevance 0.81

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