INT102631

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.79
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HYAL1) hydrolase activity, acting on glycosyl bonds (HYAL1) cell death (HYAL1)
extracellular region (HYAL1) carbohydrate metabolic process (HYAL1) lysosome (HYAL1)
Anatomy Link Frequency
macrophages 1
HYAL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 1 99.98 Very High Very High Very High
Serotonin 1 99.70 Very High Very High Very High
Pain 12 92.80 High High
Hyperesthesia 1 89.12 High High
cryotherapy 1 73.20 Quite High
Osteoarthritis 44 68.16 Quite High
rheumatoid arthritis 43 55.96 Quite High
Arthritis 15 50.00 Quite Low
Inflammation 45 46.84 Quite Low
cytokine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bites And Stings 5 95.96 Very High Very High Very High
Pain 11 92.80 High High
Pressure And Volume Under Development 6 92.32 High High
Pressure Volume 2 Under Development 2 91.76 High High
Vomiting 5 90.72 High High
Hyperaesthesia 1 89.12 High High
Dizziness 1 82.08 Quite High
Monsters 2 75.00 Quite High
Osteoarthritis 44 68.16 Quite High
Rheumatoid Arthritis 44 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The venom contains a number of protein and nonprotein components including serotonin, a bradykinin-releasing substance, protease, hyaluronidase, helodermin, and gilatoxin.
Localization (releasing) of hyaluronidase associated with bradykinin and serotonin
1) Confidence 0.26 Published 1997 Journal Wilderness Environ Med Section Abstract Doc Link 11990142 Disease Relevance 1.55 Pain Relevance 0.39
Further characterization of the hyaluronidase activity present in cell-layer extracts and conditioned media
Localization (present) of hyaluronidase
2) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0 Pain Relevance 0
On the other hand, our view certainly does not present LUCA as a single species nor as a diversified community of species, since, following Woese, we do not think standard (Darwinian) species existed at the time of LUCA.
Neg (nor) Localization (present) of LUCA
3) Confidence 0.02 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0
Curcumin also inhibited the incorporation of arachidonic acid into membrane lipids, PGE2 production, leukotriene B4 and leukotriene C4 synthesis, as well as the secretion of collagenase, elastase and hyaluronidase by macrophages (78).
Neg (blocks) Localization (secretion) of hyaluronidase in macrophages
4) Confidence 0.00 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193557 Disease Relevance 0.24 Pain Relevance 0.06

General Comments

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