INT102634

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 4.50
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 5
macrophages 2
spinal cord 1
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 118 99.80 Very High Very High Very High
Glutamate 3 99.72 Very High Very High Very High
Paracetamol 23 99.10 Very High Very High Very High
Potency 35 98.50 Very High Very High Very High
Inflammation 191 98.40 Very High Very High Very High
Spinal cord 10 98.00 Very High Very High Very High
cva 1 96.92 Very High Very High Very High
methotrexate 10 93.24 High High
ischemia 2 88.44 High High
tolerance 216 74.32 Quite High
Disease Link Frequency Relevance Heat
Injury 15 99.92 Very High Very High Very High
Infection 2 99.78 Very High Very High Very High
Hepatitis C Virus Infection 2 99.56 Very High Very High Very High
Hepatitis 1 99.42 Very High Very High Very High
INFLAMMATION 247 98.40 Very High Very High Very High
Hemorrhage 1 96.92 Very High Very High Very High
Pressure And Volume Under Development 1 96.44 Very High Very High Very High
Spinal Cord Injury 6 95.56 Very High Very High Very High
Liver Disease 1 95.48 Very High Very High Very High
Stress 200 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heme oxygenase-1 (Ho-1), NAD(P)H quinone oxidoreductase-1 (Nqo1), organic anion-transporting polypeptides (Oatp1a1, 1a4 and 1b2), sodium/taurocholate-cotransporting polypeptide (Ntcp), and multidrug resistance-associated protein (Mrp 1-6) mRNA levels in liver were determined using the branched DNA signal amplification assay.
Transcription (levels) of Heme oxygenase-1 in liver
1) Confidence 0.62 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.25
Heme oxygenase-1 (Ho-1), NAD(P)H quinone oxidoreductase-1 (Nqo1), organic anion-transporting polypeptides (Oatp1a1, 1a4 and 1b2), sodium/taurocholate-cotransporting polypeptide (Ntcp), and multidrug resistance-associated protein (Mrp 1-6) mRNA levels in liver were determined using the branched DNA signal amplification assay.
Transcription (levels) of Ho-1 in liver
2) Confidence 0.56 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.25
The greatest increase in constitutive JNK activity was observed in null liver and was accompanied by a significant increase in activator protein-1 DNA binding activity (8-fold) and in the mRNA levels for the antioxidant protein heme oxygenase-1 compared with wild type.
Transcription (levels) of heme oxygenase-1 in liver
3) Confidence 0.52 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12646564 Disease Relevance 0 Pain Relevance 0.05
Analysis of Gstt2, Hmox1, and Ephx1 mRNA levels revealed that the up-regulation of the antioxidant defense system in the Csbm/m/Xpa?
Transcription (levels) of Hmox1
4) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.16 Pain Relevance 0
Hepatotoxic doses of APAP and CCl4 increased Ho-1 and Nqo1 mRNA levels by 22- and 2.5-fold, respectively, and reduced Oatp1a1, 1a4, and Ntcp mRNA levels in liver.
Transcription (levels) of Ho-1 in liver
5) Confidence 0.48 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15496496 Disease Relevance 0.15 Pain Relevance 0.22
Treatment with APAP for 1h caused a significant increase in the levels of haem oxygenase-1 (HO-1; 2.85-fold) and glutamate cysteine ligase (GCLC; 1.62-fold) mRNA.
Transcription (levels) of HO-1 associated with glutamate and paracetamol
6) Confidence 0.45 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.12 Pain Relevance 0.58
These data are consistent with earlier findings demonstrating increased Hmox1 transcription in RAW264.7 macrophages after luteolin treatment [60].
Transcription (transcription) of Hmox1 in macrophages
7) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.20 Pain Relevance 0.07
Effects of GTN and PETN on HO-1 mRNA expression in cultured EA.hy 926 cells
Transcription (expression) of HO-1
8) Confidence 0.35 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0 Pain Relevance 0.08
Effects of GTN and PETN on HO-1 mRNA expression in cultured EA.hy 926 cells
Transcription (expression) of HO-1
9) Confidence 0.35 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.12 Pain Relevance 0.06
PETN concentration-dependently increased the HO-1 mRNA levels in EA.hy 926 cells resulting in a significant increase at 50 ?
Transcription (levels) of HO-1
10) Confidence 0.35 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.13 Pain Relevance 0.10
M GTN for 12 h. mRNA expression of HO-1 was analyzed with quantitative real-time RT.
Transcription (expression) of HO-1
11) Confidence 0.34 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0 Pain Relevance 0.09
Transcripts of Sulfirexodin 1 (Srxn1), Biliverdin reductase B (Blvrb), Heme oxigenase 1 (Hmox1), and Glutamate-cysteine ligase (Gclm) are components of the cellular anti-oxidant response [41-43] and were all induced by luteolin treatment (Fig. 3A-D).
Transcription (Transcripts) of Hmox1 associated with glutamate
12) Confidence 0.34 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.37 Pain Relevance 0.14
We found that many neutrophils expressing heme oxygenase-1 mRNA and protein were recruited into the damaged spinal cord with extensive hemorrhages during early stage of spinal cord injury.
Transcription (expressing) of heme oxygenase-1 in spinal cord associated with cva and spinal cord
13) Confidence 0.32 Published 2002 Journal J. Neurotrauma Section Abstract Doc Link 11990353 Disease Relevance 0.77 Pain Relevance 0.61
Even more, it was recently reported that hepatitis C (HCV) infection increased HO-1 mRNA expression and protein levels in human liver cells and was suggested to likely represent a protective response against possible oxidative or other insult from HCV proteins [36].
Transcription (expression) of HO-1 in liver associated with hepatitis c virus infection, infection and hepatitis
14) Confidence 0.30 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 1.26 Pain Relevance 0.18
Heme oxygenase-1 (HO-1) protein and mRNA expression
Transcription (expression) of HO-1
15) Confidence 0.29 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.12 Pain Relevance 0.05
One-way ANOVA (with Bonferroni's or Dunn's correction for comparison of multiple means) was used for comparisons of vasodilator potency and efficacy, L-012-derived chemiluminescence, ALDH-2 activity as well as HO-1 mRNA expression.
Transcription (expression) of HO-1 associated with potency
16) Confidence 0.26 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0 Pain Relevance 0.10
As expected, increased mRNA levels from three NRF2 target genes, HO-1, GSTa2, and GCLC were found in CRIF1 knockdown cells when compared with control cells (Fig. 7C).


Transcription (levels) of HO-1
17) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0
Cytokine and heme oxygenase-1 (HO-1) mRNA levels.
Transcription (levels) of oxygenase-1 associated with cytokine
18) Confidence 0.25 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.25 Pain Relevance 0.21
Heme oxygenase-1 (HO-1) protein and mRNA expression
Transcription (expression) of oxygenase-1
19) Confidence 0.25 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.12 Pain Relevance 0.05
Cytokine and heme oxygenase-1 (HO-1) mRNA levels.
Transcription (levels) of HO-1 associated with cytokine
20) Confidence 0.25 Published 2007 Journal Biochemical and Biophysical Research Communications Section Body Doc Link PMC2096715 Disease Relevance 0.25 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox